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Session 86
Poster Abstracts Pharmacology of Protease Inhibitors Tuesday, 1:30 - 3:30 pm Poster Hall |
| 606 | Atazanavir Plasma Levels Associated with Efficacy and Safety in Protease Inhibitor-experienced HIV-infected Patients A Barrios*, A Rendón, P Ríos, L Martín-Carbonero, D González de Requena, O Gallego, L Valer, I Maida, I Jimenez-Nacher, J Gonzalez-Lahoz, and V Soriano Hosp. Carlos III, Madrid, Spain |
| 607 | Atazanavir Enhances Saquinavir Hard Gel Concentrations in a Ritonavir-Boosted Once Daily Regimen. M Boffito*1, M Kurowski2, G Kruse2, A Hill3, M Nelson1, G Moyle1, A Benzie1, C Higgs1, C Fletcher1, I Hitchcock4, B Gazzard1, and A Pozniak1 1Chelsea and Westminster Hosp., London, UK; 2Therapia GmbH, Berlin, Germany; 3Roche, Welwyn, UK; and 4Bristol-Myers Squibb Co., London, UK |
| 608 | Steady State Pharmacokinetics of Saquinavir Hard Gel/Fosamprenavir 1000/700 plus 100 mg and 200 mg of Ritonavir Twice Daily in HIV+ Patients M Boffito*1, L Dickinson2, A Hill3, M Nelson1, G Moyle1, C Higgs1, C Fletcher1, S Mandalia1, D Back2, B Gazzard1, and A Pozniak1 1Chelsea and Westminster Hosp., London, UK; 2Univ. of Liverpool, UK; and 3Roche, Welwyn, UK |
| 609 | Pharmacologic Management of the Drug-Drug Interaction between Lopinavir/Ritonavir and Amprenavir H E Wynn Vezina*1, R C Brundage1, L Bushman2, and C V Fletcher2 1Univ. of Minnesota, Minneapolis, USA and 2Univ. of Colorado Hlth. Sci. Ctr., Denver, USA |
| 610 | Predictive Power of Genotypic Inhibitory Quotient and Lopinavir Plasma Levels in both Efficacy and Lipid Elevations of LPV/r -based Salvage Regimens at 48 Weeks D González de Requena*, T García-Benayas, O Gallego, F Blanco, L Valer, I Jimenez-Nacher, A L Rendón, and V Soriano Hosp. Carlos III, Inst. de Salud Carlos III, Madrid, Spain |
| 611 | Dose Separation Strategies to Overcome the Pharmacokinetic Interaction of a Triple Protease Inhibitor Regimen Containing Fosamprenavir Lopinavir, and Ritonavir A H Corbett*1, L Davidson1, J J Park1, K Patterson1, J J Eron1, L Ngo1, M L Lim2, M Shelton2, M B Wire2, and A D M Kashuba1 1Chapel Hill, NC, USA and 2Res. Triangle Park, NC, USA |
| 612 | The PharmacokineticInteraction between GW433908 and Lopinavir/Ritonavir (APV10011 and APV10012) M B Wire*1, O J Naderer1, A L Masterman2, Y Lou1, and D S Stein1 1GlaxoSmithKline, Research Triangle Park, NC, USA and 2GlaxoSmithKline, Montreal, Quebec, Canada |
| 613 | Relationship between Lopinavir Concentration and Changes in Lipid Levels at 24 Weeks B Best*1, S May1, M Witt2, C Kemper3, R Larsen4, C Diamond5, P Heseltine6, F He1, E Capparelli1, A McCutchan1, R Haubrich1, and the California Collaborative Treatment Group (CCTG) 1Univ. of California, San Diego, USA; 2Harbor-UCLA Med. Ctr., Univ. of California, Los Angeles Sch. of Med., Torrance, CA, USA; 3Santa Clara Valley Med. Ctr., San Jose, CA, USA; 4Univ. of Southern California, Los Angeles, USA; 5Univ. of California, Irvine, USA; and 6Quest Diagnostics, San Juan Capistrano, CA, USA |
| 614 | 3-Way Pharmacokinetic Interaction among Amprenavir, Efavirenz, and a Second Protease Inhibitor G D Morse*1, S Rosenkranz2, M F Para3, E Adams4, K E Yarasheski5, R C Reichman6, and Adult AIDS Clinical Trials Group (AACTG); DAIDS, NIAID, NIH; Bethesda, MD, USA 1State Univ. of New York at Buffalo, USA; 2Harvard Sch. of Publ. Hlth., Boston, MA, USA; 3Ohio State Univ., Columbus USA; 4DAIDS, NIAID, NIH, DHHS, Bethesda, MD, USA; 5Washington Univ., St. Louis, MO, USA; and 6Univ. of Rochester, NY, USA |
| 615 | A Comparison of the Pharmacokinetics of Ritonavir Boosted Generic (Inhibisam) versus Brand Indinavir C Zala*1, C S Alexander2, C Ochoa 1, S Guillemi2, L S Ting2, J J Asselin2, P Cahn1, and J S G Montaner2 1Fndn. Huesped, Buenos Aires, Argentina and 2British Columbia Ctr. for Excellence in HIV/AIDS, Vancouver, Canada |
| 616 | Pharmacokinetics of Reduced-dosed Indinavir/Ritonavir 400/100 mg every 12 hours in HIV-1-infected Thai Patients M Boyd*1,2, D Burger3, P Mootsikapun4, T Chuenyam1, S Ubolyam1, J Sangkote1, P Bunyaprawit4, M Horsakulchai4, J Lange1,5, D Cooper1,2, P Phanupak1,6, and K Ruxrungtham1,6 1The HIV Netherlands Australia Thailand Res. Collaboration (HIVNAT), Thai Red Cross AIDS Res. Ctr. Bangkok, Thailand; 2Natl. Ctr. in HIV Epidemiology and Clin. Res., Univ. of New South Wales, Sydney, Australia; 3Univ. Med. Ctr. Nijmegen, The Netherlands; 4Srinagarind Hosp., Faculty of Med., Khon Kaen Univ., Thailand; 5Acad. Med. Ctr., Amsterdam, The Netherlands; and 6Chulalongkorn Univ. Faculty of Med., Bangkok, Thailand |
| 617 | MDR1 Genotype May Influence CD4+ T-cell P-glycoprotein Activity in HIV-1-infected Persons Receiving Protease Inhibitors T Hulgan*, J Donahue, R Kim, C Sutcliffe, B Lishawa, F Nicotera, R D'Aquila, and D Haas Vanderbilt Univ., Nashville, TN, USA |
| 618 | Relationships between P-glycoprotein, CXCR4 Expression and Saquinavir Antiviral Effect in vitro B Chandler*, A Owen, D Back, and S Khoo Univ. of Liverpool, UK |
| 619 | CYP3A5 and MDR1 (P-gp) Polymorphisms in HIV-infected Adults: Associations with Indinavir Concentrations and Antiviral Effects P L Anderson*1, J Lamba1,2, E Schuetz2, and C V Fletcher1,2 1Univ. of Colorado Hlth. Sci. Ctr., Denver, USA and 2St. Jude Children’s Res. Hosp., Memphis, TN, USA |
| 619b | The Role of Genetic Polymorphisms of the MDR1 Gene in the MaxCmin1 Study A Owen*1, Z Fox2, L Almond1, U Bak Dragsted3, D Back1, M Youle4, J Lundgren3, S Khoo1, and The MaxCmin1 Steering Comittee 1Liverpool Univ., UK; 2Royal Free and Univ. Coll. Med. Sch., London, UK; 3Hvidovre Univ. Hosp., Hvidovre, Denmark; and 4Royal Free Hosp., London, UK |
