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Session 25  Poster Discussion
Poster Discussion: The Role of LEDGF in Viral Replication
Thursday, 2:30 - 3:30 pm
311

Discussants:
  Alan Engelman
  Dana-Farber Cancer Inst, Boston, MA, USA

  Josephine Sire
  INSERM, Marseille, France
      220 LEDGF/p75 Is a Co-factor of Lentiviral Integrases and Plays a Role in HIV Replication
Linos Vandekerckhove*1, F Christ1, K Busschots1, J Vercammen2, S Emiliani3, R Benarous3, M Witvrouw1, Y Engelborgs2, and Z Debyser1
1Rega Inst for Med Res, Katholieke Univ, Leuven, Belgium; 2Katholieke Univ, Leuven, Belgium; and 3Inst Cochin, Inst Natl Sante and Res Med, Ctr Natl Res Sci, Paris, France
      221 LEDGF/p75 Prevents Proteasomal Degradation of HIV-1 Integrase
Manuel Llano*, S Delgado, M Vanegas, and E Poeschla
Mayo Clin Coll of Med, Rochester, MN, USA
      222 Identification of the LEDGF/p75 HIV-1 Integrase-interaction Domain and NLS Reveals NLS-independent Chromatin Tethering
Maria Vanegas*, M Llano, S Delgado, D Thompson, M Peretz, and E Poeschla
Mayo Clin Coll of Med, Rochester, MN, USA
      223 RNA Interference as a Validation Tool for LEDGF/p75 and Other Potential Co-factors for HIV-1 Replication
Frauke Christ*, L Vandekerckhove, M Witvrouw, and Z Debyser
Rega Inst for Med Res, Katholieke Univ, Leuven, Belgium
      224 Neither Importin 7 nor LEDGFp75 Controls HIV RT-Complex Nuclear Import in Macrophages
Steven Zielske* and M Stevenson
Univ of Massachusetts Med Sch, Worcester, USA
      225 Genes Remain Favored Sites for HIV-1 Integration in Cells Reduced for Integrase-binding Proteins p75/LEDGF and HRP-2
Nicholas Vandegraaff*, E Devroe, P Silver, and A Engelman
Dana-Farber Cancer Inst, Boston, MA, USA
      226 Structure Analysis of the Integrase-binding Domain in LEDGF/p75
Peter Cherepanov*1,3, Z Y Sun2, G Wagner2, and A Engelman1,3
1Dana-Farber Cancer Inst, Boston, MA, USA; 2Harvard Med Sch, Boston, MA, USA; and 3Harvard Med Sch, Boston, MA, USA
      227 LEDGF/p75 Is Involved in Targeting of HIV-1 Integrase to Chromosomes, Integration, and Viral Replication
Richard Benarous*1, B Van Maele2, A Mousnier3, M Maroun1, L Vandekerckhove2, K Busschots2, M Witvrouw2, J C Rain4, C Dargemont5, Z Debyser2, and S Emiliani1
1Inst Cochin, Inst Natl Sante and Res Med, Ctr Natl Res Sci, Paris, France; 2Rega Inst for Med Res, Katholieke Univ, Leuven, Belgium; 3Inst Jacques Monod, CNRS, Paris, France; 4Hybrigenics SA, Paris, France; and 5Inst Jacques Monod, CNRS, Paris, France