Session 7 - 12th CROI

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Session 7 Oral Abstracts
Neuropathogenesis: Molecular Markers and Therapeutic Advances
Wednesday, 10 am - 12:30 pm
302-304

Moderators:

  Roger Pomerantz
  Thomas Jefferson Univ, Philadelphia, PA, USA

  Valerie Wojna
  Univ of Puerto Rico Sch of Med, San Juan

10:00 am 9	HAART Improves Neurocognitive Impairment in HIV+ Individuals in Uganda Ned Sacktor*¹, N Nakasujja², M Wong³, R Skolasky¹, K Robertson⁴, S Musisi², E Katabira², and A Ronald⁵ ¹Johns Hopkins Univ, Baltimore, MD, USA; ²Makerere Univ, Kampala, Uganda; ³Univ of Calgary, Alberta, Canada; ⁴Univ of North Carolina at Chapel Hill, USA; and ⁵Univ of Manitoba, Winnipeg, Canada
10:15 am 10	Chemokine and Cytokine Profiling by Protein Array Technology Shows the Basal Ganglia as the Most Affected Area in HIV Dementia Diana Vargas*¹, C Nascimbene¹, A Lee¹, J Williams², J McArthur¹, C Pardo¹, and Department of Neurology, HIV Neuroscience group ¹Johns Hopkins Univ, Baltimore, MD, USA and ²Bloomberg Sch of Publ Hlth, John Hopkins Univ, Baltimore, MD, USA
10:30 am 11	A High Frequency of HIV Envelopes with Reduced CD4 and CCR5 Dependence in Brain Compared with Lymphoid Tissues of AIDS Patients Elaine Thomas*^1,2, R Dunfee^1,2, D Bogdan³, J Stanton³, K Kunstman³, S Wolinsky³, and D Gabuzda^1,2 ¹Dana-Farber Cancer Inst, Boston, MA, USA; ²Harvard Med Sch, Boston, MA, USA; and ³Northwestern Univ, Feinberg Sch of Med, Chicago, IL, USA
10:45 am 12	Compartmentalized HIV-1 Variants Present in Cerebrospinal Fluid of Asymptomatic Subjects Are Produced by Short-lived Cells Patrick R Harrington*¹, D Haas², and R Swanstrom³ ¹Lineberger Cancer Ctr, Univ of North Carolina at Chapel Hill, USA; ²Vanderbilt Meharry Ctr for AIDS Res, Vanderbilt Univ Med Sch, Nashville, TN, USA; and ³Lineberger Cancer Ctr, Univ of North Carolina at Chapel Hill, USA
11:00 am 13	Experimental Denervation of the Epidermis Demonstrated Reduced Regeration of Ociceptice Fibers in People with HIV Michael Polydefkis*, A Brown, P Hauer, J Griffin, and J McArthur Johns Hopkins Univ, Baltimore, MD, USA
11:15 am 14	Enhancement of HIV-specific Immune Response in an Animal Model for HIV-1 Encephalitis following Pharmacologic Inhibition of Indoleamine 2,3-dioxygenase Raghava Potula*¹, L Poluektova¹, B Knipe¹, J Chrastil¹, D Heilman¹, H Dou¹, H Gendelman¹, D Munn², and Y Persidisky¹ ¹Univ of Nebraska Med Ctr, Omaha, USA and ²Med Coll of Georgia, Augusta
11:30 am 15	Phylogenetic and Sequence Analysis of gp160 from Long-term Progressing Macaques Demonstrates Compartmentalization in Distinct Central Nervous System Sites and Tissue-specific Evolution Maria Chen*¹, E Ryzhova¹, S Westmoreland², A Lackner³, and F González-Scarano¹ ¹Univ of Pennsylvania, Philadelphia, USA; ²Harvard Med Sch, Boston, MA, USA; and ³Tulane Natl Primate Res Ctr, Tulane Univ, Covington, LA, USA
11:45 am 16LB	Signs of Neuronal Damage after Antiretroviral Treatment Interruption in HIV-1 Magnus Gisslén*¹, L Rosengren¹, L Hagberg¹, and R Price² ¹Göteborg Univ, Sahlgrenska Univ Hospital, Göteborg, Sweden and ²San Francisco Gen Hosp, Univ of California, USA
12:00 pm 17	Impact of HAART on NeuroAIDS Ron Ellis Univ of California, San Diego, USA