Session 67 - 12th CROI

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Session 67 Poster Abstracts
Pathogenesis: Determinants and Viral Factors
Thursday, 1:30 - 3:30 pm
Hall D

340	Mechanism for the Emergence of Less Pathogenic HIV-1 Strains during HAART Nitin Saksena*¹, Y Wang¹, W Dyer², J Sullivan², and C Workman³ ¹Westmead Millennium Inst, Westmead Hosp, Univ of, Sydney, Australia; ²Australian Red Cross, Sydney; and ³Ground Zero Med Ctr, Darlinghurst, Australia
341	Unique Contribution of V5-gp41to HIV-1 Envelope-mediated Cytopathicity in the Thymus Eric Meissner*, N Coffield, and L Su Univ of North Carolina at Chapel Hill, USA
342	HIV- Envelope Diversity Correlates with in vitro Replication Capacity and Predicts Spontaneous Control of Plasma Viremia after Treatment Interruptions B Joos¹, A Trkola¹, M Fischer¹, H Kuster¹, C Leemann¹, J Böni², A Oxenius³, D Price⁴, R Phillips⁵, J Wong⁶, B Hirschel⁷, R Weber¹, Huldrych Günthard*¹, and A the Swiss HIV Cohort Study⁸ ¹Zurich Univ Hosp, Switzerland; ²Swiss Natl Ctr for Retroviruses, Zürich; ³Swiss Fed Inst of Tech, Zürich; ⁴Vaccine Res Ctr, NIAID, NIH, DHHS, Bethesda, MD, USA; ⁵Oxford Univ, UK; ⁶Univ of California, San Diego, USA; ⁷Geneva Univ Hosp, Switzerland; and ⁸Switzerland
343	Viral Kinetics in Acute SIV/SHIV Infection: Estimation of the 'Basic Reproductive Ratio (R0)' Hiroshi Mohri*¹, R Ribeiro², N Mushtaq¹, R Bohm³, A Gettie¹, A Perelson⁴, and D Ho¹ ¹Aaron Diamond AIDS Res Ctr, Rockefeller Univ, New York, NY, USA; ²Los Alamos Natl Lab, NM, USA; ³Tulane Natl Primate Res Ctr, Tulane Univ, Covington, LA, USA; and ⁴Los Alamos Natl Lab, NM, USA
344	Impaired HIV-1 Replicative Fitness in Atypical Viremic Long-term Non-progressor Individuals Jan Weber*¹, R Assad², J Weberova¹, M Lederman², and M Quinones-Mateu¹ ¹Cleveland Clin Fndn, OH, USA and ²Case Western Reserve Univ, Cleveland, OH, USA
345	HIV-1 Replication Capacity as an Independent Predictor of Pre-treatment CD4 Lymphocyte Count Charles Hicks*¹, J Eron², P Keiser³, J Stout¹, S Napravnik², J Giner¹, P Menezes², C Castellano¹, J Weidler⁴, T Korich⁴, and M Bates⁴ ¹Duke Univ Med Ctr, Durham, NC, USA; ²Univ of North Carolina at Chapel Hill, USA; ³Univ of Texas Southwestern, Dallas, USA; and ⁴ViroLogic, Inc, South San Francisco, CA, USA
346	X4 HIV-1 Induces Apoptosis in Immature Thymocytes S Choudhary*¹, D Powell², R Walker², C Walsh¹, J Anderson⁴, V Planelles⁴, and D Camerini¹ ¹Univ of California, Irvine, USA; ²Millennium Pharma, Cambridge, MA, USA; and ⁴Univ of Utah Sch of Med, Salt Lake City, USA
347	Evolution of Pathogenic HIV-1 Variants within Gut-associated Lymphoid Tissue Marcel Curlin*¹, D Mai¹, J Elliott², P Anton², and J Mullins¹ ¹Univ of Washington, Seattle, USA and ²Univ of California, Los Angeles, USA
348	Cysteine Mutation in HIV-1 nef Associated with Slowed AIDS Disease Progression Martin Tolstrup*, A Laursen, M Duch, F Skou Pedersen, and L Ostergaard Aarhus, Denmark
349	Lack of Temporal Structure for the Short-term Viral Evolution in HIV-1 Asymptomatic Naïve Patients Gonzalo Bello*¹, C Casado², S García³, C Rodríguez³, J del Romero³, and C López-Galíndez² ¹Oswaldo Cruz Inst, Fiocruz, Rio de Janeiro, Brazil; ²Inst de Salud Carlos III, Majadahonda, Spain; and ³Ctr de Salud Sandoval, Comunidad Autónoma de Madrid, Spain
350	Few Mutations in the 5´ Leader Region Mediate Fitness Recovery of Debilitated Human Inmunodeficiency Antonio V Borderia*¹, E Yuste², E Domingo³, and C López-Galíndez¹ ¹Inst de Salud Carlos III, Majadahonda, Madrid, Spain; ²New England Primate Res Ctr, Harvard Med Sch, Southborough, MA, USA; and ³Univ Autónoma de Madrid, Cantoblanco, Spain
351	R5 and X4 Tropic HIV-1 Envelope-mediated Membrane Fusion Is Associated with Disease Stage Wei Huang*¹, S Fransen¹, J Toma¹, T Wrin¹, S Little², D Richman², S Deeks³, J Whitcomb¹, and C Petropoulos¹ ¹ViroLogic, Inc, South San Francisco, CA, USA; ²Univ of California, San Diego, USA; and ³Univ of California, San Francisco, USA
352	Selection and Evolution of V1-V2 Length and Glycosylation of Transmitted HIV-1 Variants Manish Sagar*¹, B Chohan¹, D Lang², X Wu¹, B Korber², L Lavreys³, B Richardson⁴, and J Overbaugh¹ ¹Fred Hutchinson Cancer Res Ctr, Seattle, WA, USA; ²Los Alamos Natl Lab, NM, USA; ³Univ of Washington, Seattle, USA; and ⁴Fred Hutchinson Cancer Res Ctr, Seattle, WA, USA
353	A Pathogenic Simian-human Immunodeficiency Virus That Uses CCR5 as Co-receptor and Encodes HIV Clade C Env Ruijiang Song*^1,5, S Mirshahidi^1,5, A L Chenine^1,5, C McCann^1,5, T Wang^1,5, P L Li^1,5, K Buckley², R Grisson^1,5, J Whitney^1,5, R Rasmussen^1,5, H Ong², C Wood³, H McClure⁴, and R Ruprecht^1,5 ¹Dana-Farber Cancer Inst, Boston, MA, USA; ²Dana-Farber Cancer Inst, Boston, MA, USA; ³Univ of Nebraska, Lincoln, USA; ⁴Yerkes Natl Primate Res Ctr, Emory Univ, Atlanta, GA, USA; and ⁵Harvard Med Sch, Boston, MA, USA