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Session 16   Oral Abstracts
Viral Genes and Cellular Co-Factors
Tuesday, 10 am - 12:30 pm
Room 2008
Moderator John Coffin
HIV Drug Resistance Prgm, NCI-FCRDC, Frederick, MD, USA and Tufts Univ, Boston, MA, USA
10:00 am       62HIV-1 Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting its Degradation in the Ubiquitin-Proteasome Pathway
A Mehle*1,2, B Strack1,2, P Ancuta1,2, and D Gabuzda1,2
1Dana-Farber Cancer Inst., Boston, MA, USA and 2Harvard Med. Sch., Boston, MA, USA
10:15 am       63Characterization of Mutations Generated by APOBEC3G on HIV-1 DNA
Q Yu*1, R König1, S Pillai2, M Kearney3, S Palmer3, D Richman2, J Coffin3, and N R Landau1
1Salk Inst. for Biological Studies, La Jolla, CA, USA; 2Univ. of California, San Diego, USA; and 3NCI, NIH, DHHS, Frederick, MD, USA
10:30 am       64AIP1 and ESCRT-III Are Components of the HIV-1 Budding Machinery
B Strack, A Calistri, E Popova, S Craig, and H Gottlinger*
Dana-Farber Cancer Inst., Boston, MA, USA
10:45 am       65Cell-type-specific Targeting of HIV-1 Gag: Evidence of a Role for PIP2
A Ono*, and E O Freed
NCI-FCRDC, NIH, DHHS, Frederick, MD, USA
11:00 am       66Visualization of HIV-1 P55-GFP In Living Cells
C Y Gomez*, and T J Hope
Univ. of Illinois at Chicago, USA
11:15 am       67Capsid Determines the Infectivity of Retroviruses in Nondividing Cells by Mediating Nuclear Transport of Incoming Virions
M Yamashita*, and M Emerman
Fred Hutchinson Cancer Res. Ctr., Seattle, WA, USA
11:30 am       68Characterization of the Role of LEDGF during HIV Replication
Z Debyser*1, S Emiliani2, B Van Maele3, J Vercammen4, M Maroun2, K Busschots3, P Cherepanov3, E De Clercq3, J C Rain5, and R Benarous6
1The European TRIoH Consortium, Rega Inst. for Med. Res., Katholieke Univ. Leuven, Belgium; 2Inst. Cochin, Paris, France; 3Rega Inst. for Med. Res., Katholieke Univ. Leuven, Belgium; 4Lab. for Molecular Dynamics, Katholieke Univ. Leuven, Belgium; 5The European TRIoH Consortium, Hybrigenics S.A., Paris, France; and 6The European TRIoH Consortium, Inst. Cochin, Paris, France
11:45 am       69HIV-1 Nef Mediates Vascular Endothelial Cell Signals Greatly Enhancing HIV-1 Replication in Extra-nodal CD4+ Memory T cells
J Walker*, J Choi, S Boichuk, N Kirkiles-Smith, J S Pober, and L Alexander
Yale Univ., New Haven, CT, USA
12:00 pm       70Replication-competent Variants of HIV-2 with Deletions of the V3 Hypervariable Loop
A Bertolotti-Ciarlet*, G Lin, M Biscone, B Haggarty, J Romano, R W Doms, and J A Hoxie
Univ. of Pennsylvania, Philadelphia, USA
12:15 pm       71Mimicking an Integrin Receptor Signal, HIV-1 Nef Recruits the PcG Protein Eed to Activate HIV Transcription
V Witte*1, B Laffert1, K Blume1, M Sixt1, O Rosorius2, P Lischka2, and A S Baur1
1Univ. of Erlangen, Germany and 2Inst. of Clin. and Molecular Virology, Univ. of Erlangen, Germany