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Session 9 Oral Abstracts and Mini-Lecture
Neuropathogenic Manifestations of HIV Infection
Monday, 10 am - 12:30 pm
Presentation Time: 11:45 am
Room 2011


33LB
Progressive White Matter Loss Suggests Ongoing Brain Injury in ART-treated HIV+ Patients
M W Weiner*1, D J Meyerhoff1, V Cardenas-Nicolson1, J Kornak1, C Studholme1, D Truran1, J Rothlind1, L Chao1, H Lampiris1, R Grant4, and J Lindgren1
1VA Med. Ctr., Univ. of California, San Francisco, USA and 4San Francisco General Hosp., Gladstone Inst. of Virology and Immunology, Univ. of California, San Francisco, USA

Background:  Prior to ART, the CNS was a major target of HIV, often producing dementia. Since introduction of ART, CNS complications of HIV have been much less severe. Nevertheless, there has been concern that CNS injury may occur despite ART treatment. Therefore, the goal of this longitudinal study was to test the hypothesis of ongoing CNS injury in both light drinking (LD) and heavy drinking (HD) ART-treated HIV+ subjects compared with HIV- controls.

Methods:  To measure CNS injury, all subjects had structural MRI, MR spectroscopy, neuropsychological tests, and EEG evoked response at 2 time points. Data were analyzed using linear mixed effects models. The demographics of the 4 subject groups are shown in the table:

 

 

N

Age

% Male

Interscan Interval (years)

CD4 Count

Log VL

HIV- LD

45

41±8

64

2.05±0.21

813±280

N/A

HIV- HD

24

43±10

83

1.84±0.16

895±314

N/A

 

Keywords: Brain; MRI; MR spectroscopy