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Session 43   Poster Abstracts
Cellular Responses under HAART
Monday, 1:30 - 3:30 pm
Poster Hall
227Evidence for Thymic Function in HIV-infected Adults Following Sustained Suppression of Chronic HIV Infection
J-F Poulin*1, J M Harris1,2, D Higuera-Alhino1, M Gotway2, and J M McCune1,2
1Gladstone Inst. of Virology and Immunology, San Francisco, CA, USA and 2Univ. of California, San Francisco, USA
228Intensification of Antiretroviral Treatment in Subjects with Long-term Viral Suppression Does Not Lead to Substantial Improvement in Residual Immune Deficits or Significant Reduction in HIV-1 Latent Reservoir
K Y Smith*1, H Valdez2, E Aga3,4, R J Bosch3,4, E Connick5, P Clax6,7, J Rooney8, A Landay1, B Patterson9, R Siliciano10, M Lederman11, and for the ACTG a5136 Protocol Team
1Rush Univ. Med. Ctr., Chicago, IL, USA; 2Boehringer-Ingelheim Pharm., Ridgefield, CT, USA; 3Harvard Sch. of Publ. Hlth., Boston, MA, USA; 4Harvard Med. Sch., Boston, MA, USA; 5Univ. of Colorado Hlth. Sci. Ctr., Denver, USA; 6Abbott Labs., Chicago, IL, USA; 7; 8Gilead Sci., Inc., Foster City, CA, USA; 9Stanford Univ. Med. Ctr., CA, USA; 10Johns Hopkins Univ., Baltimore, MD, USA; and 11Case Western Reserve Univ., Cleveland, OH, USA
229Presence of Higher Numbers of HIV-specific Late Effector CD8+ T cells in Patients Partially Controlling Multi-drug Resistant Virus and in Long-term Non-progressors
B Emu*1, W J Moretto2, R Hoh1, J M McCune2, D F Nixon2, and S Deeks1
1Univ. of California, San Francisco, USA and 2Gladstone Inst. of Virology and Immunology, San Francisco, CA, USA
230
Quantitative CD38 Expression on CD8 T Cells as a Predictor of CD4 T-cell Maintenance among Patients Failing Salvage Antiretroviral Therapy
M Goicoechea*1, C Miller1, C Spina2, J Currier3, C Kemper4, M Witt5, J Leedom6, D Forthal7, P Keiser8, A McCutchan1, D Richman2, R Haubrich1, and California Collaborative Treatment Group (CCTG)
1Univ. of California, San Diego, USA; 2Univ. of California, San Diego, and VA Healthcare System, La Jolla, CA, USA; 3Univ. of California, Los Angeles, USA; 4Santa Clara Valley Med. Ctr., San Jose, CA, USA; 5Harbor-UCLA Med. Ctr., Univ. of California, Los Angeles, USA; 6Univ. of Southern California, Los Angeles, USA; 7Univ. of California, Irvine, USA; and 8Univ. of Texas, Dallas, USA
231 Efficacy of and Immunologic Responses to Influenza Vaccine in HIV-1-infected Patients: A Prospective Study
H Yamanaka*1, K Teruya1, M Tanaka1, M Honda1, H Gatanaga1, I Genka1, N Tachikawa1, Y Kikuchi1, Y Hirabayashi1, T Gotanda2, Y Suzuki2, S Kimura1, and S Oka1
1Intl. Med. Ctr. of Japan, Tokyo and 2Kitasato Inst. Res. Ctr. for Biologicals, Tokyo, Japan
232ACTG 5015: Naïve T-cell Reconstitution is Associated with Immune Activation
R Kalayjian*1, A Landay2, R Pollard3, M Pu4, J Spritzer4, P Tebas5, B Gross6, V Valcour7, S Cu-Uvin8, S Fiscus9, P Fidel10, A Wu11, L Fox12, V Stocker13, M Lederman14, and AIDS Clinical Trials Group Protocol 5015
1MetroHlth. Med Ctr, Cleveland, OH, USA; 2Rush-Presbyterian, Chicago, IL, USA; 3Univ. of California, Davis, USA; 4Harvard Sch. of Publ. Hlth., Boston, MA, USA; 5Univ. of Pennsylvania, Philadephia, USA; 6Univ. of Michigan, Ann Arbor, USA; 7Univ. of Hawaii, Honolulu, USA; 8Brown Univ. Med. Sch., Providence, RI, USA; 9Univ. of North Carolina at Chapel Hill, USA; 10Louisiana State Univ, New Orleans, LA, USA; 11Johns Hopkins Univ., Baltimore, MD, USA; 12DAIDS, NIAID, NIH, DHHS, Bethesda, MD, USA; 13AACTG Operations Ctr., Bethesda, MD, USA; and 14Case Western Reserve Univ., Cleveland, OH, USA
233Persistent Anti-HIV CD4+ T Cell Lymphoproliferative Responses Result in no Suppressive Effect on the Level of Viral Rebound after Treatment Interruption in Chronically HIV-1-infected "Blippers"
E Papasavvas*1, J Kostman2, M Pistilli1, B Thiel1, A Mackiewicz1, A Foulkes3, R Gross3, K Jordan4, J Sandberg4, D Nixon4, C Gallo5, J Ondercin5, L Schmidt5, K Mounzer5, and L Montaner1
1Wistar Inst., Philadelphia, PA, USA; 2Philadelphia Field Initiating Group for HIV-1 Trials and the Univ. of Pennsylvania, USA; 3Ctr. for Clin. Epidemiology and Biostatistics, Univ. of Pennsylvania, Philadelphia, USA; 4Gladstone Inst. of Virology and Immunology, Univ. of California, San Francisco, USA; and 5Philadelphia Field Initiating Group for HIV-1 Trials, PA, USA
234
Survey of HIV-specific Immune Responses in HAART-naive, HIV+ Subjects in the Chronic Phase of Infection
Y Peretz*1, G Alter2, G Makedonas1, C M Tsoukas1, and N F Bernard1
1McGill Univ., Montreal, Canada and 2Massachusetts Gen. Hosp., Boston, USA
235Suppression of HIV-1 Replication with Antiretroviral Therapy during Chronic Infection Is Associated with Broadening of HIV-1 p24-specific CD4+ T-cell Epitope Recognition
E Boritz*, B Palmer, and C C Wilson
Univ. of Colorado Hlth. Sci. Ctr., Denver, USA
236Viral Rebound after Discontinuing Antiretroviral Treatment is Influenced by HIV Nef-specific CD8+ T-cell Responses
M Lopez*, J M Benito, P Barreiro, and V Soriano
Hosp. Carlos III, Madrid, Spain
237T-cell Responses to HIV and Opportunistic Pathogens Following Patient Initiated Interruption of Antiretroviral Treatment
R Schrier*, S Letendre, D Durand, J A McCutchan, HIV Neurobehavioral Res Ctr, and R Ellis
Univ. of California, San Diego, USA
238Immunologic Determinants of Failure in Individualized Structured Treatment Interuptions. Should the Timing of HAART be Reconsidered?
F Maggiolo*1, D Ripamonti1, D Trabattoni2, G Quinzan1, G Gregis1, M Schenal2, M Clerici2, and F Suter1
1Hosp. Riuniti, Bergamo, Italy and 2Univ. Med. Sch., Milan, Italy
239
Restoration of CD4+ T-cell Responses to Cytomegalovirus is Short-lived in Severely Immunodeficient HIV Patients Responding to Highly Active Antiretroviral Therapy
M A French*, N M Keane, S F Stone, P Price, S Lee, C Almeida, and I James
Royal Perth Hosp., Australia
240
32-Week Period of Suppressive Antiretroviral Therapy Fails to Reconstitute Innate Immunity Parameters
L Azzoni*1, J Chehimi1, M Farabaugh1, C Herman2, K Mounzer2, J Kostman3, and L J Montaner1
1Wistar Inst., Philadelphia, USA; 2Jonathan Lax Clin. - FIGHT, Philadelphia, PA, USA; and 3Presbyterian Med. Ctr., Philadelphia, PA, USA
241
Differential Effect of HAART during Acute HIV infection on HIV-specific CD4+ T-cell Proliferative Capacity and Function
C Jansen*1, I De Cuyper1, R Steingrover2, S Jurriaans2, J Prins2, D van Baarle1, and F Miedema1
1Sanquin Res., Academic Med. Ctr., Univ. of Amsterdam, The Netherlands and 2Academic Med. Ctr. and Intl. Antiviral Therapy Ctr., Amsterdam, The Netherlands