Home Search Abstracts Browse Sessions Program Committee Conference Webcasts Contact Us


Session 78   Poster Abstracts
New Antiretroviral Agents: Entry Inhibitors
Wednesday, 1:30 - 3:30 pm
Poster Hall
534Characterization of a Small Molecule HIV-1 Attachment Inhibitor BMS-488043: Virology, Resistance and Mechanism of Action
P F Lin*, H T Ho, Y F Gong, I Dicker, N Zhou, L Fan, B McAuliffe, B Kimmel, B Nowicka-Sans, T Wang, J Kadow, G Yamanaka, Z Lin, N Meanwell, and R Colonno
Bristol-Myers Squibb Co., Wallingford, CT, USA
535Safety, Tolerability, and Pharmacokinetics of a Novel, Small-Molecule HIV-1 Attachment Inhibitor, BMS-488043, after Single and Multiple Oral Doses in Healthy Subjects
G Hanna, J-H Yan*, W Fiske, T Masterson, D Zhang, and D Grasela
Bristol-Myers Squibb Co., Princeton, NJ, USA
536Phase 1b Study of the Anti-CD4 Monoclonal Antibody TNX-355 in HIV-1-infected Subjects: Safety and Antiretroviral Activity of Multiple Doses
J M Jacobson*1, D R Kuritzkes2, E Godofsky3, E DeJesus4, S Lewis5, J Jackson6, K Frazier6, E A Fagan6, and W R Shanahan6
1Beth Israel Med. Ctr., New York, NY, USA; 2Brigham and Women's Hosp., Boston, MA, USA; 3Bach & Godofsky, Bradenton, FL, USA; 4IDC Res. Initiative, Altamonte Springs, FL, USA; 5Univ. of Texas Hlth. Sci. Ctr., Houston, USA; and 6Tanox, Inc., Houston, TX, USA
537Control of HIV-1 Replication in the hu-PBL-SCID Mouse Model by an Anti-CCR5 Monoclonal Antibody
M Franti*1, L Ramos1, S Maloveste1, D Geerdes1, K A Nagashima2, T J Ketas3, K Delgado1, P J Maddon2, W C Olson2, and P Poignard1
1Scripps Res. Inst., La Jolla, CA, USA; 2Progenics Pharm., Tarrytown, NY, USA; and 3Weill Med. Coll. of Cornell Univ., New York, NY, USA
538Reversible Predominance of CXCR4 Utilising Variants in a Non-Responsive Dual Tropic Patient Receiving the CCR5 Antagonist UK-427,857
M Westby*1, J Whitcomb2, W Huang2, I James1, S Abel1, C Petropoulos2, M Perros1, and E van der Ryst1
1Pfizer Global Res. and Devt., Sandwich, UK and 2ViroLogic Inc., South San Francisco, CA, USA
539in vitro Anti-HIV Activity Profile of AMD887, a Novel CCR5 Antagonist, in Combination with the CXCR4 Inhibitor AMD070
D Schols*1, K Vermeire1, S Hatse1, K Princen1, E De Clercq1, G Calandra2, S Fricker2, K Nelson2, J Labrecque2, D Bogucki2, Y Zhou2, R Skerlj2, and G Bridger2
1Rega Inst. for Med. Res., Leuven, Belgium and 2AnorMED Inc., Langley, Canada
540
Determination of Binding Sites of a Unique CCR5 Inhibitor AK602 on Human CCR5
K Maeda*1, H Ogata1, S Harada1, Y Tojo1, T Miyakawa1, H Nakata1, Y Takaoka2, S Shibayama2, K Sagawa2, F Daikichi2, J Moravek3, E Arnold4, and H Mitsuya1,5
1Kumamoto Univ. Sch. of Med., Japan; 2ONO Pharm. Co. Ltd., Osaka, Japan; 3Moravek Biochemicals, Inc., Brea, CA; 4Rutgers Univ., Piscataway, NJ, USA; and 5NCI, NIH, DHHS, Bethesda, MD, USA
541
KRH-2731: An Orally Bioavailable CXCR4 Antagonist Is a Potent Inhibitor of HIV-1 Infection
T Murakami*1, A Yoshida1, R Tanaka1, S Mitsuhashi2, K Hirose2, M Yanaka2, N Yamamoto3, and Y Tanaka1
1Univ. of the Ryukyus, Okinawa, Japan; 2Kureha Chemical Industry Co. Ltd., Tokyo, Japan; and 3Tokyo Med. and Dental Univ., Japan