Session 23 - 12th CROI

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Session 23 Oral Abstracts
Determinants Driving Humoral and Cellular Immunity in Monkeys and Humans
Thursday, 10 am - 12:30 pm
Ballroom B/C

10:00 am 87	Antigenic Conservation and Immunogenicity of the Co-receptor Binding Site in HIV-1 Subtypes A, B, C, D, F, G, H, and CRF02 Julie Decker*¹, F Bibollet-Ruche¹, X Wei¹, S Wang¹, D Levy¹, C Derdeyn², S Allen², E Hunter², J Hoxie³, E Delaporte⁴, M Peeters⁴, B Hahn¹, P Kwong⁵, J Robinson⁶, and G Shaw¹ ¹Howard Hughes Med Inst, Univ of Alabama at Birmingham, USA; ²Emory Univ, Atlanta, GA, USA ; ³Univ of Pennsylvania, Philadelphia, USA; ⁴Univ of Montpellier, France; ⁵NIAID, Bethesda, MD, USA; and ⁶Tulane Univ, New Orleans, LA, USA
10:15 am 88	Defective Memory B-cell Responses in HIV-infected Patients Susan Moir*¹, A Malaspina¹, S Orsega¹, J Vasquez¹, N Miller¹, E Donoghue¹, S Kottilil¹, M Gezmu¹, D Follman¹, G Vodeiko², R Levandowski², J Mican¹, T W Chun¹, and A Fauci¹ ¹NIAID, Bethesda, MD, USA and ²FDA, Rockville, MD, USA
10:30 am 89	Infectivity and Neutralization of Simian Immunodeficiency Virus with FLAG Epitope Tag Insertion in the gp120 Variable Loops Melissa E Laird* and R Desrosiers New England Primate Res Ctr, Harvard Med Sch, Southborough, MA, USA
10:45 am 90	Control of HIV Replication in Long-term Non-progressors and Patients Partially Controlling Drug-resistant HIV Is Associated with High Levels of HIV-specific IL-2-producing CD4+ T Cells and Low Levels of Immune Activation B Emu¹, E Sinclair¹, D Favre¹, W Moretto¹, R Hoh², J Martin², D Nixon¹, J McCune¹, and Steven Deeks*³ ¹Gladstone Inst of Virology and Immunology, Univ of California, San Francisco, USA; ²Univ of California, San Francisco, USA; and ³Univ of California & San Francisco Dept of Publ Hlth, USA
11:00 am 91	The Majority of Currently Circulating HIV-1 Clade B Viruses Fail to Prime CTL Responses against an Otherwise Immunodominant HLA-A2-restricted Epitope Marcus Altfeld*¹, T Allen¹, E Kalife¹, N Frahm¹, M Addo¹, B Mothe², L Reyor¹, X Yu¹, G Alter¹, M Lichterfeld¹, A Sette³, E Rosenberg¹, P Goulder¹, C Brander¹, and B Walker¹ ¹Massachusetts Gen Hosp, Boston, USA; ²California State Univ, San Marcos, USA; and ³La Jolla Inst of Allergy and Immunology, San Diego, CA, USA
11:15 am 92	Transmission and Accumulation of CTL Escape Variants Explains Apparent Negative Selection in HIV Alasdair Leslie*¹, D Kavanagh², I Honeyborne¹, K Pfafferott¹, C Edwards¹, T Pillay¹, L Hilton¹, C Thobakgale³, D Ramduth³, R Phillips¹, P Klenerrman¹, B Korber⁴, P Kiepiela³, B Walker², and P Goulder¹ ¹Univ of Oxford, UK; ²Partners AIDS Res Ctr, Massachusetts Gen Hosp, Boston, USA; ³Doris Duke Med Res Inst, Durban, South Africa; and ⁴Los Alamos Natl Lab, NM, USA
11:30 am 93	Repertoire, Diversity, and Differentiation of CD8+ CMV-specific T Cells Determine Immune Correlates of Protection against CMV after Recovery from Acute CMV Events in HIV-infected Patients Karim Sacre*¹, G Carcelain¹, N Cassoux¹, A M Fillet¹, D Olive², D Vittecoq¹, C Katlama¹, B Autran¹, and The RESTIMOP and ALT study groups ¹Hosp Pitie-Salpetriere, Paris, France and ²Marseille, France
11:45 am 94LB	Delay of HIV-1 Rebound after Cessation of ART through Passive Administration of Human Neutralizing Antibodies Alexandra Trkola*¹, H Kuster¹, P Rusert¹, B Joos¹, M Fischer¹, C Leemann¹, A Manrique¹, M Huber¹, A Oxenius², R Weber¹, G Stiegler³, B Vcelar³, H Katinger³, L Aceto¹, and H Günthard¹ ¹Zurich Univ Hosp, Switzerland; ²ETH Zurich, Switzerland; and ³Polymun Scientific, Vienna, Austria
12:00 pm 95	Immune Correlates in SIV L Yant, J Loffredo, T Friedrich, S Martin, D O'Connor, and David I Watkins* Wisconsin Natl Primate Res Ctr, Univ of Wisconsin, Madison, USA