Abstract

E-mail Abstract Author Add To Itinerary Session Search Abstracts Program

Session 90 Poster Session Incidence, Prevalence, and Pathogenic Correlates of Insulin Resistance and Lipodystrophy Syndrome Session Time: 4:30-6:30 pm Room 4E-F

687-T. Comparison of Regional Body Composition Changes in Lipodystrophy with Those of Tuberculosis-Related Wasting N. Paton*, Y-M. Ng, Y-K. Chua, J. Aboulhab, and F. Karim Tan Tock Seng Hosp., Singapore Background: The pattern of regional body composition changes in HIV-infected patients with lipodystrophy (LD) and with wasting related to opportunistic infections such as tuberculosis (TB) has not been clearly defined. The aim of this study was to compare and contrast the changes in regional body composition accompanying TB and LD. Methods: Whole body DEXA scans were performed in HIV-infected patients with active TB (HIVTB, n = 11) or with LD (HIVLD, n= 12) and clinically stable patients with no LD or opportunistic infections (HIV control, n = 24). Appendicular soft tissue mass was calculated from the sum of arm and leg values. Group means were compared by ANOVA. Results: Appendicular fat mass was lower in HIVTB (3.6 kg) and HIVLD (3.3 kg) than in HIV controls (5.6kg). Appendicular lean mass was lower in HIVTB (15.8 kg) than in HIV controls (18.9 kg), and was similar in HIVLD (19.2 kg). Trunk fat was lower in HIVTB (2.6 kg) than in HIV controls (4.8 kg), and was similar in HIVLD (4.5 kg). Trunk lean tissue was similar in all 3 groups (23.8 kg, 22.3 kg and 23.4 kg, for HIV controls, HIVTB, and HIVLD, respectively). The appendicular fat to total body fat ratio was increased in HIVTB (0.58) and decreased in HIVLD (0.39) compared with the ratio in HIV controls (0.50). The appendicular lean to total body lean ratio was decreased in HIVTB (0.38) and unchanged in HIVLD (0.42) and HIV controls (0.41). All stated differences are statistically significant (p< 0.05). Conclusions: Reduced appendicular fat mass is a feature of both LD and wasting associated with TB. However, other regional soft tissue measurements and appendicular to whole body fat and lean tissue ratios can distinguish the two processes. DEXA is a valuable tool in the investigation and definition of lipodystrophy.

©2002 9th Conference on Retroviruses and Opportunistic Infections