Session 75 - 12th CROI

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Session 75 Poster Abstracts
Neuropathogenesis: Therapy and Clinical Studies
Friday, 1:30 - 3:30 pm
Hall D

397	HIV Neuropathy Natural History Cohort Study: Clinical and Laboratory Features, and Risk Factors for Progression: ACTG A5117 David Simpson*¹, S Evans², D Kitch², J McArthur³, D Asmuth⁴, B Cohen⁵, K Goodkin⁶, C Shikuma⁷, J Weigh⁷, Y So⁸, C Marra⁹, R Diaz-Arrastia¹⁰, L Millar¹¹, S Shriver¹², D Clifford¹³, and ACTG A5117 Study Group ¹Mt Sinai Hosp, New York, NY, USA; ²Harvard Sch of Publ Hlth, Boston, MA, USA; ³Johns Hopkins Univ Sch of Med, Baltimore, MD, USA; ⁴Univ of California, Davis Med Ctr, Sacramento, USA; ⁵Northwestern Univ Med Ctr, Chicago, IL, USA; ⁶Univ of Miami, FL, USA; ⁷Univ of Hawaii Sch of Med, Honolulu, USA; ⁸Stanford Univ Med Ctr, CA, USA; ⁹Univ of Washington Sch of Med, Seattle, USA; ¹⁰Univ of Texas Southwestern Med Branch, Dallas, USA; ¹¹Frontier Sci & Tech Res Fndn, Amherst, NY, USA; ¹²AACTG Operations Office, Silver Spring, MD, USA; and ¹³Washington Univ Sch of Med, St Louis, MO, USA
398	ACTG 5117 HIV-associated Sensory Neuropathy Cohort: Analysis of Epidermal Nerve Fiber Densities L Zhou¹, P Hauer², D Kitch³, Justin McArthur*², M Gerschenson⁴, C Marra⁵, D Clifford⁶, V Valcour⁴, R Diaz-Arrastia⁷, L Millar⁸, S Shriver⁹, B Cohen¹⁰, Y So¹¹, S Evans³, D Simpson¹², and ACTG Neurological complications group ¹Cleveland Clin Fndn, OH, USA; ²Johns Hopkins Univ, Baltimore, MD, USA; ³Harvard Sch of Publ Hlth, Boston, MA, USA; ⁴Univ of Hawaii, Honolulu, USA; ⁵Univ of Washington, Seattle, USA; ⁶Washington Univ, St Louis, MO, USA; ⁷Univ of Texas Southwestern, Dallas, USA; ⁸Frontier Sci & Tech Res Fndn, Amherst, NY, USA; ⁹AACTG Operations Office, Rockville, MD, USA; ¹⁰Northwestern Univ, Chicago, IL, USA; ¹¹Stanford Univ, CA, USA; and ¹²Mt Sinai Sch of Med, New York, NY, USA
399	Peripheral Neuropathy and Oxidant Stress during ART: NWCS230, an Analysis of ACTG Study 384 Todd Hulgan*¹, J Morrow¹, X Sun², M Hughes², L Smeaton², E Terry¹, G Robbins³, R Shafer⁴, D Clifford⁵, G McComsey⁶, J Canter¹, D Haas¹, and the ACTG Study 384 Team ¹Vanderbilt Univ, Nashville, TN, USA; ²Statistical and Data Analysis Ctr, Harvard Sch of Publ Hlth, Boston, MA, USA; ³Massachusetts Gen Hosp, Harvard Med Sch, Boston, USA; ⁴Stanford Univ, CA, USA; ⁵Washington Univ, St Louis, MO, USA; and ⁶Case Western Reserve Univ, Cleveland, OH, USA
400	Alcohol and Injection Drug Use Does Not Influence Epidermal Nerve Fiber Densities in Subjects Exposed to Dideoxynucleoside Analogs Anita Venkataramana*, R Skolasky, J Creighton, S Raman, and J McArthur Johns Hopkins Univ, Baltimore, MD, USA
401	Long-term Effect of HAART on Intrathecal HIV-1 Replication despite Systemic Viro-Immunological Failure S Palmieri, L Galli, R Pedale, A Bestetti, S Sala, A Lazzarin, and Paola Cinque* San Raffaele Sci Inst, Milan, Italy
402	Enfuvirtide Cerebrospinal Fluid Pharmacokinetics: a Potential Tool to Analyze CSF HIV Origin and the Therapeutic Role of Local Drug Penetration Richard W Price*¹, R Palmatier², S Wring², J Lu^3,4, B Baker², J Sailstad², N Lollo¹, S Spudich¹, R Hoh⁵, T Liegler⁵, D Miralles², D Kuritzkes^3,4, and S Deeks⁵ ¹Univ of California, San Francisco, USA; ²Trimeris, Inc, Durham, NC, USA; ³Brigham & Women's Hosp, Harvard Med Sch, Boston, MA, USA; ⁴Harvard Med Sch, Boston, MA, USA; and ⁵Univ of California, San Francisco, USA
403	Kaletra Independently Reduces HIV Replication in Cerebrospinal Fluid G van den Brande¹, J Marquie-Beck¹, E Capparelli¹, R Ellis¹, A McCutchan¹, A Hermes², M Buzzell¹, and Scott Letendre*¹ ¹Univ of California, San Diego, USA and ²Abbott Labs, Abbott Park, IL, USA
404	Meta-analysis of Cidofovir in AIDS-related Progressive Multifocal Leukoencephalopathy on HAART: Survival and Neurological Outcome Andrea De Luca*¹, P Pezzotti², J Gasnault³, P Cinque⁴, J Berenguer⁵, S Di Giambenedetto¹, A Cingolani¹, Y Taoufik³, R Pedale⁴, P Miralles⁵, D Larussa⁶, S Sinha⁷, C Marra⁷, A Ammassari¹, A Antinori⁶, and for Gesida 9/99, IRINA and AACTG 363 Study Groups ¹Catholic Univ, Rome, Italy; ²Agency for Publ Hlth Lazio Region, Rome, Italy; ³Hosp Bicêtre, Paris, France; ⁴San Raffaele Sci Inst, Milan, Italy; ⁵Hosp Gregorio Marañon, Madrid, Spain; ⁶L Spallanzani, IRCCS, Rome, Italy; and ⁷Univ of Washington, Seattle, USA