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Session 25
Oral Abstract Session
Immunology Wednesday, 10 am - 12:30 pm 6C |
| Moderators |
Daniel Douek, NIAID AIDS Vaccine Res. Ctr., NIH, Bethesda, MD and Alexandra
Trkola, Univ. Hosp., Zurich, Switzerland | ||
| 10:00 101. | Impact of Thymectomy on the Peripheral T-Cell Pool in Rhesus Macaques before and after Infection with SIV S. T. Arron1, A. Gettie2, J. Blanchard1, 2, D. Ho1, and L. Zhang*1 1Aaron Diamond AIDS Res. Ctr., Rockefeller Univ., New York, NY and 2Tulane Regional Primate Res. Ctr., Covington, LA
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| 10:15 102. | Kinetic Subpopulations of T Cells in Humans: Effects of HIV-1 Infection M. Hellerstein*, R. Hoh, M. Hanley, D. Cesar, D. Lee, R. Neese, and J. M. McCune Univ. of California, San Francisco; Univ. of California, Berkeley; and Gladstone Inst. of Virology and Immunology, San Francisco, CA
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| 10:30 103. | Prolonged and Preferential Survival of CD4+ T Lymphocytes in HIV-Infected Patients Receiving IL-2 Therapy J. Kovacs*1, R. A. Lempicki2, I. A. Sidorov4, J. W. Adelsberger2, G. Kelly1, J. A. Metcalf3, R. T. Davey3, J. Falloon3, M. A. Polis3, J. Tavel3, R. Stevens2, L. Lambert2, D. Hosack2, H. J. Issaq2, S. Fox2, S. Leitman1, M. W. Baseler2, H. Masur1, D. S. Dimitrov4, and H. C. Lane3 1Clin. Ctr., 3NIAID, and 4NCI, NIH, Bethesda, MD; and 2SAIC, Frederick, MD
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| 10:45 104. | Intermittent IL-2 in HIV-Infected Patients Leads to Peripheral Expansion of a Novel Subset of Naïve CD4+ T Cells I. Sereti*1, V. Natarajan2, J. W. Adelsberger2, J. A. Metcalf1, H. Martinez-Wilson1, K. Anthony1, J. Kovacs3, and H. C. Lane1 1NIAID, NIH, Bethesda, MD; 2 Sci. Applications Intl. Corp., Frederick, MD; and 3Clin. Ctr., NIH, Bethesda, MD
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| 11:00 105. | HIV-1 Core Envelope Glycoproteins Deficient in T-Cell Helper Epitopes C. Grundner*1, J. Kang1, M. Koch1, J. Sodroski1,2, and R. Wyatt3 1Dana-Farber Cancer Inst., Boston, MA; 2Harvard Med. Sch. and Harvard Sch. of Publ. Hlth., Boston, MA; and 3NIAID Vaccine Res. Ctr., NIH, Bethesda, MD
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| 11:15 106. | A Novel Approach to the Analysis of Specificity, Clonality, and Frequency of HIV-Specific T-Cell Responses Reveals a Mechanism for Lack of Escape within an Immunodominant Epitope D. Douek*1, M. Betts1, J. Brenchley1, B. Hill1, D. Ambrozak1, K. L. Ngai2, J. Casazza3, and R. Koup1 1NIAID Vaccine Res. Ctr., NIH, Bethesda, MD; 2MegaBases, Inc., Northwestern Univ., Chicago, IL; and 3Univ. of Texas Southwestern Med. Ctr., Dallas
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| 11:30 107. | Enhancement of HIV-1-Specific CTL Responses in the Peripheral Blood during STI is Largely Due to Redistribution of Pre-Existing Virus-Specific CD8+ T Cells from the Lymph Nodes M. Altfeld*1, J. V. Lunzen2, N. Frahm2, X. Yu1, R. L. Eldridge1, H. J. Stellbrink2, and B. Walker1 1Partners AIDS Res. Ctr., Massachusetts Gen. Hosp. and Harvard Med. Sch., Boston, MA and 2 Univ. Eppendorf, 1st Med. Klinik, Hamburg, Germany
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| 11:45 108. | HIV-Specific Cellular Immunity and Partial Control of Drug-Resistant vs Wild-Type Viremia S. G. Deeks*1, E. Sinclair2, J. M. Harris, H. T. Maecker, B. Bredt2, E. Hagos1, J. Martin1, and J. M. McCune2 1Univ. of California, San Francisco; 2Gladstone Inst. of Virology and Immunology, San Francisco Gen. Hosp., CA; and 3BD BioSci., San Jose, CA
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| 12:00 109. | Constitutive and Induced Expression of DC-SIGN on Dendritic Cell and Macrophage Subpopulations in Situ and in Vitro E. J. Soilleux1, L. S. Morris1, G. Leslie2, J. Chehimi3, Q. Luo3, E. Levroney4, J. Trowsdale1 , L. J. Montaner3, R. W. Doms2, D. Weissman2, N. Coleman1, B. Lee*4, and 5 1Univ. of Cambridge, UK; 2Univ. of Pennsylvania, Philadelphia; 3Wistar Inst., Philadelphia, PA; 4Univ. of California, Los Angeles Sch. of Med.; and 5 Univ. of California, Los Angeles AIDS Inst.
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| 12:15 110. | Cholesterol is Essential for Chemokine Binding to Receptors, CCR5 and CXCR4: Implications for HIV Infection D. H. Nguyen* and D. D. Taub NIH, Baltimore, MD
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