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Session 76   Poster Abstracts
General and Virus-Specific Immune Augmentation Strategies
Tuesday, 1:30 - 3:30 pm
Poster Hall
509
Beneficial Effects of IL-2 and GM-CSF Immunotherapy in Immune Restoration Disease and on HIV-1-Specific T-Cell Responses after Antiretroviral Therapy
N Imami*1, A Pires1, M Nelson2, A Pozniak2, M Fisher2, B Gazzard2, and F Gotch1
1Imperial Coll., London, UK and 2Chelsea and Westminster Hosp., London, UK
510Interleukin-2 Prior to Stopping Effective Antiretroviral TherapyProlongs Time Off Treatment: Initial Results of a Pilot Study Utilizing CD4++ T-cell Count <350 cells/mm3 as the Threshold for Restarting ART (ACTG A5102)
K Henry*1,2, P Tebas3, D Cherng4, J Schmitz5, D Katzenstein6, H Valdez7, N Jahen8, M Vargas8, L Myers9, D Sahner10, W Powderly11, and the Adult AIDS Clinical Trials Group and A5102 Team
1Univ. of Minnesota, Minneapolis, USA; 2Hennepin County Med. Ctr., Minneapolis, MN, USA; 3Univ. of Pennsylvania, Philadelphia, USA; 4Harvard Sch. of Publ. Hlth., Boston, MA, USA; 5Univ. of North Carolina at Chapel Hill, USA; 6Stanford Univ., Palo Alto, CA; 7Case Western Reserve Univ., Cleveland, OH, USA; 8AACTG Operations Ctr., Silver Spring, MD, USA; 9Frontier Sci. and Technology Res. Fndn., Amherst, NY, USA; 10Chiron Corp., Emeryville, CA, USA; and 11Washington Univ., St. Louis, MO, USA
511
IL-7/IL-7 Receptor System Regulation Following IL-2 Immunotherapy in HIV-infected Patients
G Marchetti*1, L Meroni1, C Molteni1, G Taskaris1, L Gazzola1, M Galli1, M Clerici2, M Moroni1, F Franzetti1, and A Gori1
1Inst. of Infectious Diseases and Tropical Med., Univ. of Milan, Italy and 2Univ. of Milan, Italy
512IL-15 Treatment of SIV-infected Non-human Primates
C Petrovas*1, Y M Mueller1, P Bojczuk1, I D Dimitriou1, B Beer2, P Silvera2, F Villinger3, J S Cairns4, M G Lewis5, and P D Katsikis1
1Drexel Univ. Coll. of Med., Philadelphia, PA, USA; 2Southern Res. Inst., Frederick, MD, USA; 3Emory Univ., Atlanta, GA, USA; 4Henry M. Jackson Fndn., Bethesda, MD, USA; and 5Bioqual, Inc., Rockville, MD, USA
513
Filgrastim Stimulates HIV-1 Replication in Monocytoid Cells
R Rapaport*, C McLean, and T B Campbell
Univ. of Colorado Hlth. Sci. Ctr., Denver, USA
514Cyclooxygenase-2 Inhibitors Induce T Cell Subset Changes in Patients on Highly Active Antiretroviral Treatment and with Persistent Viremia
D Kvale*1, V Ormaasen1, A-M Kran1, S Frøland2, and K Taskén3
1Ullevål Univ. Hosp., Oslo, Norway; 2Rikshospitalet, Oslo, Norway; and 3Univ. of Oslo and Lauras AS, Norway
515Long-term Evolution without Antiretroviral Therapy of Chronic HIV-1-infected Patients with Good Virological Response to Cycles of Structured Treatment Interruption
E Florence, F Garcia, M Plana, E Fumero*, P Castro, A Cruceta, C Gil, M Arnedo, T Pumarola, T Gallart, and J M Gatell
Hosp. Clin.-IDIBAPS, Barcelona Univ., Spain
516Gene Therapy of HIV Infection by Transduced Autologous CD4+ T Cells Inhibiting Viral Entry
J van Lunzen*1, G Brandenburg2, C Baum3, K Kuehlcke4, G Koopman5, A Alexandrov6, I Stahmer1, H-J Stellbrink1, and D von Laer2
1Univ. Hosp. of Eppendorf, Hamburg, Germany; 2Georg-Speyer-Inst., Frankfurt, Germany; 3Univ. of Hannover, Germany; 4EUFETS AG, Idar-Oberstein, Germany; 5BPMRC Rijswijk, Netherlands; and 6Fresenius HemoCare, Martinsried, Germany
517HIV-Blocking Fully Human Antibodies against CCR5 Generated by 2-Hybrid System
S B Hua*1, M Pauling1, D Erichsen2, Y H Lin1, A Tran1, J Zheng2, and L Zhu1
1Genetastix Corp., San Jose, CA, USA and 2Univ. of Nebraska Med. Ctr., Omaha, USA
518
Final Results of A Phase I Study of a Therapeutic Vaccine Using Autologous Dendritic Cells Primed with Autologous Virus in Patients with Chronic HIV Infection and CD4 T Cells above 400/Mm3
F Garcia1, M Lejeune1, N Climent1, C Gil1, J Alcami2, V Morente1, L l Alós1, E Florence1, A Libois1, A Pereira1, J M Miro1, T Pumarola1, M Plana1, J M Gatell*1, and T Gallart1
1Hosp. Clin.-IDIBAPS, Barcelona Univ., Spain and 2Inst. Carlos III, Madrid.
519
Analysis of Nef-specific T-cells, Viral Rebound and Autologous Viral Sequences during Structured Treatment Interruption after Therapeutic Vaccination with a MVA-BN-Nef Vaccine in HIV-1-infected Patients on HAART
E Harrer1, M Bauerle1, B Ferstl1, P Chaplin2, B Petzold2, S Bergmann1, M Hamacher1, K Eismann1, J R Kalden1, and T Harrer*1
1Univ. Hosp. Erlangen, Germany and 2Bavarian-Nordic, Martinsried, Germany
520
Use of Solvent Treated SIV to Induce/Augment SIV-specific CD4+ and CD8+ T Cell Memory Responses in Mice: A Model for a New Therapeutic Vaccination Strategy against HIV Infection
A Ansari1, F Villinger1, J E K Hildreth*2, A Mayne1, and J B Maltais3
1Emory Univ. Sch. of Med., Atlanta, GA, USA; 2Johns Hopkins Sch of Med, Baltimore, MD, USA; and 3Lipid Sci., Inc., Pleasanton, CA, USA
521
BAY 50-4798, an IL-2 Selective Agonist, Is Associated with Lower Levels of Cytokine Production than Aldesleukin
S Steppan*, M Eckart, J Greve, and D Cassell
Biotechnology Res., Bayer Corp., Berkeley, CA, USA
522
Human Pharmacokinetic Evaluation of the IL-4/13 Trap: a Novel Immunomodulatory Agent for the Treatment of HIV Disease
M Parsey, G Fauci, J Dunn, C Marks, E Skop, N Stahl, and E Furfine*
Regeneron Pharm., Tarrytown, NY, USA
523Dynamics of T Cells Homeostasis Induced by Tucaresol
L Gazzola1, G Marchetti*1, A Bandera1, D Trabattoni2, C Molteni1, L Meroni1, D Thorborn3, R Panebianco4, M Moroni1, F Franzetti1, D Bray5, M Clerici2, and A Gori1
1Inst. of Infectious Diseases and Tropical Med., Univ. of Milan, Italy; 2Univ. of Milan, Italy; 3GlaxoSmithKline, Greenford, UK; 4GlaxoSmithKline, Verona, Italy; and 5Royal Free Coll., London, UK
524
Immediate Immunity against HIV Infection and Adjuvant Activity of gamma delta T Lymphocytes by Aminobiphosphonate plus IL-2 Administration
F Poccia*, R Casetti, A Martino, G D'Offizi, D Horejsh, and F Martini
Natl. Inst. for Infectious Diseases "L.Spallanzani", Rome, Italy