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Session 85   Poster Abstracts
Pharmacology of Reverse Transcriptase Inhibitors
Tuesday, 1:30 - 3:30 pm
Poster Hall
602
Stavudine Extended Release Formulation and Tenofovir Disoproxil Fumarate: Lack of a Pharmacokinetic Drug Interaction
S Kaul*1, K Bassi1, B Damle1, J Xie1, J Gale1, E O'Mara1, B Kearney2, and K Ryan3
1Bristol-Myers Squibb Pharm. Res. Inst., Princeton, NJ, USA; 2Gilead Sci., Inc., Foster City, CA, USA; and 3Bristol-Myers Squibb Virology Med. Affairs, Plainsboro, NJ, USA
603
Efavirenz Is a Significant Inducer of Simvastatin and Atorvastatin Metabolism: Results of ACTG A5108 Study
J G Gerber*1, C J Fichtenbaum2, S Rosenkranz3, J M Vega4, A Yang4, B Alston5, SW Brobst6, Y Segal3, J A Aberg7, and The ACTG A5108 team
1Univ. of Colorado Hlth. Sci. Ctr., Denver, USA; 2Univ. of Cincinnati, OH, USA; 3Statistical and Data Analysis Ctr. (SDAC), Harvard Sch. of Publ. Hlth., Boston, MA, USA; 4Merck & Co, Inc., West Point, PA, USA; 5NIAID, NIH, DHHS, Bethesda, MD, USA; 6Social and Sci. Systems, Inc., Silver Spring, MD, USA; and 7Washington Univ., St. Louis, MO, USA
604
Sex and Weight as Covariates in the Pharmacokinetics of Efavirenz, Indinavir, and Nelfinavir
J Hitti*1, S Rosenkranz2, S Cohn3, L Kamemoto4, A Kashuba5, E Caten2, and F Aweeka6
1Univ. of Washington, Seattle, USA; 2Harvard Sch. of Publ. Hlth., Boston, MA, USA; 3Univ. of Rochester, NY, USA; 4Univ. of Hawaii, Honolulu, USA; 5Univ. of North Carolina at Chapel Hill, USA; and 6Univ. of California, San Francisco, USA
605Prevalence of Single Nucleotide Polymorphisms in MDR-1 and CYP3A Genes within a Heterogenous HIV-1-infected Population and Effect on Nevirapine Plasma Levels
M van der Ende*1, C Sahtoe1, J Dieleman1, D Burger2, and R van Schaik1
1Erasmus Med. Ctr., Rotterdam, The Netherlands and 2Univ. Med. Ctr. St. Radbout, Nijmegen, The Netherlands