591   High Incidence of HHV8-Associated Non-Hodgkin Lymphoma in HIV⁺Patients with Multicentric Castleman Disease.

E. Oksenhendler*¹, E. Boulanger¹, N. Dupin², C. Boshoff³, M. T. Daniel¹, P. G. Isaacson³, V. Meignin¹, and J. P. Clauvel¹.
¹Hosp. Saint-Louis, Paris, France; and²Tarnier, Paris, France; and³Univ. Coll. London, UK.

Background/Methods:50 HIV-infected patients with a histological diagnosis of Castleman Disease (CD) were followed in a prospective cohort study. At entry, KS was associated in 34, the median CD4 cell count was 148/ mm³, and 2/24 had undetectable plasma HIV RNA.

Results:With a mean follow-up of 24 months, 11 patients developed NHL. 6/11 had KS. 7/10 had a CD4 cell count >200/mm³4/6 had plasma HIV RNA <2,6 log.

Conclusions:The NHL incidence (11/100 patients/y) in this cohort is tenfold higher than in the general HIV population. Two patients had classic HHV8+/EBV+ Primary Effusion Lymphoma. Four patients had visceral NHL with morphological and phenotypical features of PEL cells. Five patients had plasmablastic HHV8+ NHL suggesting that they originate from the CD lesion.