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Session 54   Poster Abstracts
Virus Entry, Receptors, and Co-Receptors
Monday, 1:30 - 3:30 pm
Poster Hall
308Envelope-mediated Membrane Fusion of Patient HIV-1 Isolates Varies with Co-receptor Usage
W Huang*, S Fransen, J Toma, C J Petropoulos, and J M Whitcomb
ViroLogic Inc., South San Francisco, CA, USA
309Characterization of Membrane Dynamics and Virion Fusion
H Henderson*, and T J Hope
Univ. of Illinois at Chicago, USA
310Effect of Envelope Co-receptor Affinity on Fusion, Infection, and Entry Inhibitor Sensitivity
J Reeves*, J Miamidian, M Biscone, F-H Lee, N Ahmad, T Pierson, and R Doms
Univ. of Pennsylvania, Philadelphia, USA
311Identification of Small Molecule HIV-1 Fusion Inhibitors
K Salzwedel*, K Crisafi, T Jackson, A Castillo, N Kilgore, M Reddick, G Allaway, and C Wild
Panacos Pharm., Gaithersburg, MD, USA
312HIV-1 Infection Is Associated with Altered Phenotype and Function of DC-SIGN+ Dendritic Cells in the Human Gut Mucosa
K Gurney*, J Elliott, H Nassanian, C Song, I Mac Gowan, P Anton, and B Lee
Univ. of California, Los Angeles, Sch. of Med., USA
313HIV Recognition of both CCR5 and Syndecan Depends on 2 Highly Conserved Arginines in the V3 Loop of Gp120
M Bobardt1, A Parseval1, J Elder1, T-H Lee2, G David3, and P Gallay*1
1Scripps Res. Inst., La Jolla, CA, USA; 2Harvard Sch. of Publ. Hlth., Boston, MA, USA; and 3Ctr. for Human Genetics, Univ. of Leuven, Belgium
314Delineating DC-SIGN Binding to gp120, ICAM2, and ICAM3
S Su*, P Hong, and B Lee
Univ. of California, Los Angeles, USA
315Cellular and Molecular Requirements of DC-SIGN-mediated HIV-1 Transmission
V N KewalRamani*
NCI, NIH, DHHS, Frederick, MD, USA
316Fusion Differences between R5 and X4 HIV-1 in Dendritic Cells: Implications for Selective Transmission of R5 Strains
M Cavrois*, J A Neidleman, C Callebaut, J F Kreisberg, D Fenard, and W C Greene
Gladstone Inst. of Virology and Immunology, Univ. of California, San Francisco, USA
317R5 HIV-1 Strains Replicate More Efficiently in Primary CD4+ T Cell Cultures than X4 HIV-1 Strains
B Schweighardt*, D A Meiklejohn, E J Grace III, and D F Nixon
Gladstone Inst. of Virology and Immunology, Univ. of California, San Francisco, USA
318Preferential Utilization of CXCR4 in Primary Lymphocytes but not in Primary Macrophages by R5X4 Strains: Implication for Viral Tropism, Evolution and Pathogenesis
Y Yi*, D Laddy, and R Collman
Univ. of Pennsylvania, Philadelphia, USA
319Virus Transmission by Dendritic Cells in a Non-pathogenic Model of SIV Infection
M J Ploquin1, O M Diop2, N Sol-Foulon3, L Mortara1, A Faye2, A Amara4, O Schwartz3, F Barré-Sinoussi1, and M C Müller-Trutwin*1
1UBR, Inst. Pasteur, Paris, France; 2Inst. Pasteur, Dakar, Senegal; 3Inst. Pasteur, Paris, France; and 4UIV, Inst. Pasteur, Paris, France
320
Attachment Levels of HIV Differ between PBMC Donors in a CD4-independent Manner
J Anzinger*1, G Spear1, I Mezo1, and M Saifuddin2
1Rush Univ., Chicago, IL, USA and 2CONRAD Prgm., Arlington, VA, USA
321The N-Terminal Domain of APJ, a CNS-based Co-receptor for HIV-1, Is Essential for its Novel Receptor Function and Co-receptor Activity
N Zhou*, X Zhang, X Fan, E Argyris, J Fang, E Acheampong, G DuBois, and R Pomerantz
Thomas Jefferson Univ., Philadelphia, PA, USA
322
Host Range Extension of Avian Leukosis Virus Following Extensive Passage in Chick Embryo Fibroblasts
D Negusse*1, L Drew2, and J Coffin1
1Tufts Univ., Boston, MA, USA and 2Univ. of Bath, UK
323Effect of Sera from HIV-1-infected Individuals on HIV Envelope-dependent Cell-cell Fusion Is Related to the CD4+ Cell Counts, Viral Load, and Clinical Status
L Huerta1, G Gomez-Icazbalceta1, L Soto-Ramirez*2, M Viveros-Rogel2, R Rodriguez-Diaz2, L Fuentes-Romero2, E Lamoyi1, and C Larralde1
1Inst. de Investigaciones Biomedicas, UNAM, Mexico City, MEXICO and 2Natl. Inst. of Med. Sci. and Nutrition, Mexico City, Mexico