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50 Dyslipidemia, Osteopenia and Changes in Body Habitus in HIV-Infected Women Ellie E Schoenbaum Montefiore Med Ctr, Albert Einstein Sch of Med, Bronx, NY, USA |
Background: Since the advent of HAART, dyslipidemia, osteopenia, and changes in body habitus have been observed in HIV-infected women and men. Studies have linked these findings to anti-retroviral medications, HIV itself, and classic risk factors seen in an aging population. For women with HIV, menopause increases the risk of these outcomes, and postmenopausal weight gain and increased adiposity complicate the analysis of these phenomena. Methods: This presentation will summarize current relevant data from ongoing prospective studies of HIV-infected women, including the WIHS (Women Interagency HIV Study), a multi-center prospective study of ~3000 women, and the Ms. Study, a prospective study of 624 midlife aged women in the Bronx, New York. Results: Among the findings found to date are an earlier onset of menopause and a high body mass index (mean 28.6) among HIV-infected women. Both studies have found that PI use does not exert a major affect on body habitus in women. The Ms. Study has found no PI affect on intima media thickness or decrease in bone mineral density. Conclusions: Ongoing studies will continue to monitor factors associated with dyslipidemia and preclinical atherosclerosis, osteopenia and body habitus changes in aging HIV-infected women, to suggest prevention strategies.
Keywords: HAART in children ; NNRTI-based HAART; Resource limited settings
