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Session 6
Oral Abstract Session
Immunopathogenesis of HIV and SIV Infections Monday, 10 am - 12:30 pm 606-609 |
| Moderators | Giuseppe Pantaleo, CHUV, Lausanne,
Switzerland and Richard Koup, NIAID Vaccine Res. Ctr., NIH, Bethesda, MD | ||
| 10:00 21. | Equal Plasma Viral Loads Predict a Similar Rate of CD4+ T-Cell Decline in Human Immunodeficiency Virus (HIV) Type-1 and HIV Type-2-Infected Individuals from Senegal, West Africa G. S. Gottlieb*1, P. Sow2, S. Hawes1, I. Ndoye3, M. Redman1, A. M. Coll-Seck2, M. Faye2, A. Diop2, J. M. Kuypers1, C. W. Critchlow1, R. Respess4, J. Mullins1, and N. Kiviat1 1Univ. of Washington, Seattle; 2Univ. of Dakar, Senegal; 3 Inst. of Publ. Hlth., Senegal; and 4Roche Molecular Diagnostics, Alameda, CA
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| 10:15 22. | Dynamics of T-Lymphocyte Turnover in Sooty Mangabeys, a Nonpathogenic Host of Simian Immunodeficiency Virus Infection A. Kaur*1, A. F. Barabasz1, M. Rosenzweig1, H. McClure2, M. B. Feinberg2, and R. P. Johnson1 1New England Regional Primate Res. Ctr., Harvard Med. Sch., Southborough, MA and 2Yerkes Regional Primate Res. Ctr., Emory Univ., Atlanta, GA
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| 10:30 23. | Down-Regulation of CCR5 on CD4+ T Cells of SIVsm-Infected Sooty Mangabeys R. Veazey*1, B. Ling2, A. Lackner1, and P. Marx1 1Tulane Regional Primate Res. Ctr., Covington, LA and 2Aaron Diamond AIDS Res. Ctr., Rockefeller Univ., New York, NY
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| 10:45 24. | Blockade of T-Cell Co-Stimulation during Acute SIV Infection in Rhesus Macaques Blunts SIV-Specific Cellular Immune Responses but Does not Protect Them from AIDS D. Garber*, G. Silvestri, A. Fedanov, N. Kozyr, A. Barry, C. Ibegbu, A. Carter, D. Anderson, X. Wang, R. Mittler, H. McClure, C. Larsen, J. Altman, S. Staprans, and M. B. Feinberg Emory Vaccine Res. Ctr., Atlanta, GA
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| 11:00 25. | Innate Immune Defense Mechanisms Involved in the Control of HIV Replication: Inverse Correlation of HIV Viremia with NK Cell Function S. Kottilil*, T. W. Chun, S. Moir, S. Liu, M. McLaughlin, F. Maldarelli, and A. S. Fauci NIAID, NIH, Bethesda, MD
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| 11:15 26. | CD63: A Potential Co-Factor for HIV Infection of Macrophages J. Von Lindern1, K. Grovit-Ferbas, C. Yeramian2, T. C. Pappas1, C. Deng1, G. Herbein1, M. Ferguson1, and W. A. O'Brien*1 1Univ. of Texas Med. Branch, Galveston and 2Univ. of California, Los Angeles
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| 11:30 27. | Intestinal Mucosal Macrophages Are a Principle Reservoir of HIV Replication and Sustain High Levels of Infectious Virus in Persons with Chronic Progressive HIV Infection S. Brodie*, S. Tabet, J. Krieger, R. Haggitt, D. Nickle, A. Johnson, R. W. Coombs, J. Mullins, L. Corey, and C. Celum Univ. of Washington, Seattle
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| 11:45 28. | Expression of DC-SIGN by Intestinal and Genital Mucosal Dendritic Cells in Humans and Rhesus Macaques B. Jameson1, F. Baribaud2, S. Pöhlmann2, D. Ghavimi2, F. Mortari3, R. Doms2, and A. Iwasaki*1 1Yale Univ., New Haven, CT; 2Univ. of Pennsylvania, Philadelphia; and 3R&D Systems, Minneapolis, MN
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| 12:00 29. | Apoptosis of Uninfected Bystander T Cells Induced by HIV-1 Viruses with Enhanced Affinity for CD4 and Increased Exposure of the Co-Receptor Binding Site G. Holm*, C. Zhang, and D. Gabuzda Dana-Farber Cancer Inst., Boston, MA
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| 12:15 30. | The CCR5 Promoter Polymorphism P1 is Associated with Enhanced Expression of HIV-1 Entry Co-Receptors CCR5, CXCR4, and CCR3 on Primary T Cells M. Carrington1, S. Perfetto2, L. Lamoreaux3, C. Wang2, K. Larrimore2, P. Ehrenberg2, and N. Michael*3 1NCI, NIH, Frederick, MD; 2Henry M. Jackson Fndn., Rockville, MD; and 3Walter Reed Army Inst. of Res., Rockville, MD
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