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Session 91 Poster Session Cardiovascular Disease Risk Session Time: 4:30-6:30 pm Room 4E-F

693-T. Circulating Cell Adhesion Molecules Are Elevated in HIV+ Women L. Bausserman*, K. Tashima, M. Dispigno, and D. Maceroni Miriam Hosp., Brown Med. Sch., Providence, RI Background: Elevated soluble cell adhesion molecules (CAMs) have been associated with atherosclerotic risk. We hypothesized that these inflammatory markers would be elevated in HIV+ patients and investigated relationships of intercellular cell adhesion molecule-1 (sICAM), vascular cell adhesion molecule-1 (sVCAM), and E-selectin with measures of body fat distribution, lipids and carbohydrate metabolism in HIV+ women Methods: This cross-sectional study used samples which had been collected over a period of 2 years and stored frozen at -70oC. Abnormally distributed values were log transformed. ANOVA was used for comparisons among ethnic groups and treatment regimens. Pearson correlations were used for all other comparisons. Results: The study population consisted of 84 women (66% Caucasian, 18% African American, 10% Hispanic, and 6% other) 41±7.9 years of age. Concentrations of sICAM (467±210 ng/mL), sVCAM (730±-447 ng/mL) and sE-selectin (67.7±31.9 ng/mL) were elevated compared to published values for women but did not differ by race or treatment regimen (HAART+PI, HAART+NNRTI, NRTI only, no treatment) and were not related to time on treatment or time in storage. None of the CAMs correlated to WHR, BMI, insulin, or glucose concentrations. All 3 CAMs were inversely related to LDL concentration (p<0.05). In addition, sICAM and sVCAM were inversely related with HDL3 (p<0.001 for both) and E-selectin was directly related to HDL2 concentrations (p<0 .01). Conclusions: Concentrations of cell adhesion molecules are elevated in HIV+women and are related to lipoprotein concentrations. Further studies will be required to determine the mechanisms involved but the data suggest that these markers may reflect additional risk of vascular disease in HIV+ patients.

©2002 9th Conference on Retroviruses and Opportunistic Infections