Session 51 - 12th CROI

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Session 51 Poster Abstracts
The Role of LEDGF in Viral Replication
Wednesday, 1:30 - 3:30 pm
Hall D

220	LEDGF/p75 Is a Co-factor of Lentiviral Integrases and Plays a Role in HIV Replication Linos Vandekerckhove*¹, F Christ¹, K Busschots¹, J Vercammen², S Emiliani³, R Benarous³, M Witvrouw¹, Y Engelborgs², and Z Debyser¹ ¹Rega Inst for Med Res, Katholieke Univ, Leuven, Belgium; ²Katholieke Univ, Leuven, Belgium; and ³Inst Cochin, Inst Natl Sante and Res Med, Ctr Natl Res Sci, Paris, France
221	LEDGF/p75 Prevents Proteasomal Degradation of HIV-1 Integrase Manuel Llano*, S Delgado, M Vanegas, and E Poeschla Mayo Clin Coll of Med, Rochester, MN, USA
222	Identification of the LEDGF/p75 HIV-1 Integrase-interaction Domain and NLS Reveals NLS-independent Chromatin Tethering Maria Vanegas*, M Llano, S Delgado, D Thompson, M Peretz, and E Poeschla Mayo Clin Coll of Med, Rochester, MN, USA
223	RNA Interference as a Validation Tool for LEDGF/p75 and Other Potential Co-factors for HIV-1 Replication Frauke Christ*, L Vandekerckhove, M Witvrouw, and Z Debyser Rega Inst for Med Res, Katholieke Univ, Leuven, Belgium
224	Neither Importin 7 nor LEDGFp75 Controls HIV RT-Complex Nuclear Import in Macrophages Steven Zielske* and M Stevenson Univ of Massachusetts Med Sch, Worcester, USA
225	Genes Remain Favored Sites for HIV-1 Integration in Cells Reduced for Integrase-binding Proteins p75/LEDGF and HRP-2 Nicholas Vandegraaff*, E Devroe, P Silver, and A Engelman Dana-Farber Cancer Inst, Boston, MA, USA
226	Structure Analysis of the Integrase-binding Domain in LEDGF/p75 Peter Cherepanov*^1,3, Z Y Sun², G Wagner², and A Engelman^1,3 ¹Dana-Farber Cancer Inst, Boston, MA, USA; ²Harvard Med Sch, Boston, MA, USA; and ³Harvard Med Sch, Boston, MA, USA
227	LEDGF/p75 Is Involved in Targeting of HIV-1 Integrase to Chromosomes, Integration, and Viral Replication Richard Benarous*¹, B Van Maele², A Mousnier³, M Maroun¹, L Vandekerckhove², K Busschots², M Witvrouw², J C Rain⁴, C Dargemont⁵, Z Debyser², and S Emiliani¹ ¹Inst Cochin, Inst Natl Sante and Res Med, Ctr Natl Res Sci, Paris, France; ²Rega Inst for Med Res, Katholieke Univ, Leuven, Belgium; ³Inst Jacques Monod, CNRS, Paris, France; ⁴Hybrigenics SA, Paris, France; and ⁵Inst Jacques Monod, CNRS, Paris, France