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Session 98   Poster Abstracts
Drug Resistance Testing: New Methods, Interpretations, and Reproducibility
Monday, 1:30 - 3:30 pm
Poster Hall
695Single-genome Sequencing Is More Sensitive than Standard Genotype Analysis for Detection of HIV-1 Drug-resistance Mutations
M Kearney*1, S Palmer1, F Maldarelli1, C Bixby2, H Bazmi2, D Rock3, J Falloon4, R Davey4, R Dewar3, J Metcalf3, J Mellors2, and J Coffin1
1HIV Drug Resistance Prgm., NCI, NIH, DHHS, Frederick, MD, USA; 2Univ. of Pittsburgh, PA, USA; 3NIAID/CCMD Clin., NIH, DHHS, Bethesda, MD, USA; and 4Lab. of Immunoregulation, NIAID, NIH, DHHS, Bethesda, MD, USA
696A Novel Single-cell Level Phenotypic Assay for Residual Drug Susceptibility and Reduced Replication Capacity of Drug-resistant HIV-1
H Zhang*1, Y Zhou1, C Alcock1, T Kiefer1, D Monie1, J Siliciano1, Q Li2, P Pham1, J Cofrancesco1, D Persaud1, and R Siliciano1,3
1Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA; 2Univ. of Maryland Sch. of Pharmacy, Baltimore, USA; and 3Howard Hughes Med. Inst., Baltimore, MD, USA
697
Accuracy of Neural Network Models in Predicting HIV Treatment Response from Genotype May Depend More on Diversity than Size of Data Sets
B Larder*1, D Wang1, A Revell2, R Harrigan3, J Montaner3, and C Lane4
1The HIV Resistance Response Database Initiative (RDI), Cambridge, UK; 2RDI Ltd., London, UK; 3British Columbia Ctr. for Excellence in HIV/AIDS Vancouver, Canada; and 4NIAID, NIH, DHHS, Bethesda, MD, USA
698Predicting HIV Drug Resistance Using Supervised Machine Learning Methods
J Ravela*, A Ben-Hur, and R W Shafer
Stanford Univ., CA, USA
699Performance of the Celera Diagnostics ViroSeq HIV-1 Genotyping System v2.0 for Sequence-based Analysis of Diverse HIV-1 Strains
S H Eshleman*1, J Hackett Jr2, S P Cunningham1, B Drews3, P Swanson2, C Brennan2, S G Devare2, L Zekeng4, L Kaptue5, and N Marlowe3
1Johns Hopkins Med. Inst., Baltimore, MD, USA; 2Abbott Labs., Abbott Park, IL, USA; 3Celera Diagnostics, Alameda, CA, USA; 4Lab. de Santé Hygiène Mobile, Yaoundé, Cameroon; and 5Univ. of Yaoundé, Cameroon
700A Multi-center Evaluation of Intra-laboratory Reproducibility of HIV-1 Genotyping
D Brambilla*1, D Huang2, S Granger1, C Jennings2, and J Bremer2
1New England Res. Inst., Watertown, MA, USA and 2Rush Univ. Med. Coll., Chicago, IL, USA