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Session 42   Poster Abstracts
HLA and Immunity
Monday, 1:30 - 3:30 pm
Poster Hall
220A Minority of HLA-B Alleles Dominate the Anti-C Clade HIV-specific Cytotoxic T Lymphocyte Response
P Kiepiela*1, N Mngqundaniso1, C Day2, D Ramduth1, M M Addo2, P Chetty1, N Nene1, N Ntumba1, C Brander2, J Harlow2, C Henry1, I Honeyborne1, M Altfeld2, B D Walker2, and P J R Goulder1,2,3
1HIV Pathogenesis Prgm., Univ. of Natal, Durban, South Africa; 2Partners AIDS Res. Ctr., Howard Hughes Med. Inst., Massachusetts Gen. Hosp., Harvard Med. Sch., Boston, USA; and 3Nuffield Dept. of Med., Pathogen Res., Oxford, UK
221Immunodominance of HLA-A*1101-restricted HIV-specific CD8+ T-cell Responses in Thai Patients
P Hansasuta*1, S Ruangdachsuwan1, S Buranapraditkun1, K Ruxrungtham1, and S L Rowland-Jones2
1Chulalongkorn Univ., Bangkok, Thailand and 2Oxford Univ., UK
222
Quantifiable, HIV-specific CTL Responses Explain HLA-related Risk of Progression to AIDS
A Scherer*1,2, A Oxenius3, D A Price4, H F Guenthard5, B Hirschel6, R E Phillips7,8, A McLean1, and Swiss HIV Cohort Study
1Oxford Univ., UK; 2Eidgenoessische Technische Hochschule Zuerich (EHTZ), Zurich, Switzerland; 3Inst. for Microbiology, ETHZ, Zurich, Switzerland; 4Vaccine Res. Ctr., NIAID, NIH, DHHS, Bethesda, MD, USA; 5Univ. Hosp. Zurich, Switzerland; 6Univ. Hosp. Geneva, Switzerland; 7Nuffield Dept. of Clin. Med., John Radcliffe Hosp., Oxford, UK; and 8Pathogen Res., Oxford, UK
223Population Genetics of Rural Rainforest Inhabitants In Cameroon with High HIV-1 Genetic Diversity
J Torimiro*1, J Carr2, N Wolfe3, P Karachi4, B Kim2, E Mpoudi5, D Birx6, D Burke3, and M Carrington4
1London Sch. of Hygiene and Tropical Med., UK; 2Henry M. Jackson Fndn. for the Advancement of Military Med., Rockville, MD, USA; 3Bloomberg Sch. of Publ. Hlth., Johns Hopkins Univ., Baltimore, MD, USA; 4NCI, NIH, DHHS, Frederick, MD, USA; 5Army Hlth. Res. Ctr., Yaounde, Cameroon; and 6Walter Reed Army Inst. of Res., Rockville, MD, USA
224A Novel Escape Mutation in HLA B27 Positive Individuals Infected with HIV-1
P Ammaranond*1, D van Bockel1, J Zaunders2, C Satchell2, J Guerin1, D Cooper1, and A Kelleher1
1Natl. Ctr. in HIV Epidemiology and Clin. Res., Univ. of New South Wales, Sydney, Australia and 2St. Vincent’s Hosp., Sydney, Australia
225CD8+ T-cell Responses Directed against an Immunodominant HIV-1 Epitope Cross-restricted by HLA Alleles Associated with Different Effect on Disease Progression are Defined by Differential TCR Vbeta Usage
X G Yu*1, D Meyer-Olson1, M Lichterfeld1, B Perkins1, A Y Kim1, M Johnston1, M Parta2, A G Wurcel1, G Alter1, T Allen1, S A Kalams1, M M Addo1, B D Walker1, and M Altfeld1
1Partners AIDS Res. Ctr., Boston, MA, USA and 2AIDS Prgm., Bellevue Hosp. Ctr., New York, NY, USA
226
Differences in T-cell Responses against HIV Epitopes may Explain Associations of Certain HLA Class I Alleles with Disease Progression
S Sabbaj*1, A Bansal1, K Yusim2, R Kaslow1, J Tang1, M Mulligan1, B T Korber2, C Wilson1, and P Goepfert1
1Univ. of Alabama at Birmingham, USA and 2Los Alamos Natl. Lab., NM, USA