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Session 7
Oral Abstracts Immune Responses to HIV Monday, 10 am - 12:30 pm Room 2005 |
| Moderators | John Zaunders St Vincent's Hosp, Sydney, Australia Amitinder Kaur New England Primate Res Ctr, Harvard Med Sch, Southborough, MA, USA |
| 10:00 am 10 | Gag-specific T Helper and CTL Responses Are Associated with Effective Control of HIV C Clade Infection in Durban, South Africa
D Ramduth*1, P Chetty1, N Ntumba1, S Gappoo1, J Harlow1, C Henry1, I Honeyborne1, P Jeena1, M M Addo2, M Altfeld2, C Brander2, P Kiepiela1, B D Walker2,3, and P J R Goulder4 1Univ. of Natal, Durban, South Africa; 2Partners AIDS Res. Ctr., Massachusetts Gen. Hosp., Boston, USA; 3Howard Hughes Med. Inst. and Harvard Med. Sch., Cambridge, MA, USA; and 4Nuffield Dept. of Med., Pathogen Res., Oxford, UK |
| 10:15 am 11 | Immunological and Genetic Determinants in HIV-1 Controllers and Long-term Non-progressors M M Addo*1, A Rathod1, R Draenert1, D Kaufmann1, M R Perkins1, C Verrill1, M N Johnston1, A G Wurcel1, C Corcoran1, J Braun2, M Altfeld1, S K Kalams3, S Buchbinder4, E S Rosenberg1, B D Walker1, and The HIV-1 controller study group 1Partners AIDS Res. Ctr., Massachusetts Gen. Hosp., Boston, USA; 2Physicians Res. Network, New York, NY, USA; 3Vanderbilt Univ. Med. Ctr., Nashville, TN, USA; and 4San Francisco Dept. of Publ. Hlth., CA, USA |
| 10:30 am 12 | Comparison of CD8 T-Cell Responses and Viral Escape in HIV-infected Monozygotic Twins R Draenert*1, T M Allen1, G Sirera2, C L Verrill1, R Eldridge1, L Ruiz2, B D Walker1, and J Martinez-Picado2 1Partners AIDS Res. Ctr., Boston, MA, USA and 2Fndn. IrsiCaixa, Barcelona, Spain |
| 10:45 am 13 | Selection, Transmission, and Reversion of an Antigen Processing CTL Escape Mutation in HIV-1
T M Allen*1, M Altfeld1, X G Yu1, K M O'Sullivan1, M Lichterfeld1, P K Lee1, S Le Gall1, B R Mothe2, D E Cohen3, K A Freedberg1, A Sette4, E S Rosenberg1, P J R Goulder5, C Brander1, and B D Walker1 1Partners AIDS Res. Ctr., Massachusetts Gen. Hosp., Harvard Med. Sch., Boston, USA; 2Epimmune, San Diego, CA, USA; 3Fenway Community Hlth. Ctr., Boston, MA, USA; 4La Jolla Inst. of Allergy and Immunology, San Diego, CA, USA; and 5Nuffield Dept. of Med., Pathogen Res., Oxford, UK |
| 11:00 am 14 | CD4+CD25+ Regulatory T-like Cells Suppress HIV-specific CD4+ and CD8+ T Cell Immune Responses in vitro A Kinter*1, M Hennessey1, A Bell1, Y Lin1, R Jackson1, M Planta1, M McLaughlin1, S Zeigler2, and A S Fauci1 1NIH, DHHS, Bethesda, MD, USA and 2Virginia Mason, Seattle, WA, USA |
| 11:15 am 15 | Functional and Phenotypic Heterogeneity of Memory CD4 T Cells Are Dictated by Antigen Persistence and Load A Harari*, F Vallelian, S C Zimmerli, and G Pantaleo Lab. of AIDS Immunopathogenesis, Lausanne, Switzerland |
| 11:30 am 16 | Substantial discrepancies between cytotoxic activity and interferon- M Lichterfeld*, X G Yu, D Kaufmann, S Mui, N Johnston, D Cohen, M M Addo, D Strick, E S Rosenberg, B D Walker, and M Altfeld Massachusetts Gen. Hosp., Harvard Med. Sch., Boston, MA, USA |
| 11:45 am 17 | Infection with HIV-1 Leads to Up-regulation of HLA-E Expression Resulting in Impaired Cytotoxic Function of Natural Killer Cells J Nattermann*1, H D Nischalke1, V Hofmeister2, B Kupfer1, G Ahlenstiel1, G Feldmann1, J Rockstroh1, E Weiß2, T Sauerbruch1, U Spengler1, and BMBF, Kompetenznetz HIV/AIDS 1Univ. of Bonn, Germany; 1Univ. of Bonn, Germany; and 2Ludwig-Maximilians-Univ., Munich, Germany |
| 12:00 pm 18 | Stoichiometry of neutralization of HIV-1 primary isolate JR-CSF by anti-gp120 antibodies M Franti*1, S Frost2, M Guyader1, K Delgado1, D R Burton1, and P Poignard1 1Scripps Res. Inst., La Jolla, CA, USA and 2Univ. of California, San Diego, USA |
| 12:15 pm 19 | Neutralizing Antibody Responses Often Persist at High Titers in Chronic HIV Infection but Do Not Exert an Antiviral Effect Against Autologous Virus S Deeks*1, T Wrin2, J Galovich2, J Martin1, and C Petropoulos2 1Univ. of California, San Francisco, USA and 2ViroLogic Inc., South San Francisco, CA, USA |