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Session 58
Poster Session
Entry Inhibitors 4:30-6:30 pm 4E-F |
to view the poster for an abstract.| 391-T. | AMD-3100 CXCR4 Receptor Blocker Fails to Reduce HIV Viral Load by > 1 Log following 10-Day Continuous Infusion C. Hendrix*1, A. C. Collier2, M. Lederman3, R. Pollard4, S. Brown5, M. Glesby6, C. Flexner1, G. Bridger7, K. Badel7, R. MacFarland7, G. Henson7, and G. Calandra7 for the AMD-3100 HIV Study Group 1Johns Hopkins Univ., Baltimore, MD; 2Univ. of Washington, Seattle; 3Case Western Reserve Univ., Cleveland, OH; 4Univ. of Texas Med. Branch, Galveston; 5AIDS Res. Alliance, West Hollywood, CA; 6Cornell Univ., New York, NY; and 7AnorMED, Langley, BC, Canada
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| 392-T. | Analysis of Patient-Derived HIV-1 Isolates Suggests a Novel Mechanism for Decreased Sensitivity to Inhibition by T-20 and T-649 M. Heil*1, J. Decker1,2, J. Sfakianos1, G. Shaw1,2, E. Hunter1, and C. Derdeyn1 1Univ. of Alabama and 2Howard Hughes Med. Inst., Birmingham, AL
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| 393-T. | T-20 and DAPD have Synergistic in Vitro Anti-HIV Interactions C. Tremblay*1, D. Poulain1, J. L. Hicks1, F. Giguel1, C. Kollmann1, T. C. Chou2, and M. S. Hirsch1 1Massachusetts Gen. Hosp., Boston and 2Memorial Sloan-Kettering Cancer Ctr., New York, NY
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| 394-T. | Identification of HIV-1 Fusion Inhibitors Derived from Synthetic Combinatorial Peptide Libraries C. Boggiano* and S. E. Blondelle Torrey Pines Inst. for Molecular Studies, San Diego, CA
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| 395-T. | In Vivo Evolution of X4 HIV-1 Variants in the Natural Course of Infection Coincides with Reduced Sensitivity to CXCR4 Antagonists R. P. van Rij1, J. A. Visser1, M. Naarding1, D. Schols2 , and H. Schuitemaker*1 1CLB-Sanquin and Landsteiner Lab., Academic Med. Ctr., Univ. of Amsterdam, The Netherlands; and 2Rega Inst., Leuven, Belgium
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| 396-T. | HIV-1 Mutants Less Susceptible to SCH-D, a Novel Small-Molecule Antagonist of CCR5 Z. Chen*1, B. Hu1, W. Huang2, T. He1, Y. Huang1, J. Strizki3, S. Xu3, L. Wojcik3, J. M. Whitcomb2, L. Zhang1, C. J. Petropoulos2, B. Baroudy3, and D. Ho1 1Aaron Diamond AIDS Res. Ctr., Rockefeller Univ., New York, NY; 2ViroLogic, Inc., South San Francisco, CA; and 3Schering-Plough Res. Inst., Kenilworth, NJ
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| 397-T. | Genotypic and Phenotypic Analysis of in Vitro Generated HIV-1 Escape Isolates to the CCR5 Antagonist SCH-C J. Riley*, L. Wojcik, S. Xu, and J. Strizki Schering-Plough Res. Inst., Kenilworth, NJ
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| 398-T. | Antagonism of the CCR5 Receptor by SCH-C Leads to Elevated S. Xu*, L. Wojcik, and J. Strizki Schering-Plough Res. Inst., Kenilworth, NJ
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| 399-T. | Role of Co-Receptor Inhibitors in Blocking HIV-1 Primary Isolates in Vitro P. Citterio*1, E. Bulgheroni1, F. Croce1, M. Lo Cicero1, P. Bagnarelli2, M. Galli1, and S. Rusconi1 1Univ. of Milan and 2Univ. of Ancona, Italy
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| 400-T. | Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5 K. Maeda*1, K. Yoshimura1, S. Shibayama2, H. Habashita2, T. Miyakawa1, M. Aoki1, Y. Koh1, H. Nakata1, H. Tada2, K. Sagawa2 , D. Fukushima2, and H. Mitsuya1 1Kumamoto Univ., Japan; 2Ono Pharmaceutical Co. LTD, Osaka, Japan; and 3NCI, NIH, Bethesda, MD
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| 401-T. | PRO 542 (CD4-IgG2) has a Profound Impact on HIV-1 Replication in the Hu-PBL-SCID Mouse Model M. Franti*1, T. O’Neill2, P. Maddon2, D. R. Burton1, P. Poignard1, and W. Olson2 1Scripps Res. Inst., La Jolla, CA and 2Progenics Pharmaceuticals, Inc., Tarrytown, NY
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| 402-T. | Identification of CCR5 Co-Receptor Inhibitors that Potently and Selectively Block HIV-1 Replication W. Olson*1, T. Dragic2, B. O’Hara1, K. Nagashima1, F. Tsamis2, M. Westby3, and N. Cammack3 1Progenics Pharmaceuticals, Inc., Tarrytown, NY; 2Albert Einstein Coll. of Med., Bronx, NY; and 3Roche Discovery, Palo Alto, CA
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| 403-T. | The CCR5 Co-Receptor Inhibitor PRO 140 Effectively Controls Established HIV-1 Infection in Vivo M. Franti1, K. Nagashima2, P. Maddon1, D. R. Burton2, W. Olson2, and P. Poignard*1 1Scripps Res. Inst., La Jolla, CA and 2Progenics Pharmaceuticals, Inc., Tarrytown, NY
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