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Program

Session 51   Poster Session
Impact of Host Genetics on Viral Transmission and Disease Progression
4:30-6:30 pm
4E-F

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319-W.
Association of HLA-B22 with Increased Plasma HIV-1 RNA Concentration and Accelerated Progression to AIDS in Caucasian Cohorts
M. T. Dorak*1, J. Tang1, S. Tang1, R. Coutinho2, J. J. Goedert3, R. Detels4, and R. A. Kaslow1
1Univ. of Alabama, Birmingham; 2Amsterdam Cohort Study, The Netherlands; 3NCI, NIH, Bethesda, MD; and 4MultiCtr. AIDS Cohort Study
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320-W.
Homozygosity for HLA-Bw4 Is Not Associated with Protection of HIV-1-Infected Persons of African Ancestry
R. A. Kaslow*1, J. Tang1, M.T. Dorak1, S. Tang1, R. Musonda2, E. Karita3, C. Wilson1,4, S. Allen1, and 3
1Univ. of Alabama, Birmingham; 2Zambia-UAB Project; 3Rwanda Project; and 4REACH Project
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321-W.
The Association of Polymorphisms in HLA Class I and TAP Genes with Resistance to HIV-1 Infection
C. Liu1, M. Carrington2, R. A. Kaslow3, C. Rinaldo4, L. Jacobson5, J. Margolick5, J. Phair6, and R. Detels*1
1Univ. of California, Los Angeles; 2NCI, NIH, Frederick, MD; 3Univ. of Alabama, Birmingham; 4Univ. of Pittsburgh, PA; 5Johns Hopkins Univ., Baltimore, MD; and 6Howard Brown Hlth. Ctr., Northwestern Univ. Med. Sch., Chicago, IL
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322-W.
Polymorphisms of Host Genes in Exposed Seronegative Individuals: Impact on HIV-1 Transmission
Y. Hwangbo, J. McElrath, H. Liu, J. Lee, H. Zhu, L. Corey, and T. Zhu*
Univ. of Washington Sch. of Med., Seattle
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323-W.
HIV-Specific CD8+ T-Cell Responses from HLA-B*57-Positive Adolescents Preferentially Target the Gag Protein
A. Bansal, S. Sabbaj, B. Edwards, C. Perkins, G. D. Ritter, J. Tang, R. A. Kaslow, C. Wilson, M. Mulligan, and P. Goepfert* for the REACH Cohort
Univ. of Alabama, Birmingham
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324-W.
Protective Effect of IL4 -589T Polymorphism on HIV-1 Disease Progression: Relationship with Viral Load
E. E. Nakayama*1, L. Meyer2, A. Iwamoto3, A. Persoz2, Y. Nagai4, C. Rouzioux5, J-F. Delfraissy2, for the SEROCO Study Group, P. Debre6, D. McIlroy6, I. Theodorou6, and T. Shioda1
1Res. Inst. for Microbial Diseases, Osaka Univ., Japan; 2Hosp. Bicêtre, Kremlin-Bicêtre, France; 3Inst. of Med. Sci., Univ. of Tokyo, Japan; 4Natl. Inst. of Infectious Diseases, Tokyo, Japan; 5Hosp. Necker, Paris, France; and 6Hosp. Pitie-Salpetriere, Paris, France
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325-W.
Host Genetic Profiles Strongly Correlate with Virologic and Immunologic Outcomes in HIV-1 Seroprevalent and Primarily African American Adolescents
J. Tang*, C. M. Wilson, S. Meleth, M. Shaen, A. Myracle, E. Lobashevsky, M. Mulligan, and R. A. Kaslow for the REACH Cohort Study Group
Univ. of Alabama, Birmingham
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326-W.
A Novel Genetic Variant of CD28 Gene Is Associated with Susceptibility to HIV Infection
A. Soriano1, C. Martinez1, F. García1, M. Plana*1, E. Palou1, J. Aróstegui1, M. Leujeune1, J. Joseph1, J. Miró1, J. del Romero2, C. Rodriguez2, A. Barrasa2, J. I. Lorenzo3, F. Lozano1, J. M. Gatell1, and T. Gallart1
1Hosp. Clínic-IDIBAPS, Univ. of Barcelona; 2Ctr. Med., Sandoval, Madrid; and 3Hosp. La Fe, Valencia, Spain
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327-W.
Human Major Histocompatibility Complex (HLA) Class I Variants in HIV-1-Infected Zambians and Their Relative Effect on Plasma Viral RNA Concentration in the Absence of Antiretroviral Therapy
J. Tang*1, S. Tang1, U. Fideli1, R. Musonda2, E. Lobashevsky1, S. Allen1, G. Aldrovandi1, and R. A. Kaslow1
1Univ. of Alabama, Birmingham and 2Tropical Disease Res. Ctr., Ndola, Zambia
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