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Session 10
Oral Abstracts and Mini-Lecture Transmission, Selection, and Persistence of Drug-Resistant Virus Monday, 10 am - 12:15 pm Room 3000 |
| Moderators | Francoise Brun-Vezinet Bichat-Claude Bernard Hosp, Paris, France Richard Harrigan British Columbia Ctr for Excellence in HIV/AIDS, Vancouver, Canada |
| 10:00 am 35LB | Continuing High-risk Sexual Behavior and Increasing Antiretroviral Resistance among HIV+ Patients in Care Helps Explain the Rising Prevalence of Resistance among New HIV Infections M Kozal*1,2, R Amico3, J Chiarella4, T Schreibman4, D Cornman3, W Fisher5, J Fisher3, and G Friedland4 1Yale Univ. Sch. of Med., New Haven, CT, USA; 2VA Connecticut Healthcare System, New Haven, USA; 3Univ. of Connecticut, Storrs, USA; 4Yale Univ. Sch. of Med., New Haven, CT, USA; and 5Univ. of Western Ontario, Canada |
| 10:15 am 36LB | Persistence of Transmitted Drug-resistant Virus among Subjects with Primary HIV Infection Deferring Antiretroviral Therapy S J Little*1, K K Koelsch1, C C Ignacio1, J K Wong1,2, Y Lie3, S D W Frost1, and D D Richman1,2 1Univ. of California, San Diego, La Jolla, USA; 2San Diego VA Healthcare System, La Jolla, CA, USA; and 3ViroLogic, Inc., South San Francisco, CA, USA |
| 10:30 am 37 | Emergence and Long-term Persistence of NNRTI-resistant Variants in Patients Starting and Stopping NNRTI-containing Regimens S Palmer*1, V Boltz1, F Maldarelli1, E Halvas2, J Mican3, J Mellors2, and J Coffin1 1HIV Drug Resistance Prgm., NCI, NIH, DHHS, Frederick, MD, USA; 2Univ. of Pittsburgh, PA, USA; and 3Lab. of Immunoregulation, NIAID, NIH, DHHS, Bethesda, MD, USA |
| 10:45 am 38 | HIV Resistance and Transmission following Single-dose Nevirapine in a PMTCT Cohort N Martinson*1,2,3, L Morris1,2,3, G Gray1,2, D Moodley4, P Lupondwana1,2, C Chezzi1,2, S Cohen1, C Pillay1,2, A Puren1, M Ntsala1, J Sullivan5, J Steyn2, and J McIntyre2 1Natl. Inst. for Communicable Diseases, Johannesburg, South Africa; 2Perinatal HIV Res. Unit, Johannesburg, South Africa; 3Sch. of Med., Johns Hopkins Univ., Baltimore, MD, USA; 4King Edward Hosp., Durban, South Africa; and 5Univ. of Massachusetts Med. Sch., Worcester, USA |
| 11:00 am 39 | Low-frequency NNRTI-resistant Variants Contribute to Failure of Efavirenz-containing Regimens J Mellors*1, S Palmer2, D Nissley2, M Kearney2, E Halvas1, C Bixby1, L Demeter3, S Eshleman4, K Bennett5, S Hart6, F Vaida5, M Wantman5, J Coffin2, and S Hammer for the ACTG 398 Study Group7 1Univ. of Pittsburgh, PA, USA; 2Drug Resistance Prgm., NCI, NIH, DHHS, Frederick, MD, USA; 3Univ. of Rochester, NY, USA; 4Johns Hopkins Univ., Baltimore, MD, USA; 5Harvard Sch. of Publ. Hlth., Boston, MA, USA; 6Frontier Sci. and Technology Res. Fndn., Amherst, NY, USA; and 7Columbia Univ., New York, NY, USA |
| 11:15 am 40LB | A Randomized, Double-blind Trial Assessing the Efficacy of Single-dose Perinatal Nevirapine Added to a Standard Zidovudine Regimen for the Prevention of Mother-to-child Transmission of HIV-1 In Thailand M Lallemant*1, G Jourdain2, S Le Coeur3, J Y Mary4, N Ngo-Giang-Huong2, S Koetsawang5, S Kanshana6, K McIntosh7,8, V Thaineua6, and the Perinatal HIV Prevention Trial (Thailand) 1PHPT- Inst. de Recherche pour le Développement, France and Thailand; 2Harvard Sch. of Publ. Hlth., Boston, MA, USA; 3Inst. Natl. d’Etudes Démographiques, Paris, France; 4INSERM Erm 0321, Paris, France; 5Family Hlth. Res. Ctr., Mahidol Univ., Bangkok, Thailand; 6Ministry of Publ. Hlth., Bangkok, Thailand; 7Children’s Hosp., Boston, MA, USA; and 8Harvard Med. Sch., Boston, MA, USA |
| 11:30 am 41LB | Exposure to Intrapartum Single-dose Nevirapine and Subsequent Maternal 6-Month Response to NNRTI-based Regimens G Jourdain*1, N Ngo-Giang-Huong1, P Tungyai2, A Kummee2, C Bowonwatanuwong3, P Kantipong3, P Lechanachai4, S Hammer5, M Lallemant2, and Perinatal HIV Prevention Trial Group 1Harvard Sch. of Publ. Hlth., Boston, MA, USA; 2PHPT-Inst. de Recherche pour le Développement, France and Thailand; 3Ministry of Publ. Hlth., Bangkok, Thailand; 4Chiang Mai Univ., Faculty of Associated Med. Sci., Thailand; and 5Columbia Univ. Med. Ctr., New York, NY, USA |
| 11:45 am 42 | Maternal and Infant Treatment Strategies for Preventing MTCT Elaine Abrams Harlem Hosp Ctr, Columbia Univ New York, NY, USA |