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K. Chang*, J. Kim, S. Hong, Y. Song, H. Lee, and S. Lim.
Yonsei Univ. Coll. of Med., Seoul, South Korea.
Background:Anecdotal reports of bone disorders and a cross-sectional analysis of bone mineral loss have been reported in human immunodeficiency virus (HIV)-infected Caucasians receiving highly active antiretroviral therapy (HAART). We questioned if a similar adverse effect of bone mineral density exists in HIV-infected Koreans.
Methods:We performed a cross-sectional analysis of lumbar spine (L2—L4) and proximal femur bone mineral density in 109 subjects. HIV-infected HAART-experienced (Group 1, n = 45), HIV-infected HAART-naive (Group 2, n = 32) and healthy adults (Group 3, n = 32) were examined using dual energy X-ray absorptiometry(DEXA). Non-parametric statistical tests were used to compare t - and z -scores for spine and hipbone mineral density between groups.
Results:The most distinctive difference of the adverse effects of HAART in this study with Koreans is that, unlike Caucasians, the incidence of osteoporosis and osteopenia is not increased in the HAART-experienced group compared to the HAART-naive group. Osteopenia or osteoporosis of L-spine observed in Groups 1, 2 and 3 was 21%, 25% and 24%, respectively, and osteopenia or osteoporosis of femoral neck was 18%, 24% and 19%, respectively, which was statistically insignificant. The median t -scores of L-spine and proximal femur in Groups 1, 2 and 3 were -0.20, -0.55 and -0.15, respectively, and the median z -scores of L-spine and proximal femur in Groups 1, 2 and 3 were 0, -0.20 and 0.10, respectively.
Conclusion:Osteoporosis and osteopenia are not adverse effects of HAART in Korean HIV-infected subjects. These observations warrant further race-specific metabolic complication studies in HIV-infected subjects submitted to HAART.
© 8th Conference on Retroviruses and Opportunistic Infections