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Resistance Exercise Training Reduces Hypertriglyceridemia in HIV-Infected Men Treated with Antiviral Therapy K. E. YARASHESKI*, P. TEBAS, B. STANERSON, D. MARIN, S. CLAXTON, M. KENNEDY, W. TANTISIRIWAT, and W. G. POWDERLY.
Washington Univ. Med. Ctr. St. Louis, MO Background: The metabolic complications associated with HAART may respond favorably to exercise training. Using a paired design, we determined if 16wk of individualized, supervised, progressive weight-lifting exercise decreases fasting serum triglycerides, adipose tissue mass, and increases lean mass and muscle strength in 17 HIV-infected men.
Methods: The resistance exercise regimen consisted of 3-upper- and 4-lower-body exercises done for 1-1.5 hr/d, 3 d/wk for 48 sessions. Initially, weights equivalent to 60-65% of each participant's maximum voluntary strength were lifted 10x. Each exercise was done 3-4x/session. By end, the weights had progressively increased to 90-100+% of initial maximum strength, lifted 4-5x and 4x/session. Maximum voluntary muscle strength was determined during wk1 and 16. Fasting serum lipid levels were determined before and at the end of the program. DEXA was used to determine whole-body and regional lean and adipose tissue distributions.
Results: Weight-lifting training increased lean mass in the whole-body 1.25kg (p=0.01; 2-tailed paired t-test), appendicular and trunk regions (0.64 and 0.61 kg; p<0.04). Adipose tissue mass in the whole-body, appendicular and trunk regions was not reduced (p=NS) following training. Muscle strength increased 22-35% (p<0.0001) on all exercises. Fasting serum triglycerides were decreased at the end of training (288 to 209mg/dL; p=0.05). Triglycerides were reduced after exercise in 11/17 subjects. Nine of these 11 were hypertriglyceridemic at baseline. Total-, HDL-, and LDL-cholesterol were unaffected by exercise training.
Conclusions: 4 months of progressive resistance exercise training reduced serum triglyceride levels, increased muscle strength and lean mass in HIV-infected men with baseline hypertriglyceridemia. Adipose tissue mass and distribution were not changed. This implies that exercise training-induced improvements in lean tissue mass may promote triglyceride clearance from the circulation of hypertriglyceridemic HIV-infected men treated with antiviral therapy.
Key Words: body composition, exercise training, hyperlipidemia
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