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Session 57   Poster Abstracts
Viral Replication: Positive and Negative Host Co-Factors
Wednesday, 1:30 - 3:30 pm
Poster Hall
351APOBEC3G: A Potent Viral DNA Mutator from the Host
H Zhang*, B Yang, R J Pomerantz, K Chen, S C Arunachalam, C Zhang, and L Gao
Thomas Jefferson Univ., Philadelphia, PA, USA
352Species-specific Target Specificity of APOBEC3G
M Kobayashi*, A Takaori-Kondo, K Shindo, A Abudu, A Sasada, and T Uchiyama
Kyoto Univ. Sch. of Med., Japan
353A Single Amino Acid Change Controls the Ability of HIV-1 Vif to Discriminate Between Human and African Green Monkey APOBEC3G
B Doehle*1, H Bogerd1,2, H Wiegand1,2, and B Cullen1,2
1Duke Univ., Durham, NC, USA and 2Howard Hughes Med. Inst.
354Biophysical and Structural Analysis of HIV-1 Vif and its Cellular Inhibitor APOBEC3G
J Auclair*, M Somasundaran, and C Schiffer
Univ. of Massachusetts Med. Sch., Worcester, USA
355The Sequence of Proviruses Resulting from Vif-defective HIV-1 Infection Supports Direct APOBEC3G Deamination of Minus-strand DNA during Reverse Transcription
F Bouchonnet, D Lecossier, F Clavel, and A J Hance*
INSERM U552, Paris, France
356Mapping the Restriction Determinants in HIV-1 Capsid and Defining the Role of Cyclophilin A in Restriction
T Hatziioannou*, S Cowan, and P D Bieniasz
Aaron Diamond AIDS Res. Ctr., New York, NY, USA
357Natural Resistance of HIV-1 Primary Isolates to Ref1
M Bobardt, A Saphire, and P Gallay*
Scripps Res. Inst., La Jolla, CA, USA
358ARF-1 Independent Attachment of AP Complexes to Endosomal Membranes by HIV-1 Nef Correlates with Virologic Function
J Guatelli*1,2, D Hitchin1, C Noviello2, S Coleman2, R Madrid3, and S Benichou3
1San Diego VA Healthcare System, CA, USA; 2Univ. of California, San Diego, USA; and 3Inst. Cochin, INSERM, Paris, France
359
Polymorphisms in Cellular Restriction of HIV-1 Infection
A Ciuffi*1, G Bleiber1, M Munoz1, R Martinez1, P Meylan1, S Bonhoeffer2, D Trono3, and A Telenti1
1Univ. of Lausanne, Switzerland; 2Univ. of Zurich, Switzerland; and 3Univ. of Geneva, Switzerland
360Inhibition of HIV-1 Replication by a Novel Domain of Sam68, the 68-Kilodalton Src-associated Protein In Mitosis
J Zhang*1,2, Y Liu1,2, J Li1,2, and J J He1,2
1Indiana Univ. Sch. of Med., Indianapolis, USA and 2Walther Cancer Inst., Indianapolis, IN, USA
361A DEAD Box Protein Facilitates HIV-1 Replication as a Critical Cellular Co-factor of Rev
R Pomerantz*1, J Fang1, S Kubota1, B Yan1, N Zhou1, H Zhang1, and R Godbout2
1Thomas Jefferson Univ., Philadelphia, PA, USA and 2Univ. of Alberta, Canada
362INI/hSNF5 Mediates Specific Incorporation of Components of Sin3A-HDAC Complex into HIV-1 Virions
M Sorin*, K Davies, SWG Cheng, and G V Kalpana
Albert Einstein Coll. of Med., Bronx, NY, USA
363Changes in the Ratio of P-TEFb Complexes Correlates with a Reduction in HIV Replication
S Biglione*, S Byers, D Shutt, D Price, and W Maury
Univ. of Iowa, Iowa City, USA
364Small Heat Shock Proteins as Innate Antiviral Factors Counteracted by HIV-1 Viral Protein R
Y Zhao*1, Z Benko1, D Liang1, J Hou1, K Chiu1, E Agbottah2, M Yu1, S Innis1, P Reed1, W Kabat1, R T Elder1, P Di Zarzio2, L Taricani3, P G Young3, and M Bukrinsky2
1Northwestern Univ., Chicago, IL, USA; 2George Washington Univ., Washington, DC, USA; and 3Queen's Univ., Kingston, Ontario, Canada
365
Role of SHP-1 Deregulation in HTLV-1 Leukemogenesis
J Cheng*, A Kydd, K Noonan, C Xu, A Murakami, and W Marasco
Dana-Farber Cancer Inst., Boston, MA, USA
366Niemann Pick Type C: an Important Protein during HIV Infection
I Carneiro Leao*, and J E K Hildreth
Johns Hopkins Sch. of Med., Baltimore, MD
367
alpha-Defensin-1 Inhibits HIV-1 following Entry and Involves PKC Signaling Pathway
T L Chang, J Vargas Jr, A Lukay, and M E Klotman*
Mount Sinai Sch. of Med., New York, NY, USA