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Session 87   Poster Abstracts
Activity of Drugs against Resistant Viruses
Tuesday, 1:30 - 3:30 pm
Poster Hall
620Phenotypic and Genotypic Profiling of TMC114, a Potent Next-generation PI, against Some 1600 Recent PI-resistant Clinical Isolates
S De Meyer*, H Van Marck, T Van Den Bulcke, J Vingerhoets, H Azijn, R Pauwels, and M-P de Béthune
Tibotec, Mechelen, Belgium
621Antiviral Activity of TMC125 against a Panel of Site-directed Mutants Encompassing Mutations Observed in vitro and in vivo
J Vingerhoets*1, I De Baere1, H Azijn1, T Van den Bulcke1, P McKenna2, T Pattery2, R Pauwels1, and M-P de Béthune1
1Tibotec, Mechelen, Belgium and 2Virco, Mechelen, Belgium
622Synergistic Activity of Lopinavir and Saquinavir on Protease Inhibitor-resistant HIV-1
E Dam1, S Rochas1, J L Faudon1, A Cheret1, L Essioux1, A Hill2, and F Clavel*3
1Viralliance, Paris, France; 2Roche, Welwyn, UK; and 3Inserm U552, Paris, France
623A Short-duration, Single-dug Interruption Determines the Activity of Individual Drugs in Patients on Failing Antiretroviral Therapy
F Maldarelli*1, S Palmer1, M Kearney1, A Wiegand1, D Rock2, J Falloon3, R T Davey3, A Powers2, S Vogel2, A Pau3, R Dewar4, J A Metcalf3, J Mellors5, and J Coffin1
1HIV Drug Resistance Prgm., NCI, NIH, DHHS, Frederick, MD, USA; 2NIAID/CCMD Clin., NIH, DHHS, Bethesda, MD, USA; 3Lab. of Immunoregulation, NIAID, NIH, DHHS, Bethesda, MD, USA; 4SAIC, Frederick, MD, USA; and 5Univ. of Pittsburgh, PA, USA