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Session 37
Poster Presentations RNAi, Lentvirus Vectors, and Gene-Based Therapy Tuesday 1:30 - 3:30 pm Hall D |
| 220 | Modulating the HIV-1 Replication Cycle Through RNAi Jean-Marc Jacque*, Mario Stevenson Prgm in Molecular Med, Univ of Massachusetts Med Sch, Worcester, MA, USA, 01605 |
| 221 | RNA Interference of Chemokine Receptor Expression Allows for Inhibition of HIV-1 Replication MA Martinez1, A Gutierrez1, M Armand-Ugon1, J Blanco1, M Parera1, J Gomez2, B Clotet1, J.A. Este*1 1Fundacio IrsiCaixa, Barcelona, Spain and 2Hosp Vall d'Hebron, Barcelona, Spain |
| 222 | CXCR4 Gene Silencing with Multiple Small Interfering RNAs Inhibits HIV-1 Infection J. Ji*, P. Erb, T. Klimkait, M. Wernli Inst Med Microbiology, Basel, Switzerland |
| 223 | Inhibition of CCR5 Expression Using RNA Interference Selectively Blocks Infection by R5-Tropic HIV-1 M. T. M Lee*, B. R. Cullen Howard Hughes Med Inst (HHMI) and Duke Univ Med Ctr, Durham, NC |
| 224 | Silencing Gene Expression by Short Interfering RNA Targeting NF-kB Binding Site within 5’ LTR K Suzuki*1, S Suter2, R Ward2, D Cooper3, A Kelleher3 1Ctr for Immunology, St Vincent's Hosp, Daringhurst, Australia; 2Med Oncology, St Vincent’s Hosp, Australia; and 3Natl Ctr for HIV Epidemiological and Clin Res, Sydney, Australia |
| 225 | Sustained siRNA-mediated HIV Inhibition in Primary Macrophages P. Shankar*1, E. Song1, S.K. Lee1, D.M. Dykxhoom2, C. Novina2, K. Crawford1, J. Cerny1, P.A. Sharp2, J. Lieberman1, M.N. Swamy1 1Ctr for Blood Res, Harvard Med Sch, Boston, MA and 2Ctr for Cancer Res, MIT, Cambridge, MA |
| 226 | Combination Therapies Targeting CCR5 Using RNAi, Antibody, and Ribozymes Delivered by rSV40 Vectors Pierre Cordelier*1, Barry A. Morse Jr1, Joseph Kukowski1, Mohammad BouHamdan1, Roger J. Pomerantz 1, John Rossi2, David S. Strayer1 1Jefferson Med Coll, Philadelphia, PA and 2City of Hope, Beckman Inst, Duarte, CA |
| 227 | Lentiviral Vectors Interfering with CD4 Down-modulation as an Anti-HIV Approach B. Gröschel*, M.J. Cortés, E. Argańaraz, J. Lama Univ of California at San Diego, La Jolla |
| 228 | Lentivirus Packaging and Gene Transfer Vectors S. K. Arya*, J. E. Cho, A. Zamani Natl Cancer Inst, NIH, Bethesda, MD |
| 229 | The HIV-1 cPPT/CTS Fragment Mediates Efficient Transgene Expression from Lentiviral Vectors J van Griensven*, B Van Maele, E De Clercq, Z Debyser Rega Inst for Med Res, Katholieke Univ Leuven, Belgium |
| 230 | A Comprehensive Approach to Gene Therapy of HIV Infection J. van Lunzen*1, G. Brandenburg2, C. Baum3, M. Egelhofer4, K. Kühlcke4, H. Martinius5, P. Schult-Dietrich5, F. Vorpahl5, A. Alexandrov5, D. von Laer2 1Univ Hosp Eppendorf, Hamburg, Germany; 2Georg-Speyer-Haus, Frankfurt, Germany; 3Med Hochschule Hannover, Germany; 4Eufets AG, Idar-Oberstein, Germany; and 5Fresenius HemoCare, Martinsried, Germany |
| 231 | Biological Therapy of HIV/AIDS Using HIV-based Vectors Containing Anti-HIV Genetic Payloads B. Dropulic*1,2, L. Humeau1, X. Lu1, V. Slepushkin1, B. Levine3, Q. Yu1, Y. Ni1, B. Davis1, R. Carroll3, Y. Chang1, C. June3 1VIRxSYS Corp, Gaithersburg, MD; 2Kimmel Cancer Ctr at Johns Hopkins, Johns Hopkins Univ Sch of Med, Baltimore, MD; and 3Abramson Family Cancer Res Inst, Univ of Pennsylvania, Philadelphia |
| 231a | Inhibition of HIV Infection in CD4 T-cells by Lentiviral-mediated Delivery of anti-CCR5 siRNA is Influenced by CCR5 Expression
C. Butticaz1, A. Ciuffi1, M. Munoz1, J. Thomas1, R. Iggo2, P. Meylan1, A. Telenti*1 1Infectious Diseases and Microbiology, CHUV, Lausanne, Switzerland and 2Swiss Cancer Research Institute, Epalinges, Switzerland |
| 231b | Efficient Inhibition of HIV-1 Replication by RNA Interference Thijn R. Brummelkamp1, Atze T. Das2, Monique Vink2, René Bernards1, Ben Berkhout*2 1Dutch Cancer Institute, Amsterdam, the Netherlands and 2AMC, University of Amsterdam, the Netherlands |
| 231c | Inhibition of HIV-1 Replication by Stable Cellular Expression of tat –Specific Short Interfering RNA. Daniel Boden*, Oliver Pusch, Frederick Lee, Lynne Tucker, Peter Shank, Bharat Ramratnam Brown Medical School, Providence, RI, USA |