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Session 17
Oral Abstract Presentations HIV/SIV Vaccine Studies Wednesday 10 am - 12:30 pm Ballroom B |
| Moderators: | Glenda Gray Chris Hani Baragwanath Hosp, Univ of Witwaterstrand, Soweto, South Africa and Norman Letvin Beth Israel Deaconess Med Ctr, Harvard Med Sch, Boston, MA |
| 10:00 76 | High Frequency of Stereotypic Viral Escape from Dominant SIV Epitope-specific CTL in DNA-vaccinated Rhesus Monkeys D. H. Barouch*1, J. Kunstman2, J. Glowczwskie2, K. Kunstman2, M. Egan1, S. Santra1, F. Peyerl1, M. Kuroda1, J. Schmitz1, S. M. Wolinsky2, N. L. Letvin1 1Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA and 2Northwestern Univ, Chicago, IL |
| 10:15 77 | Protection Against Pathogenic SIVmac251 Infection Elicited by Vaccination of Rhesus Macaques with a Replication Competent Ad-recombinant Priming/Subunit Boosting Regimen L. J. Patterson1, N. Malkevitch1, J. Pinczewski1, Y. Lou1, B. Peng1, V. S. Kalyanaraman2, P. D. Markham2, R. Pal2, G. N. Pavlakis3, F. A. Robey4, M. Robert-Guroff*1 1Natl Inst of Hlth, NCI, Bethesda, MD; 2Advanced BioSci Labs, Inc, Kensington, MD; 3Natl Inst of Hlth, NCI-Frederick, MD; and 4Natl Inst of Hlth, NIDCR, Bethesda, MD |
| 10:30 78 | Virus-specific Immune Responses in Macaques Inoculated with Single-cycle SIV D. Evans*1, J. Bricker1, J. Lifson2, S. Lang1, R. Desrosiers1 1New England Regional Primate Res Ctr, Southborough, MA and 2Sci Applications Intl Corp Frederick, Natl Cancer Inst at Frederick, MD |
| 10:45 79 | Protective Immunity in Rhesus Monkeys Immunized with Replication-defective HIV-1 Vaccine F. Tung*1, K. Cole2, L. Tung1, H. McClure3, R. Montelaro2 1GeneCure Biotechnologies, Atlanta, GA; 2Univ of Pittsburgh, PA; and 3Emory Univ, Atlanta, GA |
| 11:00 80 | Enhanced Simian Immunodeficiency Virus Replication and Accelerated Progression to AIDS in Macaques Primed to Mount a CD4 But Not a CD8 T-cell Response to the Viral Envelope Protein S. I. Staprans*1, A. P. Barry2, G. Silvestri1, J. T. Safrit2, N. Kozyr2, H. McClure2, D. Montefiori3, J. L. Cohen4, M. B. Feinberg1 1Emory Univ Sch of Med, Atlanta, GA; 2Yerkes Natl Primate Res Ctr, Atlanta, GA; 3Duke Univ Med Ctr, Durham, NC; and 4Natl Inst of Allergy and Infectious Diseases, Bethesda, MD |
| 11:15 81 | Toll-like Receptor Ligands can Modulate Dendritic Cell Functions to Augment Virus-specific T-cell Responses K. Loré*, R. A. Seder, S. Khojasteh, M. R. Betts, J. M. Brenchley, J. C. Kuruppu, S. P. Perfetto, M. Roederer, R. A. Koup Vaccine Res Ctr, Natl Inst of Hlth, Bethesda, MD |
| 11:30 82 | Safety, Tolerability, and CD8+ T-cell Immunogenicity of High Dose Live Recombinant Canarypox ALVAC-HIV Vaccine (vCP1452) in Healthy, HIV-1 Uninfected Adults P. Goepfert*1, H. Horton2, J. McElrath2, S. Surunathan3, L. Mallet3, F. Verdier3, K. Weinhold4, M. Allen5, T. Shea2, Y.-L. Chiu2, T. Rossini2, S. Self2, L. Corey2 1Univ of Alabama at Birmingham; 2Fred Hutchinson Cancer Res Ctr, Seattle, WA; 3Aventis Pasteur, Swiftwater, PA; 4Duke Univ Med Ctr, Durham, NC; and 5Div of AIDS, NIH, Bethesda, MD |
| 11:45 83 | Evolutionary Indicators of Vaccine Efficacy from the ALVAC Phase II Trials D. C. Nickle*1, K. Davis1, Y. Liu1, S. McLaughlin1, I. Genowati1, H. Zhao1, M. Pathmajeyan1, L. Rose1, G. H. Learn1, H. B. Sheppard2, C. Celum1, J. I. Mullins1 1Univ of Washington, Seattle and 2California Dept of Hlth Svcs, Richmond |
| 12:00 84 | What Constitutes Effectiveness for an HIV Vaccine that Ameliorates Viremia: Issues Involving Surrogate Endpoints in Efficacy Trials P. Gilbert*1, V. DeGruttola2, M. Hudgens1, S. Self1, S. Hammer3, L. Corey4 1Fred Hutchinson Cancer Res Ctr, Seattle, WA; 2Harvard Sch of Public Hlth, Boston, MA; 3Columbia Univ Coll of Physicians and Surgeons, New York, NY; and 4Univ of Washington, Seattle |
| 12:15 85lb | Replication-Defective Adenovirus Vector Vaccines Attenuate SIVmac239 and SHIV89.6P Challenge Infections: Effects of Challenge Virus, MHC Class I Expression and Multiple Vaccine Antigen Expression J.W. Shiver*1, D.R. Casimiro1, X. Liang1, W.A. Schleif1, F. Wang1, Z. Zhang1, A. Bett1, M. Davies1, L.G. Tussey1, J.H. Condra1, T. Fu1, L. Handt1, A.B. McDermott2, D.I. Watkins2, E.A. Emini1 1West Point, PA USA and 2Madison, WI USA |