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Session 42
Poster Session
CD8+ T-Cell Responses and Influences of CD4+ T Cells 4:30-6:30 pm 4E-F |
to view the poster for an abstract.| 217-T. | Replicative Senescence of HIV-Specific CD8+ T Cells Defined by CD57 J. Brenchley*1, D. Ambrozak1, N. Karandikar2, M. Betts1, J. Kuruppu1, D. Douek1, and R. Koup1 1NIAID, NIH, Bethesda, MD and 2Univ. of Texas Southwestern Med. Ctr., Dallas
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| 218-T. | Frequency of HIV-Specific CD8+ T Cells Is not a Predictor of the Breadth of the HIV-Specific CD8+ T-Cell Response M. Betts*, D. Ambrozak, J. Brenchley, D. Douek, and R. Koup NIAID Vaccine Res. Ctr., NIH, Bethesda, MD
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| 219-T. | HIV-1-Specific CD8+ T Lymphocytes in HIV-1 Infected Longterm-Non-progressors (LTNP) and Patients with Absent or Strong Lymphoproliferative (LP) Responses to HIVp24 Have Comparable Phenotypes Suggestive of Memory and not Effector Cytotoxic T-Lymphocytes (CTL) C. Lange*1,4, B. Harnisch2, Z. Xu2, P. Shankar2, S. Lee3, H. Valdez1, R. Asaad1, M. Lederman1,, and J. Lieberman2 1Univ. Hosp., Cleveland, OH; 2Ctr. for Blood Res., Boston, MA; 3Dana Farber Cancer Inst., Harvard Med. Sch., Boston, MA; and 4Med. Clin., Res. Ctr., Borstel, Germany
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| 220-T. | HIV-1-Specific CD8+ T Cells Recognize Novel Class I MHC-Restricted Epitopes during Primary HIV-1 Infection J. Cao*1,2, J. McNevin1, L. Fink1, S. Holte1, L. Corey1,2, and M. J. McElrath1 1Fred Hutchinson Cancer Res. Ctr., Seattle, WA and 2Univ. of Washington, Seattle
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| 221-T. | Granule Dependent -- but not Granule-Independent -- Mechanisms of Lysis Are Defective in CD8+ T Cells of HIV-Infected, Antiviral Therapy-Treated Individuals D. Trabattoni*1, S. Piconi1, A. Migliorino2, E. Seminari3, G. Rizzardini2, M. Biasin1, R. Maserati3, and M. Clerici1 1Univ. Milano; 2Busto Arsizio Hosp., Varese; and 3IRCCS Policlinico S. Matteo, Pavia, Italy
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| 222-T. | Phenotype and Function of Anti-HIV Gag and Pol Specific CD8+ Cytotoxic Lymphocytes in a Cohort of Untreated Chronically HIV-Infected Patients J. Benito*, M. López, S. Lozano, J. Gonzalez-Lahoz, and V. Soriano Inst. de Salud Carlos III, Madrid, Spain
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| 223-T. | A Systematic Comparison of Methods to Measure HIV-1-Specific CD8 T Cells A. Samri*, E. Iglesias, G. Kamkamidze, Y. Sun, G. Carcelain, T. Decoville, P. Debre, and B. Autran HOsp. Pitié-Salpêtrière, Paris, France
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| 224-T. | IL-15 Inhibits CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells from HIV-Infected Individuals Y. Mueller*1, P. Bojczuk1, J. Witek1, J. Altman2, and P. Katsikis1 1MCP Hahnemann Univ., Philadelphia, PA and 2Emory Univ., Atlanta, GA
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| 225-T. | IL-15 Enhances Effector Function of Memory CD8+ T Cells from HIV-Infected Individuals Y. Mueller*1, P. Bojczuk1, J. Witek1, J. Altman2, and P. Katsikis1 1MCP Hahnemann Univ., Philadelphia, PA and 2Emory Univ., Atlanta, GA
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| 226-T. | Perforin Expression and IFN- Y. Sun1, C. Blanc1, A. Schnuriger1, A. Faussart1, A. Samri*1, G. Carcelain1, Y. Yasuko2, P. Debré1, and B. Autran1 for the ALT Immunoco Study Groups 1Hosp. Pitié-Salpétrière, Paris, France and 2NIAID, Tokyo, Japan
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| 227-T. | The Maturation Phenotype of HIV-Specific CD8+ T Cells Is Associated with Decreased Plasma Viral Load P. Goepfert*1, B. Edwards1, M. Bachinsky2, U. SadasivanNair2, and L. Tussey2 1Univ. of Alabama, Birmingham and 2Merck Res. Labs., West Point, PA
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| 228-T. | Comprehensive Characterization of HIV-1-Specific CTL Responses Directed against the Entire Expressed HIV-1 Genome Using a Rapid Peptide-Matrix-System M. M. Addo*1, X. G. Yu1, D. Cohen2, R. L. Eldridge1, D. Strick1, M. N. Johnston1, J. T. Blackard2, C. Brander1, S. Boswell2, P. Goulder1, E. Rosenberg1, M. Altfeld1, and B. D. Walker1 1Partners AIDS Res. Ctr., Massachusetts Gen. Hosp., Boston and 2Fenway Community Hlth. Ctr., Boston, MA
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| 229-T. | Effector CD8 T Cells in HIV-Infected Children V. Haridas*, T. W. McCloskey, R. Pahwa, V. Chitnis, and S. Pahwa North Shore-Long Island Jewish Res. Inst., Manhasset, NY
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| 230-T. | IL-15 Augments HIV Specific CD8 T-Cell Responses in Children Chronically Infected with HIV; Implications for Adjuvant Therapy V. Haridas*, V. Chitnis, S. Kapadia, and S. Pahwa North Shore-Long Island Jewish Res. Inst., North Shore Univ. Hosp., New York Univ. Sch. of Med., Manhasset
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| 231-T. | Viral CTL Escape Mutations do Not Explain HIV Progression in HLA B*5701+ Patients S. Migueles*, A. Laborico, H. Imamichi, and M. Connors NIAID, NIH, Bethesda, MD
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| 232-T. | CTL Response to Lab-Adapted HIVIIIB Virus Is not Predictive of Autologous Virus Recognition S. K. Lee*, Z. Xu, J. Lieberman, and P. Shankar Harvard Med. Sch., Boston, MA
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| 233-T. | Improvement, but not Normalization, of TCRBV Repertoire after 36 Months of HAART A. Giovannetti, F. Mazzetta, M. Marziali, M. Pierdominici, I. Mezzaroma, and F. Aiuti* Univ. La Sapienza, Rome, Italy
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| 234-T. | Distribution and Functional Analysis of Memory CD8 and CD4 T Lymphocytes in Different Anatomic Compartments K. Ellefsen*1, A. Harari1, P. Champagne1, 2, R. P. Sekaly2, and G. Pantaleo1 1CHUV, Lausanne, Switzerland and 2Univ. de Montréal and McGill Univ., QC, Canada
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| 235-T. | HIV Immunity in Children with Established HIV Infection A. Weinberg*, G. Pott, and J. Patterson Univ. of Colorado Hlth. Sci. Ctr., Denver
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| 236-T. | Quantitation of CD4 and CD8 T-Cell Proliferation to Soluble Antigens and Inactivated HIV-1 by Flow Cytometry in Various Stages of Disease. M. da Silva*1, J. Coderre1, J. Sullivan1, J. Lifson2, and T. Greenough1 1Univ. of Massachusetts Med. Sch., Worcester and 2SAIC and NCI, NIH, Frederick, MD
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| 237-T. | CD4 and CD8 Lymphocyte Proliferation Defects Are Tightly Correlated in HIV-Infected Patients and Are Related to Prior Episodes of Circulating CD4 Lymphopenia S. Sieg*, J. Mitchem, D. Bazdar, and M. Lederman Case Western Reserve Univ., Univ. Hosp., Cleveland, OH
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| 238-T. | Persistence of CD8+ HIV-Specific Response Is Associated with Preservation of the HIV-Specific CD4+ Response. G. Alter1, C. M. Tsoukas1, R. LeBlanc1, E. Lefebvre2, H. Dion2, R.-P. Sékaly3, J.-P. Routy1, and N. F. Bernard*1 1McGill Univ. Hlth. Ctr.; 2Clinique l’Actuel; and 3Univ. of Montreal, QC, Canada
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| 239-T. | T-Cell Immunity Induced by HIV-1 and HIV-2 Infection in Senegal S. Sow1, N. Kiviat2, L. Musey2, S. Hawes2, A. Wilson*3, C. W. Critchlow2, H. Diallo-Agne1, N. Agoff2, and M. J. McElrath2 1Univ. of Dakar, Senegal; 2Univ. of Washington, Seattle; and 3Fred Hutchinson Cancer Res. Ctr., Seattle, WA
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