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Session 27  Poster Discussion
Poster Discussion: Interactions among RTI Resistance Mutations
Thursday, 2:30 - 3:30 pm
302-304

Discussants:
  Lisa Demeter
  Univ of Rochester Med Ctr, NY, USA
      698 The L74V Mutation in HIV-1 RT Diminishes Synthesis of Viral DNA in Real-time PCR and Impairs Rescue of ZDV-terminated DNA Synthesis
Fernando Frankel*, D Turner, B Brenner, Y Quan, and M Wainberg
McGill Univ AIDS Ctr, Lady Davis Inst, Jewish Gen Hosp, Montreal, Canada
      699 Differential Effects of L74V and M184V Mutations on ATP-mediated Primer Unblocking in HIV-1 Reverse Transcriptase Carrying Thymidine Analog Resistance Mutations
Luis R Miranda*1 and M Götte2
1Brigham & Women's Hosp, Harvard Med Sch, Boston, MA, USA and 2McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, Canada
      700 L74V Compensates for the Fitness Defect of K103N+L100I
Christine E Koval* and L Demeter
Univ of Rochester Sch of Med and Dentistry, NY, USA
      701 Evidence by Cloning Analysis of the Rare Coexistence of the K65R/L74V Mutant in the Same HIV Genome
P Colson1, M Henry1, C Tourres1, I Ravaux2, I Poizot-Martin3, and Catherine Tamalet*1
1Timone Hospital, Marseille, France; 2Conception Hosp, Marseille, France; and 3Hosp St-Marguerite, Marseille, France
      702 Clonal Analysis of HIV Quasi-species in Patients Harboring Plasma Genotype with K65R Mutation Associated with Thymidine Analogue Mutations or L74V Substitution
Marc Wirden*1, I Malet1, A Derrache1, A G Marcelin1, B Roquebert1, A Simon1, M Kirstetter1, L Morand-Joubert2, and V Calvez1
1Hosp Pitie-Salpetriere, Paris, France and 2Hosp St-Antoine, Paris, France
      703 Effect of L74V or M184V, with Multiple Thymidine Analogue-associated Mutations, on Reverse Transcriptase Inhibitor Phenotypic Sensitivity
Vinod Trivedi*1, X Han1, M Montes-Walters1, M Filizzola2, M Ferguson1, and W O'Brien1
1Univ of Texas Med Branch, Galveston, USA and 2La Casa Family Hlth Ctr at New Mexico, Santa Fe, USA
      704 Contribution of Non-Thymidine Analog Nucleoside RT Inhibitor Associated Mutations to Phenotypic Hypersusceptibility to Efavirenz
E Coakley and Neil Parkin*
ViroLogic, Inc, South San Francisco, CA, USA