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Session 60   Poster Abstracts
Primary Infection: Viral Pathogenesis
Tuesday, 1:30 - 3:30 pm
Poster Hall
384env Sequences and Neutralization of HIV from Transmission Partners of Primary HIV Infection
S J Little*1, Y Liu2, T Wrin2, S D W Frost1, C Chappey2, D M Smith1, C J Petropoulos2, and D D Richman1,3
1Univ. of California, San Diego, USA; 2ViroLogic Inc., South San Francisco, CA, USA; and 3San Diego VA Healthcare System, CA, USA
385
Primary HIV-1 Infection is Clonal in a Minority of Women from Africa
M Sagar*1,2, E Kirkegaard2, L Lavreys2,3, and J Overbaugh1
1Fred Hutchinson Cancer Res. Ctr., Seattle, WA, USA; 2Univ. of Washington, Seattle, USA; and 3Univ. of Nairobi, Kenya
386HIV-1 V1/V2 and V3 env Diversity during Primary Infection Suggests a Role for Multiply Infected Cells in Transmission
K Ritola*1, C Pilcher1, S Little2, S Fiscus1, C Hicks3, J Eron1, D Richman2, and R Swanstrom1
1Univ. of North Carolina at Chapel Hill, USA; 2Univ. of California, San Diego, USA; and 3Duke Univ., Durham, NC, USA
387Consistent Recovery of Fully Infectious HIV-1 from Infected Seronegative Children Receiving Combination Antiretroviral Therapy from Early Infancy.
D Persaud*1, J Kajdas1, D Watson2, and R Siliciano1
1Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA and 2Univ. of Maryland Sch. of Med., Baltimore, USA
388
Higher CD4+ T Cell Counts Associated with Low Viral pro/pol Replication Capacity among Treatment Naïve Adults in Early HIV-1 Infection
J D Barbour*1,2, M R Segal2, T Wrin3, C A Ramstead2, T J Liegler1, C J Petropoulos3, F M Hecht2, and R M Grant1,2
1Gladstone Inst. of Virology and Immunology, San Francisco, CA, USA; 2Univ. of California, San Francisco, USA; and 3ViroLogic Inc., South San Francisco, CA, USA
389Intermittent Low-Level Viremia During the Eclipse Phase of Primary HIV-1 Infection.
E W Fiebig*1,2, C Heldebrant3, R Smith3, A Conrad3, E L Delwart1,4, and M P Busch1,4,5
1Univ. of California, San Francisco, USA; 2San Francisco Gen. Hosp., CA, USA; 3Natl. Genetics Inst., Los Angeles, CA, USA; 4Blood Ctrs. of the Pacific, San Francisco, CA, USA; and 5Blood Systems Inc., Scottsdale, AZ, USA
390Oral Transmission of SIV Indicates Entry across the Oral and Esophageal Mucosa Followed by Rapid Dissemination
J Milush*1, D Kosub1, K Schmidt2, F Scott1, C Brown3, S Westmoreland4, M Marthas2, and D Sodora1
1Univ. of Texas Southwestern Med. Ctr., Dallas, USA; 2Univ. of California, Davis, USA; 3NIAID, NIH, DHHS, Rockville, MD, USA; and 4New England Primate Res. Ctr., Harvard Med. Sch., Southborough, MA, USA
391
Phylogenetic Relationships between HIV-1 Viruses from Seroconverters across Europe
R Gifford*1, P Cane2, N Back3, H Fleury4, C Nielsen5, M Ortiz6, C Balotta7, K Porter8, D Pillay1, and CASCADE Virology Collaboration
1Univ. Coll. London, UK; 2HPA, Univ. Birmingham, UK; 3Academic Med. Ctr., Amsterdam, The Netherlands; 4Hosp. Pelligrin, Bordeaux, France; 5SSI, Copenhagan, Denmark; 6ISC II, Madrid, Spain; 7IITD, Milan, Italy; and 8MRC CTU, London, UK
392
Molecular and Epidemiological Characteristics of Primary HIV-1 Infections among a Cohort of Predominantly Men Who Have Sex with Men in a Defined Geographical Area: Transmission Events Associated with High Risk Activity and STD
D Pao*1, M Fisher1, S Hué2, G Dean1, P Cane3, C Sabin4, and D Pillay2
1Brighton and Sussex Univ. Hospitals, UK; 2Univ. Coll. London, UK; 3Univ. of Birmingham Med. Sch., UK; and 4Royal Free and Univ. Coll. Med. Sch., London, UK
392bIntestinal Pathogenesis during Primary HIV-1 Infection and Comparison with the SIV Model
M D George*1, M Guadalupe1, S Sankaran1, T Prindiville1, J Flamm2, and S Dandekar1
1Univ. of California, Davis, USA and 2Kaiser Permanente, Sacramento, CA, USA