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Ashley Haase
Univ. of Minnesota Med. Sch., Minneapolis
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This presentation will focus on how access, substrate availability, and spatial proximity affect transmission and propagation of SIV and HIV infection in vivo. A description of the first in rhesus macaque SIV model of heterosexual transmission, the role of preexisting inflammation in creating a “leaky” mucosal barrier, the different roles of resting and activated CD4+ T cells in transmission, virus production, and the dynamics of infection, based on evidence derived from new amplification technologies to visualize virus production. The presentation will conclude with a discussion of how virus-specific CD8, CTLs, and other factors profoundly alter levels of virus gene expression in vivo vis-a-vis infection of cell cultures.
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