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Session 50
Poster Presentations Neutralizing Antibodies Wednesday 1:30 - 3:30 pm Hall D |
| 407 | The Protective Effect of Passively Transferred Neutralizing Antibody in the Setting of Active Cellular Immunity J Mascola*1, M Lewis2, T VanCott3, G Stiegler4, H Katinger4, J Shiver5, P Poignard6, D Burton6, N Letvin7 1Vaccine Res Ctr, NIAID, NIH, Bethesda, MD; 2Southern Res Inst, Frederick, MD; 3Walter Reed Army Inst of Res, Henry M Jackson Fndn, Rockville, MD; 4Inst of Applied Microbiology, Univ of Agriculture, Vienna; 5Merck Res Labs, West Point, PA; 6Scripps Res Inst, La Jolla, CA; and 7Harvard Med Sch, Boston, MA |
| 408 | Induction of Broadly Cross-reactive Primary Isolate Neutralizing Antibodies by Env-CD4 Complexes I. K. Srivastava*, E. Kan, V. Sharma, Y. Sun, J. B. Ulmer, S. W. Barnett Chiron Corp, Emeryville, CA |
| 409 | Ancestral HIV-1-B Env Protein Induces Broadly Neutralizing Antibodies in Rabbits G. Learn*1, N. Doria-Rose1,2, M. Mahalanabis1,2, A. G. Rodrigo3, F. Li1, N. L Haigwood1,2, J. I. Mullins1 1Univ of Washington, Seattle; 2Seattle BioMed Res Inst, WA; and 3Univ of Auckland, New Zealand |
| 410 | Development of a Consensus Env Immunogen for HIV-1 Group M F. Gao*1, Y. Li2, C. M. Rodenburg2, M. Alam1, S. Beddows3, J. P. Moore3, H. X. Liao1, B. F. Haynes1, B. T. Korber4, B. H. Hahn2 1Duke Univ Med Ctr, Durham, NC; 2Univ of Alabama at Birmingham; 3Weill Med Coll of Cornell Univ, New York, NY; and 4Los Alamos Natl Lab, NM |
| 411 | Dichotomy in Cross-clade Reactivity of Sera: Implications for the Development of Active and Passive Immunotherapy L. Cavacini*1, M. Duval1, C. Wood2, K. Mayer3, M. Posner1 1Beth Israel Deaconess Med Ctr and Harvard Med Sch, Boston, MA; 2Univ of Nebraska at Lincoln; and 3Fenway Community Hlth, Boston, MA |
| 412 | Maturation of Humoral Antibody in HIV-1 Subtype B or E Infections Following Seroconversion B. Parekh* CDC, Atlanta, GA |
| 413 | The Nature of Heterologous Neutralization by HIV+ Serum M. Gibson1, C. Skema1, C. McDanal1, J. Kurtzer1, C. Smith1, G. Tomaras1, D. Montefiori1, N. Jack2, F. Cleghorn3, W. Blattner3, K. Weinhold1, C. LaBranche*1 1Duke Univ Med Ctr, Durham, NC; 2Med Res Fndn, Port-of-Spain, Trinidad and Tobago; and 3Inst for Human Virology, Baltimore, MD |
| 414 | Identification of Epitopes Involved in Escape from Neutralizing Antibody G. D. Tomaras*1, D. G. Goodman1, C. B. McDanal1, N. Jack2, F. Cleghorn3, W. A. Blattner3, K. J. Weinhold1, T. J. Mathews1, M. L. Greenberg1 1Duke Univ, Durham, NC; 2Med Res Council, Port of Spain, Trinidad; and 3Inst of Human Virology, Baltimore, MD |
| 415 | Enhanced Immunogenicity to HIV-1 Envelope Using DNA Vaccines J. F. Bower*1, J. Sodroski2, T. Ross1 1East Carolina Univ, Sch of Med, Greenville, NC and 2Dana-Farber Cancer Inst, Boston, MA |
| 416 | Creating Novel HIV-1 gp120 and gp120Core Molecules Sharing Similar Antigenicity to the Native Trimeric Envelope Complex Using DNA Shuffling Technology X. Du*1, L. Xu1, W. Zhang1, P. Parren2, M. Zwick3, D. Burton3, R. Whalen1 1Maxygen, Inc, Redwood City, CA; 2Genmab, Utrecht, The Netherlands; and 3Scripps Res Inst, La Jolla, CA |
| 417 | A Single-round, Recombinant-based Viral Infectivity Assay Allows for the Sensitive and Specific Detection of Biologically Relevant Neutralizing Antibodies to HIV-1 J. Decker*1, X. Wei1, S. Wang1, X. Wu2, B. Hahn2, J. Kappes2, G. Shaw1 1Howard Hughes Med Inst, Univ of Alabama at Birmingham and 2Univ of Alabama at Birmingham |
| 418 | Defining Mechanisms of Antibody-mediated Neutralization of SIV K. S. Cole*1, J. Steckbeck1, K. Miller2, I. Orlov2, J. Bruno2, J. Werkman1, N. Polansky1, B. Puffer3, R. Doms3, R. Montelaro1 1Univ of Pittsburgh, PA; 2BIACORE, Inc, Piscataway, NJ; and 3Univ of Pennsylvania, Philadelphia |
| 419 | SIV env gp140 "Domain-specific" Antibody Responses in Rhesus Macaques Inoculated with Attenuated SIV/17E: A Novel Strategy to Understanding Delayed Humoral Maturation J. Rowles*, K. S. Cole, T. Sturgeon, J. Jin, M. Murphey-Corb, R. C. Montelaro Univ of Pittsburgh Sch of Med, PA |
| 420 | Defined Sequence Variants of Simian Immunodeficiency Virus Strain 239 Reveal Global Effects on Sensitivity to Antibody-mediated Neutralization W. Johnson*1,2, H. Sanford1,2, J. Lifson3, P. Parren4, D. Burton5, J. Robinson6, R. Desrosiers1,2 1New England Reg Primate Res Ctr, Southborough, MA; 2Harvard Med Sch, Boston, MA; 3Sci Applications Intl Corp -Frederick, MD; 4Genmab, The Netherlands; 5Scripps Res Inst, La Jolla, CA; and 6Tulane Univ Med Sch, New Orleans, LA |
| 421 | CD4-independent Co-receptor Use of Sequential SIVsm Isolates Varies with the Neutralizing Antibody Response D. Vödrös*1,2, R. Thorstensson3, R.W. Doms4, E.M. Fenyö2, J.D. Reeves4 1Karolinska Inst, Stockholm, Sweden; 2Lund Univ, Lund, Sweden; 3Swedish Inst for Infectious Disease Control, Stockholm, Sweden; and 4Univ of Pennsylvania, Philadelphia, |