Search Abstracts Program


Session 7   Oral Abstract Presentations
Immune Responses to HIV
Tuesday 10 am - 12:15 pm
Ballroom B
Moderators: Anthony Kelleher Univ of New South Wales, Darlinghurst, Australia and Savita Pahwa North Shore-LIJ Res Inst, Manhasset, NY
10:00       27Stoichiometry of Neutralization of a HIV-1 Primary Isolate by the Anti-CD4 Binding Site Antibody b12s
M. Franti*1, S. Frost2, V. Vivona1, K. Delgado1, L. Ramos1, D. R. Burton1, P. Poignard1
1Scripps Res Inst, La Jolla, CA and 2Univ of California at San Diego
10:15       28Tyrosine Sulfation of Human Antibodies that Bind the CCR5-binding Domain of HIV-1 gp120
H. Choe1, W. Li1, P. Wright1, M. Moore1, N. Vasilieva1, J. Robinson2, J. Sodroski1, M. Farzan*1
1Harvard Med Sch, Cambridge, MA and 2Tulane Univ, New Orleans, LA
10:30       29Migration of T-cells Away from HIV-1 gp120: A New Mechanism for Viral Immune Evasion
D. M. Brainard*1, W. G. Tharp1, I. T. Olszak1, A. Trocha1, S. A. Kalams1, B. D. Walker1, R. Wyatt2, J. Sodroski2, M. C. Poznansky1
1Partners AIDS Res Ctr, Harvard Med Sch, Boston, MA and 2Dana-Farber Cancer Inst, Boston, MA
10:45       30Expression of Lymphocyte Homing Receptors by SIV-specific CD8+ T-cells in the Female Reproductive Tract of Rhesus Macaques
M. Cromwell*1, X. Alvarez2, J. Altman3, S. Westmoreland1, S. Klumpp1, A.Luster4, A. Lackner2, P. Johnson1
1New England Natl Primate Res Ctr, Southborough, MA; 2Tulane Natl Primate Res Ctr, Covington, LA; 3Emory Vaccine Ctr at Yerkes, Atlanta, GA; and 4Massachusetts Gen Hosp, Harvard Med Sch, Boston
11:00       31Comprehensive Analysis of HIV-specific CD4 Responses by IFN-gamma ELISpot in Early Chronic HIV-1 Infection Shows Marked Immunodominance of gag and nef and the Presence of Broadly Recognized Peptides
D. Kaufmann*1, P. Bailey1, L. Cosimi2, P. Norris1, M. Addo1, M. Altfeld1, H. Truong1, M. Johnston1, C. Brander1, B. Walker1, E. Rosenberg1
1Partners AIDS Res Ctr, Massachusetts Gen Hosp, Boston, MA and 2Brigham and Women's Hosp, Boston, MA
11:15       32Functional Discrepancies in HIV-specific CD8+ T-lymphocyte Populations Reflect the Kinetics of Virus Exposure
D. A. Price*1, A. Oxenius2, A. K. Sewell3, S. J. Dawson3, H. F. Guenthard4, M. Fischer4, G. M. Gillespie3, S. L. Rowland-Jones3, R. A. Koup1, C. Fagard5, B. Hirschel5, D. C. Douek1
1Vaccine Res Ctr, NIH, Bethesda, MD; 2ETH Zentrum, Zurich, Switzerland; 3Univ of Oxford, UK; 4Univ Hosp, Zurich, Switzerland; and 5Univ Hosp, Geneva, Switzerland
11:30       33Relationship Between Functional and Qualitative Abnormalities within the Pool of HIV-1 Specific Memory CD4 T-cells and Control of HIV-1 Disease
A. Harari*, S. Petitpierre, M. Khonkarly, P. A. Bart, G. Pantaleo
Lab of AIDS Immunopathogenesis, Lausanne, Switzerland
11:45       34Systematic Microarray Analysis Reveals Counter Balance between Perforin and Interleukin 7 Receptor with Progression of HIV Infection
F. Boutboul1, D. Puthier2, C. Nguyen2, H. Ait Mohand3, C. Katlama3, G. Carcelain1, P.Debré1, I. Hirsch4, B.Autran*1
1Immunol Cell, Univ Pitié Salpétrière, Paris, France; 2INSERM ERM 206, Marseille, France; 3Hosp Pitié Salpétrière, Paris, France; and 4INSERM U372, Marseille, France
12:00       35Vigorous HIV-specific CD8 T-cell Responses in Late Stage HIV Infection
R. Draenert*1, Y. Tang1, C. Verrill1, A. Wurcel1,2, M. Boczanowski1, A. Rathod1, M. Addo1, B. Walker1
1Partners AIDS Res Ctr, Boston, MA and 2Lemuel Shattuck Hosp, Jamaica Plain, MA