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Session 6
Oral Abstract Presentations HIV Replication: Entry and Assembly Tuesday 10 am - 12:30 pm Ballroom A |
| Moderators: | Betty Poon David Geffen Sch of Med, Univ of California, Los Angeles and Ronald Desrosiers New England Regional Primate Res Ctr, Harvard Med Sch, Southborough, MA |
| 10:00 17 | Inside-out Regulation of HIV-1 Particle Fusion Christopher Aiken*1, Donald J. Wyma1, Janet E. Lineberger2, Michael D. Miller2 1Vanderbilt Univ Sch of Med, Nashville, TN and 2Merck Res Labs, West Point, PA |
| 10:15 18 | Disruption of Lipid Rafts in HIV-producing Cells Impairs Fusion of HIV-1 Virions To Target Cells M. Cavrois*1, W. Yonemoto1, D. Fenard1, J. Neidleman 1, W. Greene1,2 1Gladstone Inst of Virology and Immunology, San Francisco, CA and 2Univ of California at San Francisco |
| 10:30 19 | Mutations in the Cytoplasmic Domain of the SIV Transmembrane Molecule can Dramatically Increase Envelope Content in Virions, Infectivity, and Resistance to Antibody-mediated Neutralization E. Yuste*, R. Desrosiers Harvard Med Sch New England Regional Primate Res Ctr, Southborough, MA |
| 10:45 20 | Recruitment of CD4, CCR5, Rafts, and Ezrin in Actin-dependent Cell Surface Structures: Implications for HIV Fusion and Entry Events C.M. Steffens*, T.J. Hope Univ of Illinois at Chicago |
| 11:00 21 | In Vitro De-evolution of the HIV Envelope Glycoprotein to Functional Core Elements with Deletions of V1/V2 and V3 Hypervariable Loops G. Lin*, B. S. Haggarty, J. Romano, P. J. Vance, J. A. Hoxie Univ of Pennsylvania, Philadelphia |
| 11:15 22 | A Novel Potent CD4-induced Monoclonal Antibody (E51) Active against Primary HIV-1 Strains S.-H. Xiang*1, M. Abreu1, J. Robinson2, J. Sodroski1 1Dana-Farber Cancer Inst, Boston, MA and 2Tulane Univ Med Ctr, New Orleans, LA |
| 11:30 23 | Sensitivity of HIV-1 to Entry Inhibitors Correlates with Envelope: Co-receptor Affinity, Co-receptor Density, and Fusion Kinetics J. Reeves*1, S. Gallo2, N. Ahmad1, J. Miamidian1, P. Harvey1, M. Sharron1, S. Pöhlmann1, T. Pierson1, M. Biscone1, J. Sfakianos3, C. Derdeyn3, G. Tomaras4, R. Blumenthal2, E. Hunter3, R. Doms1 1Univ of Pennsylvania, Philadelphia; 2Natl Cancer Inst, Frederick, MD; 3Univ of Alabama at Birmingham; and 4Duke Univ, Durham, NC |
| 11:45 24 | The Role of ESCRT-I in Retroviral Budding Juan Martin-Serrano*, Trinity Zang, Paul D. Bieniasz Aaron Diamond AIDS Res Ctr, Rockefeller Univ, New York, NY |
| 12:00 25 | Cleavage at the N-terminus of the HIV Protease is Modulated by the Beta-sheet Structure of the Dimer Interface A.H.Kaplan*, S.C.Pettit Univ of North Carolina Sch of Med, Chapel Hill |
| 12:15 26lb | PML and the Proteasome as Meiators of Intracellular Antiretroviral Innate Immunity P. Turelli, D Trono* Univ of Geneva, Switzerland |