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Session 45
Poster Presentations Immune Response Changes following Antiretroviral Therapy Wednesday 1:30 - 3:30 pm Hall D |
| 342 | Perforin-Expressing CD4+ T-cells are Found in Oligoclonal Expansions and Decline in the Setting of HAART L. Goodwin*1, S. Bennett1, E. Connick1, B. Kotzin1, ACTG 315/375 Study Team2 1Univ of Colorado Hlth Sci Ctr, Denver and 2Adult AIDS Clin Trials Group, Washington, DC |
| 343 | Different Levels of Immune Activation in Naive and Memory Subsets of CD4 and CD8 T-lymphocytes in Chronic HIV Infection-Effects of Antiretroviral Therapy J. Benito*, M. Lopez, S. Lozano, P. Martinez, J. Gonzalez-Lahoz, V. Soriano Inst de Salud Carlos III, Madrid, Spain |
| 344 | Spontaneous Apoptosis of T-lymphocytes Fails to Normalize on Long-term HAART and Strongly Predicts the Recovery of CD4 T-lymphocytes G. Kaufmann*1, N. Hansjee2, C. Strub1, R. Weber3, M. Battegay1, P. Erb2 1Univ Hosp Basel, Switzerland; 2Inst for Med Microbiology, Basel, Switzerland; and 3Univ Hosp Zurich, Switzerland |
| 345 | Lymphoproliferative Responses to HIVp24 in Chronically HIV-1 Infected Patients Treated with HAART Reflect Low-level Viral Replication but Not an Improvement in Indices of Immune Phenotype or Function C. G. Lange*1,2, B. K. Patterson3, B. Harnish4, K. Medvik1, Z. Xu4, R. Asaad1, H. Valdez1, S. J. Lee5, A. Landay6, J. Lieberman4, M. M. Lederman1 1Ctr for AIDS Res, Case Western Reserve Univ, Univ Hosp of Cleveland, OH; 2Med Clin, Res Ctr, Borstel, Germany; 3Children´s Mem Hosp, Northwestern Univ Med Sch, Chicago, IL; 4Ctr for Blood Res, Harvard Med Sch, Boston, MA; 5Dana-Farber Cancer Inst, Boston, MA; and 6Rush Med Coll, Chicago, IL |
| 346 | Older Age is Associated with Reduced Naïve T-cell Responses to Antiretroviral Therapy: 48-week Results of ACTG Protocol 5015 R. Kalayjian*1, M. M. Lederman2, R. B. Pollard3, M. Pu4, J. Spritzler4, V. Stocker6, M. Chernoff4, S. Fiscus7, D. Taub8, V. Valcour9, N. Mantz10, F. Rousseau11, J. Olsen12, S. Brun13, A. Landay14 1MetroHlth Med Ctr, Cleveland, OH; 2Case Western Reserve Univ, Cleveland, OH; 3Univ of California at Davis, Sacramento; 4Harvard Sch of Public Hlth, Boston, MA; 6AACTG Operations, Rockville, MD; 7Univ of North Carolina, Chapel Hill; 8Natl Inst of Aging, Bethesda, MD; 9Univ of Hawaii, Honolulu; 10Univ of Pittsburg, PA; 11Triangle Pharm, Inc, Durham, NC; 12Bristol-Myers Squibb, Plainsboro, NJ; 13Abbott Labs, Chicago, IL; and 14Rush Med Coll, Chicago, IL |
| 347 | Shifting Pressure Affects the Frequency of CD8+ T-cell Escape Variants with Initiation of HAART J. Casazza*, M. Betts, B. Hill, J. Brenchley, D. Ambrozak, D. Douek, R. Koup Vaccine Res Ctr, NIH, Bethesda, MD |
| 348 | Suppression of HIV Replication with HAART Can Induce de novo Appearance of HIV-specific CTLs in Patients with Chronic HIV Infection M. Lopez*, V. Soriano, J. Benito, S. Lozano, P. Martinez, J. Gonzalez-Lahoz Inst de Salud Carlos III, Madrid, Spain |
| 349 | Repertoire of HIV-1 p24 Epitopes Targeted by CD4+ T-cells in HIV-1 Infected Subjects Either Receiving or Not Receiving Antiretroviral Therapy E. Boritz*, B. Palmer, C. Wilson Univ of Colorado Hlth Sci Ctr, Denver |
| 350 | HIV-specific Cytotoxic T-lymphocyte Epitope Responses in HIV-infected Children on HAART N. Ching*, B. Ank, O. Yang, K. Nielsen, J. Deville, Y.J. Bryson Univ of California at Los Angeles |
| 351 | Predictors of HIV-specific Immune Responses in Chronically HIV-infected Subjects on Antiretroviral Therapy A. Siddique*1, E. Dragileva1, K. E. Hartman1, J. Campagna1, D. W. Cherng2, M. Dondero3, L. Peiperl4, F. Valentine5, S. A. Kalams6 1Partners AIDS Res Ctr and Massachusetts Gen Hosp, Boston, MA; 2Statistical and Data Analysis Ctr, Boston, MA; 3AACTG Operations Ctr, Silver Spring, MD; 4Univ of California at San Francisco, AIDS Clin Trials Unit; 5New York Univ Med Ctr; and 6Partners AIDS Res Ctr and Vanderbilt Univ Med Ctr, Nashville, TN |
| 352 | Protease Inhibitor-containing HAART is Associated with Decreased In Vivo T-cell Activation Independent of its Effects on Viral Replication P. Hunt*, J. Martin, D. Bangsberg, A. Moss, E. Sinclair, B. Bredt, S. Deeks Univ of California at San Francisco |
| 353 | HAART Alters the Natural Evolution of the Pattern of HIV-specific Immune Responses in Subjects Starting HAART in Primary HIV Infection G. Alter*1, G. Hatzakis1, C. M. Tsoukas1, D. Rouleau2, R. P. LeBlanc1, J.-G. Baril3, H. Dion4, E. Lefebvre4, R. Thomas4, P. Côté3, J.-P. Routy1, R.-P. Sékaly5, N. F. Bernard1 1McGill Univ Hlth Ctr, Montreal, Canada; 2Ctr Hosp de l’Univ de Montreal, Canada; 3Clin Med du Quartier Latin, Montreal, Canada; 4Clin l’Actuel, Montreal, Canada; and 5Univ of Montreal, Canada |
| 354 | Treatment, Immunological Changes, and Pregnancy Outcome S. Fiore*1, M.-L. Newell1, D. Trabattoni2, V. Savasi2, C. Tibaldi3, C. Lanzani2, V. Conserva2, E. Ferrazzi2, M. Clerici2 1Univ Coll of London, UK; 2Univ of Milan, Italy; and 3Univ of Turin, Italy |
| 355 | Immunologic Evidence that Start of ART can be Deferred for CD4 T-cell Count < 200/ M. Nobile*, R. Correa, K. Ellefsen-Lavoie, E. Aschwanden, M. Spasojevic, C. D'Agostino, L. Codarri, M. Khonkarly, G. Pantaleo Lab of AIDS Immunopathogenesis, CHUV, Lausanne, Switzerland |