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Cancer Incidence among HIV-Infected Men and Women in Southern Europe D. SERRAINO*, A. BOSCHINI, C. PRADIER, M. DORRUCCI, P. CARRIERI, P. BALLARINI, G. IPPOLITO, and G. REZZA.
IRCCS L, Spallanzani, Rome, Italy. Background: Studies from North America, Australia and Europe have evidenced an excess of several cancer types, in addition to KS and NHL, among HIV-infected individuals. For some cancer sites, however, the results were not consistent. To assess the spectrum of malignancies associated with HIV infection in Southern Europe, longitudinal data from a cohort of HIV seroconventers and from two HIV seroprevalent cohorts in Italy and France were combined and analysed.
Methods: 5,281 HIV-positive men (3,422 IDU, 1,365 homosexuals and 494 heterosexuals) were followed up for 19,609 person-years (PY), and 2,141 HIV-positive women (1,340 IDU and 801 heterosexuals) were followed-up for 9,070 PY. The number of observed cases was compared with the expect one, based on age- and sex-specific incidence rates in the general population of Italy or France. Age-standardised incidence ratios (SIR), and their 95% confidence intervals (CI) were computed.
Results: Among HIV-positive males, significantly increased SIR emerged for liver cancer (SIR=18.6), Hodgkin's disease (HD) (SIR=11.2), and lung cancer (SIR=3.6). When the totality of non-AIDS-defining cancers was considered, a 2-fold higher risk emerged (95% CI: 1.4-2.9). Among women, a particularly elevated risk for invasive cervical cancer (ICC) was evident among IDU (SIR=16.7, 95% CI: 5.2-28.2).
Conclusion: These results confirm previous studies showing an excess of HD and ICC among HIV-positive individuals, and they suggest that liver and lung cancers' risks may also be increased as a consequence of HIV.
Key Words: Cancer, HIV, Risk
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