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Session 84   Poster Abstracts
New Insights into Intracellular and Plasma Pharmacokinetics of Antiretrovirals
Tuesday, 1:30 - 2:30 pm
Poster Hall

597
Lack of Evidence for the in vivo Transformation of ZDV-TP to d4T-TP in HIV-infected Subjects
M Melendez*1, R Blanco1, O Rosario1, W Delgado1, R Garcia1, J Santana1, H Garcia2, and J F Rodriguez1
1Univ. of Puerto Rico, USA and 2CLETS, PR Dept. of Hlth.
598Cellular Efflux is a Determinant of the Accumulation and Kinetics of Intracellular ZidovudineTriphosphate
J Rodman*1, B Robbins1, E Forbes1, S Fernandes1, Z Zhou2, and Pediatric AIDS Clinical Trials Group (PACTG)
1St. Jude Children's Res. Hosp., Memphis, TN, USA and 2Univ. of Southern California, Los Angeles, USA
599Intracellular SPD754 Triphosphate Pharmacokinetics following Administration of SPD754 Capsules
J Adams*1, J Sawyer2, and L Shiveley3
1PharmaRes., Morrisville, NC, USA; 2Prism Ideas Ltd., Nantwich, UK; and 3Shire Pharm. Inc., Rockville, MD, USA
600
Tenofovir Pharmacokinetics in Hepatic Impairment and Drug Interaction Potential with Agents Used to Treat Viral Hepatitis
B P Kearney*1, Y Benhamou1,2, J Flaherty1, J Sayre1, K Yale1, G Currie1, J Shah, and A Cheng
1Gilead Sci., Inc., Foster City, CA, USA and 2Group Hosp. Pitie-Salpetriere, Paris, France
601
Intracellular and Plasma Pharmacokinetics of Saquinavir/Ritonavir Administered Once Daily in HIV Infected Patients
J Ford*1, M Boffito2, A Wildfire2, A Hill3, D Back1, S Khoo1, M Nelson2, G Moyle2, B Gazzard2, and A Pozniak2
1Univ. of Liverpool, UK; 2Chelsea and Westminster Hosp., London, UK; and 3Roche, Welwyn, UK