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Session 40
Poster Presentations Virus Entry, Tropism, and Attachment Thursday 1:30 - 3:30 pm Hall D |
| 270 | Syndecans on the Vascular Endothelium Serve as a Major in trans Viral Reservoir for HIV M. Bobardt, A. Saphire, P. Gallay* Scripps Res Inst, La Jolla, CA |
| 271 | Use of CCR5/CXCR4 Chimeric Receptors Reveal Evolution of HIV-1 R5 Phenotype in Relation to Pathogenesis E. M. Fenyö*1, I. Karlsson1, L. Antonsson1, Y. Shi2, A. Karlsson3, J. Albert2, B. Olde1, C. Owman1 1Lund Univ, Lund, Sweden; 2Karolinska Inst, Stockholm, Sweden; and 3South Hosp, Stockholm, Sweden |
| 272 | Evolution of R5 and X4 Human Immunodeficiency Virus Type 1 Gag Sequences in Vivo: Evidence for Recombination Hanneke Schuitemaker*, Janny Visser, Ronald van Rij Sanquin Res and Academic Med Ctr, Amsterdam, The Netherlands |
| 273 | A Subset of HIV and SIVs that Use an Alternative Coreceptor to Infect Primary Human Cell Cultures S Willey1,2, J Reeves2,3, A McKnight2, J Bell4, R Hudson5, K Luzuriaga5, P Clapham*1 1Univ of Massachusetts Med Sch, Worcester; 2Univ of California-London, UK; 3Univ of Pennsylvania, Philadelphia; 4Univ of Edinburgh, Scotland; and 5Univ of Massachusetts Med Sch, Worcester |
| 274 | Role of N-linked Glycosylation of CXCR4 in SDF-1 Binding and HIV-1 Infection J. Wang*1, G. J. Babcock1, H. Choe2, M. Farzan3, J. Sodroski1, D. Gabuzda1 1Dana-Farber Cancer Inst, Boston, MA; 2Children's Hosp, Boston, MA; and 3Partners AIDS Res Ctr, Cambridge, MA |
| 275 | Generation of HIV-1 Co-receptor Switch Variants In Vitro Cristina Pastore*, Alejandra Ramos, Donald E. Mosier Scripps Res Inst, La Jolla, CA |
| 276 | Isolation of a CD4-independent HIV-1 Variant with Novel Phenotypes Including Ability to Infect a Wide Range of CD4- Cells Bouchra Zerhouni*, Amy Traven, Kunal Saha Children's Hosp, Columbus, OH |
| 277 | An Unusual Block in X4-Tropic HIV-1 Challenge of Mouse T-cells J. Baumann*1, G. Ahn1, D. Unutmaz2, V. KewalRamani1 1Natl Cancer Inst at Frederick, MD and 2Vanderbilt Univ, Sch of Med, Nashville, TN |
| 278 | Single-cell Analysis of HIV-1 Infected Primary Human Macrophages A. Brown*, T. Kawano, C. Cheng-Mayer Aaron Diamond AIDS Res Ctr, New York, NY |
| 279 | R5 but Not X4 Primary Viral Isolates of HIV-1 Can Localize Their cDNA to the Nucleus in Monocyte Derived Macrophages J. W. Choi*, I. A. Teo, S. Shaunak Imperial Coll, London, UK |
| 280 | Influence of V3 Charge in Conjunction with gp120 N-linked Glycosylation Patterns on Chemokine and Neutralizing Antibody Inhibition of HIV-1 A Nabatov, G Pollakis, T Linnemann, A Kliphuis, M Chalaby, W Paxton* Univ of Amsterdam, The Netherlands |
| 281 | A Quantitative Assay to Measure Cell-to-Cell Fusion Mediated by HIV-1 Env Glycoprotein Y. Ataman-Önal*1, P-Y. Durand1, F. Reynard1, F. Bedin1, R. Altmeyer2, M. Girard3, B. Verrier1 1UMR2142 CNRS-bioMerieux, Lyon, France; 2Inst Pasteur, Paris, France; and 3Fndn Merieux, Lyon, France |
| 282 | Removal of Glycosylation Sites within Env Proximal to the Rim of the CD4 Binding Pocket Changes Env Affinity for Soluble CD4 C. Pikora*, C. Wittish, R. C. Desrosiers New England Regional Primate Res Ctr, Southborough, MA |
| 283 | Are Broadly Neutralizing Epitopes Exposed Differently on the HIV-1 Envelope Glycoproteins at Different Stages of Infection? L Dacheux*1, Y Ataman2, B Verrier2, F Barin1 1Univ François Rabelais, Tours, France and 2Ecole Normale Supérieure, Lyon, France |
| 284 | HIV-1 Fusion Inhibitors Bind to the N-Helical Coiled-coil Domain in Receptor-activated gp41 N. Kilgore, K. Salzwedel, M. Reddick, G.Allaway, C. Wild* Panacos Pharm, Gaithersburg, MD |
| 286 | Effect of PRA1 Suppression on SIV Virion Release, Infectivity, and Envelope Content P Blancou*, DT Evans, RC Desrosiers Harvard Univ, Southborough, MA |
| 287 | PI3-Kinase Regulates HIV-1 Replication Following Viral Entry in Primary CD4+ T-lymphocytes Fleur Francois, Mary E. Klotman* Mt Sinai Sch of Med, New York, NY |
| 288 | Signaling Response to Cyclophilin A and Stimulation of HIV-1 Infection are Independent Functions of CD147 M. Bukrinsky1, T. Pushkarsky1, V. Yurchenko2, B. Sherry3, B. Brichacek*1 1George Washington Univ Med Ctr, Washington, DC; 2Albert Einstein Coll of Med, Bronx, NY; and 3North Shore Long Island Jewish Res Inst, Manhasset, NY |
| 289 | HIV-1 Enters Primary Human Fetal Brain Microvascular Endothelial Cells by a Lipid Raft-independent Mechanism E. G. Argyris*, E. Acheampong, M. Mukhtar, K. J. Williams, R. J. Pomerantz Thomas Jefferson Univ, Philadelphia, PA |
| 290 | Sigma-2 Receptor Agonists Inhibit HIV Infection of Lymphocytes by Reducing Membrane Sphingomyelin Content KW Crawford*1,2, Z Liao3, JE Hildreth3, WD Bowen2 1Howard Univ Sch of Pharmacy, Washington, DC; 2Natl Inst of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD; and 3Johns Hopkins Univ Sch of Med, Baltimore, MD |
| 291 | Massive Transfer of HIV Particles to Non-permissive Cells during Cell-to-Cell Contacts J Blanco*, J Barretina, B Clotet, J A Esté Fundació IrsiCaixa, Hosp Univ Germans Trias i Pujol, Barcelona, Spain |
| 292 | HIV-1 Mediated Signal Transduction through CCR5 Allows Infection of Resting Memory T-cells A. Matthews*, J. Vasudevan, D. Camerini Univ of Virginia, Charlottesville |
| 293 | Physical Determinants of HIV Infectivity In Vitro: Brownian Motion Underlies Target Cell Limitation M. C. Strain*1, H. Levine1, D. Sheeter2, C. C. Ignacio1, D. V. Havlir3, D. D. Richman1,4, J. K. Wong1,4 1Univ of California at San Diego, La Jolla; 2Scripps Res Inst, La Jolla, CA; 3San Francisco Gen Hosp, CA; and 4Veterans Affairs San Diego Heatlhcare System, CA |
| 294 | Antibody to LFA-1 Blocks HIV-1 Infection in Primary Cells through the Activation of Caspase 8 L. M. Cimakasky*, J. E. K. Hildreth Johns Hopkins Univ Sch of Med, Baltimore, MD |
| 295 | The Infectivity and Cytopathicity of HIV-1 is Greatly Affected by the Purification State of the Virus B Schweighardt*, J Heymann, E Grace, D Nixon Gladstone Inst of Virology and Immunology, San Francisco, CA |
| 295a | Single Mutation in the N-terminal alpha Helix of SIV Gp41 Expands Coreceptor Usage of Viral Envelope T. Kodama*, S. Jin, M. Murphey-Corb Univ of Pittsburgh, Pittsburgh, PA |