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Session 82
Poster Presentations Microbicides Tuesday 1:30 - 3:30 pm Hall A |
| 673 | R5 HIV Infection of Langerhans Cells within Epithelial Tissue Explants Is Regulated by Compound CCR5 Polymorphisms and Is Blocked by Chemically Modified RANTES Analogues B T. Kawamura1, O. Hartley2, F. O. Gulden3, D. T. McNamara3, D. L. Borris1, M. M. Lederman3, R. E. Offord2, P. A. Zimmerman3, A. Blauvelt*1 1Natl Cancer Inst, Bethesda, MD; 2Univ of Geneva, Switzerland; and 3Case Western Reserve Univ, Cleveland, OH |
| 674 | IL-8 Antagonists Decrease Susceptibility to HIV-1 in Cervical Explant Tissue B. Patterson*1, D. Derbin1, A. Landay2, Z. Flener1 1Children's Mem Hosp, Northwestern Univ, Chicago, IL and 2Rush Med Coll, Chicago, IL |
| 675 | Antibody to ICAM-1 Blocks Sexual Transmission of Cell-associated HIV-1 C. J. Chancey*1, K. V. Khanna1, J. E. Hildreth2, R. B. Markham1 1Johns Hopkins Sch of Publ Hlth, Baltimore, MD and 2Johns Hopkins Sch of Med, Baltimore, MD |
| 676 | Protection of Macaques from SHIV Infection by Vaginal Application of Anti-gp120 Monoclonal Antibody b12 R. S. Veazey*1, R. J. Shattock2, M. Pope3, P. J. Klasse4, J. C. Kirijan1, J. Jones3, P. A. Marx1, D. R. Burton5, J. P. Moore6 1Tulane Natl Primate Res Ctr, Tulane Univ Hlth Sci Ctr, Covington, LA; 2St George's Hosp Med Sch, London, UK; 3Ctr for BioMed Res, The Population Council, NY; 4Jefferiss Res Trust Labs, Wright-Fleming Inst, Imperial Coll, London, UK; 5Scripps Res Inst, La Jolla, CA; and 6Weill Med Coll of Cornell Univ, New York, NY |
| 677 | Candidate Microbicide Formulations of the HIV-1 Inhibitor UC-781 Block Localized HIV-1 Infection and Dendritic Cell Dissemination Pathways within Human Cervical Tissue P. Watts*2, J. Romano1, G. Wallace2, M. Aydelotte1, G. Cohl1, R. Schnaare1, B. Burruano1, R. Shattock2 1Biosyn, Inc, Huntingdon Valley, PA and 2St George's Hosp Med Sch, London, UK |
| 677a | hu-SCID Mice Vaginal/Rectal Model for Safety and Efficacy Testing of Topical Microbicides: Inhibition of HIV-1 Transmission by Gel Containing an NNRTI - TMC120. Simonetta Di Fabio*1, Giacomo Giannini1, Jens Van Roey2, A. Binelli1, M. Spada1, Guy Van den Mooter3, Caterina Lapenta1, P. Sestili1, M.P. Pirillo1, F. Belardelli1, E. Proietti1, Marie-Pierre de Bethune2, Stefano Vella1 1Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy; 2Tibotec-Virco NV, Mechelen, Belgium; and 3Laboratorium voor Farmacotechnologie en Biofarmacie, University of Leuven, Belgium |