Session 10 - 12th CROI

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Session 10 Oral Abstracts
Complications of Antiretroviral Therapy
Wednesday, 10 am - 12:30 pm
Auditorium

10:00 am 38	Mixed Patterns of Changes in Central and Peripheral Fat following Initiation of ART Kathleen Mulligan*¹, R Parker², L Komarow², P Tebas³, S Grinspoon⁴, G Robbins⁴, M Dube⁵, and the ACTG 5005S and 384 Study Teams ¹Univ of California, San Francisco, USA; ²Statistical and Data Analysis Ctr, Harvard Sch of Publ Hlth, Boston, MA, USA; ³Univ of Pennsylvania, Philadelphia, USA; ⁴Harvard Univ, Boston, MA, USA; and ⁵Indiana Univ, Indianapolis, USA
10:15 am 39	Treatment of Hypertriglyceridemia in HIV-infected Patients under HAART, by (n-3)Polyunsaturated Fatty Acids: A Double-blind Randomized Prospective Trial in 122 Patients Pierre De Truchis*¹, M Kirstetter², A Perier³, C Meunier⁴, J Gardette⁴, J C Melchior⁵, and Maxepa-VIH Study Group ¹Hosp R Poincare, Univ Paris-IFO,Garches, France; ²Private Practice, Paris, France; ³Cardinal System, Paris, France; ⁴Lab Pierre Fabre Santé, Castres, France; and ⁵Hosp R Poincare, Univ Paris-IFO,Garches, France
10:30 am 40	Switch to a Protease Inhibitor-containing/Nucleoside Reverse Transcriptase Inhibitor-sparing Regimen Increases Appendicular Fat and Serum Lipid Levels without Affecting Glucose Metabolism or Bone Mineral Density. The Results of a Prospective Randomized Trial, ACTG 5125s Pablo Tebas*¹, J Zhang², K Yarasheski³, S Evans², M Fischl⁴, A Shevitz⁵, J Feinberg⁶, A Collier⁷, C Shikuma⁸, B Brizz⁹, F Sattler¹⁰, and Adult AIDS Clinical Trials Group (AACTG) ¹Univ of Pennsylvania, Philadelphia, USA; ²Harvard Sch of Publ Hlth, Boston, MA, USA; ³Washington Univ, St Louis, MO, USA; ⁴Univ of Miami, FL, USA; ⁵Tufts Univ. School of Medicine, Boston, MA, USA; ⁶Univ of Cincinnati Med Ctr, OH, USA; ⁷Univ of Washington, Seattle, USA; ⁸Univ of Hawaii, Honolulu, USA; ⁹Social & Sci Systems, Inc, Silver Spring, MD, USA; and ¹⁰Univ of Southern California, Los Angeles, USA
10:45 am 41	The Effect of Rosiglitazone on PPARg Expression in Human Adipose Tissue Is Limited by Continued Exposure to Thymidine NRTI Patrick Mallon*^1,2, R Sedwell¹, G Rogers³, D Nolan⁴, P Unemori¹, H Wand¹, K Samaras⁵, A Kelleher^1,2, S Emery¹, D Cooper^1,2, A Carr², and The Rosey Investigators ¹Natl Ctr in HIV Epidemiology and Clin Res, Univ of New South Wales, Sydney, Australia; ²St Vincent's Hosp, Sydney, Australia; ³Univ of Adelaide, Australia; ⁴Royal Perth Hosp, Australia; and ⁵Garvan Inst of Med Res, Sydney, Australia
11:00 am 42	Relationship between Prolonged Exposure to Combination ART and Myocardial Infarction: Effect of Sex, Age, and Lipid Changes Wafaa El-Sadr*¹, P Reiss², S De Wit³, A D'Arminio Monforte⁴, R Thiébaut⁵, L Morfeldt⁶, R Weber⁷, C Pradier⁸, G Calvo⁹, M Law¹⁰, O Kirk¹¹, C Sabin¹², N Friis-Møller¹³, J Lundgren¹³, and On behalf of the D:A:D Study Group ¹Community Prgms for Clin Res on AIDS, Harlem Hosp, Columbia Univ, New York, NY, USA ; ²HIV Monitoring Fndn, Academic Med Ctr, Univ of Amsterdam, The Netherlands; ³St-Pierre Cohort, Ctr Hosp Univ St-Pierre, Brussels, Belgium; ⁴L Sacco Hosp, Univ of Milan, Italy; ⁵Aquitaine Cohort, Bordeaux Univ Hosp, INSERM U593, France; ⁶HIVUS, Karolinska Hosp, Stockholm, Sweden; ⁷Zurich Univ Hosp, Switzerland; ⁸Ctr Hosp Univ Nice, Hosp de l'Archet, France; ⁹BASS, Autonomous Univ of Barcelona, Spain; ¹⁰Australian HIV Observational Database, Natl Ctr in HIV Epidemiology and Clin Res, Sydney, Australia; ¹¹EuroSIDA, Copenhagen HIV Prgm, Hvidovre Univ Hosp, Denmark; ¹²Royal Free and Univ Coll, London, UK; and ¹³Copenhagen HIV Prgm, Hvidovre Univ Hosp, Denmark
11:15 am 43	A Pilot Study of Mitochondrial Haplogroups and Peripheral Neuropathy during Antiretroviral Therapy: NWCS238, an Analysis of ACTG Study 384 Todd Hulgan*¹, J Canter¹, J Haines¹, M Ritchie¹, A Kallianpur¹, M Summar¹, G Robbins², R Shafer³, D Clifford⁴, D Haas¹, and the ACTG Study 384 Team ¹Vanderbilt Univ, Nashville, TN, USA; ²Massachusetts Gen Hosp, Harvard Med Sch, Boston, USA; ³Stanford Univ, CA, USA; and ⁴Washington Univ, St Louis, MO, USA
11:30 am 44LB	A 48-week, Randomized, Open-label Comparative Study of Tenofovir DF vs Abacavir as Substitutes for a Thymidine Analog in Persons with Lipoatrophy and Sustained Virological Suppression on HAART Graeme Moyle*¹, C Sabin¹, J Cartledge², M Johnson¹, E Wilkins³, D Churchill⁴, P Hay⁵, A Fakoya⁶, M Murphy⁷, G Scullard⁸, C Leen⁹, G Reilly¹⁰, and The Rave Study Group ¹Royal Free Hospital, London; ²UCL Hospital, London; ³Manchester Royal Infirmary, Manchester; ⁴Brighton General Hospital, Brighton; ⁵St George's Hospital, London; ⁶Newham General Hospital, London; ⁷St Bartholomew's Hospital, London; ⁸St Mary's Hospital, London; ⁹Edinburgh Royal Infirmary, Edinburgh; and ¹⁰Gilead Sciences, UK
11:45 am 45LB	Switching to a Thymidine Analog-sparing or a Nucleoside-sparing Regimen Improves Lipoatrophy: 24-Week Results of a Prospective Randomized Clinical Trial, AACTG 5110 Robert Murphy*¹, J Zhang², R Hafner³, A Shevitz⁴, K Tashima⁵, K Yarasheski⁶, J Forand⁴, B Berzins¹, S Owens⁷, S Evans⁸, P Tebas⁹, and AACTG 5110 Study Team ¹Northwestern Univ, Chicago, IL, USA; ²Harvard Sch of Publ Hlth, Boston, MA, USA; ³NIAID, Bethesda, MD, USA; ⁴Tufts Univ Sch of Med, Boston, MA, USA; ⁵Brown Univ, Providence, RI, USA; ⁶Washington Univ, St Louis, MO, USA; ⁷Frontier Sci Technology Res Fndn, Amherst, NY, USA; ⁸Harvard Sch of Publ Hlth, Boston, MA, USA; and ⁹Univ of Pennsylvania, Philadelphia, USA