Session 9 - 12th CROI

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Session 9 Oral Abstracts
Cellular and Viral Factors in Virus-Host Interplay
Wednesday, 10 am - 12:30 pm
Ballroom B/C

10:00 am 28	Structural Studies of an Unliganded Simian Immunodeficiency Virus Gp120 Core Bing Chen*², E Vogan^1,2, H Gong², J Skehel³, D Wiley^1,2, and S Harrison^1,2 ¹Howard Hughes Med Inst, Boston, MA, USA; ²Children's Hosp, Harvard Med Sch, Boston, MA, USA ; and ³Natl Inst of Med Res, London, UK
10:15 am 29	HIV-1 Vpr Helps to Protect the Viral Genome against APOBEC3-mediated Innate Immunity Bärbel Schröfelbauer*, Q Yu, and N Landau Salk Inst for Biological Studies, San Diego, CA, USA
10:30 am 30	A New Mechanism of Antiviral Defense by APOBEC3G Ya-Lin Chiu*, V Soros, K Stopak, J Kreisberg, W Yonemoto, J Neidleman, and W Greene Gladstone Inst of Virology and Immunology, Univ of California, San Francisco, USA
10:45 am 31	Phosphorylation of a Novel SOCS-box Regulates Assembly of the HIV-1 Vif-Cul5 Complex that Promotes APOBEC3G Degradation Andrew Mehle*¹, J Goncalves², M Santa-Marta², M McPike¹, and D Gabuzda¹ ¹Dana-Farber Cancer Inst, Boston, MA, USA and ²Univ of Lisbon, Portugal
11:00 am 32	Selective Assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 Ubiquitin Ligase Complex through a Novel SOCS Box and Upstream Cysteines Zuoxiang Xiao*, Y Yu, E Ehrlich, and X F Yu Johns Hopkins Univ, Baltimore, MD, USA
11:15 pm 33LB	APOBEC3G Hypermutation and Ty1 Restriction in Yeast A Schumacher¹, D Nissley², and Reuben S. Harris*¹ ¹Univ of Minnesota, Minneapolis, USA and ²SAIC-NCI, Frederick, MD, USA
11:30 am 34	Species-specific Variation in the B30.2(SPRY) Domain of TRIM5a Determines the Potency of HIV-1 Restriction Matthew Stremlau*, M Perron, B Song, S Welikala, and J Sodroski Dana-Farber Cancer Inst, Boston, MA, USA
11:45 am 35	Host Factors Affecting the Integration of HIV-1 in Non-dividing cells Jean-Marc Jacqué* and M Stevenson Univ of Massachusetts Med Sch, Worcester, USA
12:00 pm 36	HIV Gag Trafficking and Assembly Are Regulated by the Nuclear History of the Genomic RNA Chad Swanson*, M Ahmad, and M Malim King's Coll London, UK
12:15 pm 37LB	UnPAKing HIV Replication: Evidence for the Involvement of Group I PAK in HIV Infection Deborah Nguyen*, K Wolff, H Yin, J Caldwell, and K Kuhen Genomics Inst. of the Novartis Res. Fndn., San Diego, CA, USA