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Session 86   Poster Abstracts
Pharmacology of Protease Inhibitors
Tuesday, 1:30 - 3:30 pm
Poster Hall
606Atazanavir Plasma Levels Associated with Efficacy and Safety in Protease Inhibitor-experienced HIV-infected Patients
A Barrios*, A Rendón, P Ríos, L Martín-Carbonero, D González de Requena, O Gallego, L Valer, I Maida, I Jimenez-Nacher, J Gonzalez-Lahoz, and V Soriano
Hosp. Carlos III, Madrid, Spain
607Atazanavir Enhances Saquinavir Hard Gel Concentrations in a Ritonavir-Boosted Once Daily Regimen.
M Boffito*1, M Kurowski2, G Kruse2, A Hill3, M Nelson1, G Moyle1, A Benzie1, C Higgs1, C Fletcher1, I Hitchcock4, B Gazzard1, and A Pozniak1
1Chelsea and Westminster Hosp., London, UK; 2Therapia GmbH, Berlin, Germany; 3Roche, Welwyn, UK; and 4Bristol-Myers Squibb Co., London, UK
608Steady State Pharmacokinetics of Saquinavir Hard Gel/Fosamprenavir 1000/700 plus 100 mg and 200 mg of Ritonavir Twice Daily in HIV+ Patients
M Boffito*1, L Dickinson2, A Hill3, M Nelson1, G Moyle1, C Higgs1, C Fletcher1, S Mandalia1, D Back2, B Gazzard1, and A Pozniak1
1Chelsea and Westminster Hosp., London, UK; 2Univ. of Liverpool, UK; and 3Roche, Welwyn, UK
609
Pharmacologic Management of the Drug-Drug Interaction between Lopinavir/Ritonavir and Amprenavir
H E Wynn Vezina*1, R C Brundage1, L Bushman2, and C V Fletcher2
1Univ. of Minnesota, Minneapolis, USA and 2Univ. of Colorado Hlth. Sci. Ctr., Denver, USA
610Predictive Power of Genotypic Inhibitory Quotient and Lopinavir Plasma Levels in both Efficacy and Lipid Elevations of LPV/r -based Salvage Regimens at 48 Weeks
D González de Requena*, T García-Benayas, O Gallego, F Blanco, L Valer, I Jimenez-Nacher, A L Rendón, and V Soriano
Hosp. Carlos III, Inst. de Salud Carlos III, Madrid, Spain
611Dose Separation Strategies to Overcome the Pharmacokinetic Interaction of a Triple Protease Inhibitor Regimen Containing Fosamprenavir Lopinavir, and Ritonavir
A H Corbett*1, L Davidson1, J J Park1, K Patterson1, J J Eron1, L Ngo1, M L Lim2, M Shelton2, M B Wire2, and A D M Kashuba1
1Chapel Hill, NC, USA and 2Res. Triangle Park, NC, USA
612
The PharmacokineticInteraction between GW433908 and Lopinavir/Ritonavir (APV10011 and APV10012)
M B Wire*1, O J Naderer1, A L Masterman2, Y Lou1, and D S Stein1
1GlaxoSmithKline, Research Triangle Park, NC, USA and 2GlaxoSmithKline, Montreal, Quebec, Canada
613Relationship between Lopinavir Concentration and Changes in Lipid Levels at 24 Weeks
B Best*1, S May1, M Witt2, C Kemper3, R Larsen4, C Diamond5, P Heseltine6, F He1, E Capparelli1, A McCutchan1, R Haubrich1, and the California Collaborative Treatment Group (CCTG)
1Univ. of California, San Diego, USA; 2Harbor-UCLA Med. Ctr., Univ. of California, Los Angeles Sch. of Med., Torrance, CA, USA; 3Santa Clara Valley Med. Ctr., San Jose, CA, USA; 4Univ. of Southern California, Los Angeles, USA; 5Univ. of California, Irvine, USA; and 6Quest Diagnostics, San Juan Capistrano, CA, USA
614
3-Way Pharmacokinetic Interaction among Amprenavir, Efavirenz, and a Second Protease Inhibitor
G D Morse*1, S Rosenkranz2, M F Para3, E Adams4, K E Yarasheski5, R C Reichman6, and Adult AIDS Clinical Trials Group (AACTG); DAIDS, NIAID, NIH; Bethesda, MD, USA
1State Univ. of New York at Buffalo, USA; 2Harvard Sch. of Publ. Hlth., Boston, MA, USA; 3Ohio State Univ., Columbus USA; 4DAIDS, NIAID, NIH, DHHS, Bethesda, MD, USA; 5Washington Univ., St. Louis, MO, USA; and 6Univ. of Rochester, NY, USA
615A Comparison of the Pharmacokinetics of Ritonavir Boosted Generic (Inhibisam) versus Brand Indinavir
C Zala*1, C S Alexander2, C Ochoa 1, S Guillemi2, L S Ting2, J J Asselin2, P Cahn1, and J S G Montaner2
1Fndn. Huesped, Buenos Aires, Argentina and 2British Columbia Ctr. for Excellence in HIV/AIDS, Vancouver, Canada
616
Pharmacokinetics of Reduced-dosed Indinavir/Ritonavir 400/100 mg every 12 hours in HIV-1-infected Thai Patients
M Boyd*1,2, D Burger3, P Mootsikapun4, T Chuenyam1, S Ubolyam1, J Sangkote1, P Bunyaprawit4, M Horsakulchai4, J Lange1,5, D Cooper1,2, P Phanupak1,6, and K Ruxrungtham1,6
1The HIV Netherlands Australia Thailand Res. Collaboration (HIVNAT), Thai Red Cross AIDS Res. Ctr. Bangkok, Thailand; 2Natl. Ctr. in HIV Epidemiology and Clin. Res., Univ. of New South Wales, Sydney, Australia; 3Univ. Med. Ctr. Nijmegen, The Netherlands; 4Srinagarind Hosp., Faculty of Med., Khon Kaen Univ., Thailand; 5Acad. Med. Ctr., Amsterdam, The Netherlands; and 6Chulalongkorn Univ. Faculty of Med., Bangkok, Thailand
617MDR1 Genotype May Influence CD4+ T-cell P-glycoprotein Activity in HIV-1-infected Persons Receiving Protease Inhibitors
T Hulgan*, J Donahue, R Kim, C Sutcliffe, B Lishawa, F Nicotera, R D'Aquila, and D Haas
Vanderbilt Univ., Nashville, TN, USA
618Relationships between P-glycoprotein, CXCR4 Expression and Saquinavir Antiviral Effect in vitro
B Chandler*, A Owen, D Back, and S Khoo
Univ. of Liverpool, UK
619CYP3A5 and MDR1 (P-gp) Polymorphisms in HIV-infected Adults: Associations with Indinavir Concentrations and Antiviral Effects
P L Anderson*1, J Lamba1,2, E Schuetz2, and C V Fletcher1,2
1Univ. of Colorado Hlth. Sci. Ctr., Denver, USA and 2St. Jude Children’s Res. Hosp., Memphis, TN, USA
619bThe Role of Genetic Polymorphisms of the MDR1 Gene in the MaxCmin1 Study
A Owen*1, Z Fox2, L Almond1, U Bak Dragsted3, D Back1, M Youle4, J Lundgren3, S Khoo1, and The MaxCmin1 Steering Comittee
1Liverpool Univ., UK; 2Royal Free and Univ. Coll. Med. Sch., London, UK; 3Hvidovre Univ. Hosp., Hvidovre, Denmark; and 4Royal Free Hosp., London, UK