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Session 42
Poster Presentations CD8 T-Cell Responses to HIV/SIV Tuesday 1:30 - 3:30 pm Hall D |
| 302 | Tb4 is an HIV-1 Inhibitory Factor in Transformed CD8+ Cell Supernatants M.E. Klotman*1, A. Mosoian1, A. Teixeira1, T. Chang1, A.A. High2, D.F. Hunt2, J. Shabanowitz2 1Mt Sinai Sch of Med, New York, NY and 2Univ of Virginia Sch of Med, Charlottesville |
| 303 | CD8+ T-cell Responses to Variable Proteins Dominate in Early HIV-1 Infection A. Bansal1, S. Sabbaj1, E. Gough1, D. Ritter1, C. Perkins1, J. Tang1, B. Korber2, R. Kaslow1, C. Wilson1, M. Mulligan1, G. Aldrovandi1, M. Kilby1, P. Goepfert1 1Univ of Alabama at Birmingham and 2Los Alamos Natl Lab, NM |
| 304 | Heightened HIV-1 Replication in Lymphoid Follicles May Be Due to Immune Privilege J. Folkvord, E. Connick* Univ of Colorado Hlth Sci Ctr, Denver |
| 305 | Dynamics of Virus-specific CD8+ T-cell Immunity and Viral Escape during Acute and Chronic HIV-1 Infection J. Cao*1,2, J. McNevin1, Y. Liu2, H. Zhao2, I. Genowati2, J.I. Mullins2, M.J. McElrath1,2 1Fred Hutchinson Cancer Res Ctr, Seattle, WA and 2Univ of Washington, Seattle |
| 306 | Simultaneous Assessment of Degranulation and Cytokine Production in HIV- and CMV-specific CD8+ T-cells Ex Vivo M. Betts*, J. Brenchley, D. Ambrozak, D. Price, D. Douek, M. Roederer, R. Koup Vaccine Res Ctr, NIAID, NIH, Bethesda, MD |
| 307 | HIV-1 Superinfection Despite Broad CD8+ T-cell Responses Containing Replication of the Primary Virus T. M. Allen*1, M. Altfeld1, X. G. Yu1, M. N. Johnston1, D. Agrawal1, B. T. Korber2, D. C. Montefiori3, D. H. O'Connor4, B. T. Davis1, P. K. Lee1, E. L. Maier1, P. J. R. Goulder5, C. Brander1, E. S. Rosenberg1, B. D. Walker1 1Massachusetts Gen Hosp and Partners AIDS Res Ctr, Boston; 2Los Alamos Natl Lab, NM; 3Duke Univ Med Ctr, Durham, NC; 4Wisconsin Reg Primate Res Ctr, Univ of Wisconsin, Madison; and 5Peter Medawar Bldg for Pathogen Res, Oxford, UK |
| 308 | Immune Selection by CTL is an Important Factor for Sequence Variation in HIV-1 Nef T. Harrer*, A. Goldwich, M. Schmitt, M. Bäuerle, S. Bergmann, M. Hamacher, J. R. Kalden, R. Müller, S. Kasten, T. Harrer Univ of Erlangen, Germany |
| 309 | Anti-HIV Gag Specific CTLs Show an Impaired Proliferative Ability in Untreated Chronically HIV-infected Patients J. Benito*, V. Soriano, M. Lopez, S. Lozano, P. Martinez, J. Gonzalez-Lahoz Inst de Salud Carlos III, Madrid, Spain |
| 310 | Identification of HIV-1 Pol Cytotoxic T-lymphocyte Epitopes Containing Drug Resistance Mutations R. Mason*, M. Grant Mem Univ of Newfoundland, St John's, Canada |
| 311 | T-cell Receptor V D. Meyer-Olson*1, M. Altfeld1, K. W. Brady1, S. He1, P. Lee1, R. Dränert1, T. M. Allen1, M. M. Addo1, D. Strick1, E. S. Rosenberg1, B. D. Walker1, S. A. Kalams2 1Partners AIDS Res Ctr, Massachusetts Gen Hosp and Harvard Med Sch, Boston, MA and 2Vanderbilt Univ Med Ctr, Nashville, TN |
| 312 | Induction of HIV-specific CD8+ T-cell Responses in Uninfected Individuals Following Mucosal and Parenteral Exposure to HIV G. Makedonas*1, J. Bruneau2, M. Alary3, C.M. Tsoukas1, C. Lowndes4, F. Lamothe2, Y. Peretz1, N.F. Bernard1 1Immune Deficiency Treatment Ctr, McGill Univ Hlth Ctr Res Inst, Montreal, Canada; 2Res Inst of the Ctr Hosp de Univ de Montreal, Canada; 3Ctr Hosp de l’Univ de Quebec, Canada; and 4HIV and STI Div, PHLS Communicable Disease Surveillance Ctr, Imperial Coll, London, UK |
| 313 | IL-15 Restores Bcl-2 Levels in HIV-specific CD8+ T-cells from HIV-infected Individuals Y. Mueller*1, C. Petrovas1, I. Dimitriou1, P. Bojczuk1, J. Witek1, J. Altman2, P. Katsikis1 1Drexel Univ, Philadelphia, PA and 2Emory Univ, Atlanta, GA |
| 314 | Underestimation of HIV-1 Specific T-cell Responses Directed Against the Autologous Virus using HIV-1 Clade B Consensus Sequences M. Altfeld*, M. M. Addo, P. K. Lee, R. Shankarappa, C. Brander, T. Allen, A. Rathod, X. G. Yu, J. Harlow, K. O’Sullivan, M. N. Johnston, D. Strick, J. I. Mullins, E. S. Rosenberg, B. D. Walker AIDS Res Ctr, MGH, Boston, MA |
| 315 | Recognition of HIV-1 CD8+ T-epitopes in Early Vertical HIV-1 Infection Z. Scott*, K. Luzuriaga Univ of Massachusetts Med Sch, Worcester |
| 316 | Evaluation of Correlates of Protection in HIV-1 Controllers M. M. Addo*1, A. Rathod1, X. G. Yu1, R. Draenert1, M. N. Johnston1, C. Corcoran1, S. Davis1, A. Piechocka-Trocha1, M. Altfeld1, E. S. Rosenberg1, B. D. Walker1, and the HIV-Controller Study Group2 1Partners AIDS Res Ctr, Massachusetts Gen Hosp, Boston, MA and 2Multicenter |
| 317 | HLA-B*35 Restricted CD8+ T-cell Responses May Influence Rates of HIV Disease Progression J Yu* Univ of Rochester, NY |
| 318 | The Differential Ability of Long-term Nonprogressors and Progressors to Restrict HIV Replication is Not Caused by Loss of Recognition of Autologous Viral Sequences S. A. Migueles*1, A. C. Laborico1, H. Imamichi2, W. L. Shupert1, C. Royce1, M. McLaughlin1, L. Ehler1, S. Liu1, J. Metcalf1, M. Connors1 1Lab of Immunoregulation, NIAID, NIH, Bethesda, MD and 2Sci Applications Intl Corp Frederick, NCI, MD |
| 319 | SIV-specific Cytotoxic T-cell Development in SIV Infection R. S. Veazey*1, J. E. Schmitz2, J. D. Lifson3, M. Piatak3, A. A. Lackner1 1Tulane Natl Primate Res Ctr, Tulane Univ Hlth Sci Ctr, Covington, LA; 2Beth Israel Deaconess Med Ctr, Harvard Med Sch, Boston, MA; and 3Sci Applications Intl Corp Frederick, NCI-FCRDC, MD |
| 320 | Spontaneous Sustained Control of SIVmac239 Infection in a SIV-naïve Rhesus Macaque: Immunologic Correlates J. D. Lifson*1, J. L. Rossio1, M. Piatak Jr.1, A. N. Hoffman1, D. M. Schneider1, V. Coalter1, B. Poore1, R. C. Desrosiers2 1AIDS Vaccine Prgm, SAIC Frederick, Inc, NCI, MD and 2New England Natl Primate Res Ctr, Southborough, MA |