Session 77 - 12th CROI

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Session 77 Poster Abstracts
NK Cells in HIV Infection
Thursday, 1:30 - 3:30 pm
Hall D

414	Innate Immunity in HIV Infection: Enhanced Natural Killer Cell-death and Turnover Mediated by Altered Expression of Interferon-stimulated Genes (ISG)s Shyam Kottilil*¹, J Jackson¹, T W Chun¹, M O'Shea¹, M McLaughlin¹, J Yang², R Lempicki², and A Fauci¹ ¹NIAID, Bethesda, MD, USA and ²SAIC-NCI, Frederick, MD, USA
415	Investigation of Natural Killer Cell Function and Phenotype in HIV Long-term Non-progression Geraldine O'Connor*¹, A Holmes², F Mulcahy², and C Gardiner¹ ¹Trinity Coll Dublin, Ireland and ²St James's Hosp, Dublin, Ireland
416	Chronic HIV-1 Infection Leads to a Loss of NK Cells with a Preferential Depletion of CD56^bright NK Cells Galit Alter*, J Malenfant, N Teigen, and M Altfeld Massachusetts Gen Hosp, Boston, USA
417	Low NK Cell Numbers are Associated with Fast Progressive HIV-infection B Castro Frenzel¹, H Heiken¹, U Moebius¹, S Kovalczik¹, S Corey², K Ulbricht¹, M Stoll¹, R Schmidt¹, S Kalams², and Dirk Meyer-Olson*¹ ¹Med Univ Hannover, Germany and ²Vanderbilt Univ Med Ctr, Nashville, TN, USA
418	Disconnect between the Recovery of NK Cell-mediated Cytotoxicity to HIV-infected Targets and Restoration of NK Subsets in ART-suppressed HIV-1-infected Individuals Livio Azzoni*¹, J Chehimi¹, M Farabaugh¹, S Creer¹, K Mounzer², J Kostman³, C Gallo², J Ondercin², J Schull², and L Montaner¹ ¹Wistar Inst, Philadelphia, PA, USA; ²Jonathan Lax Clin, Philadelphia FIGHT, PA, USA; and ³Univ of Pennsylvania, Philadelphia, USA
419	Natural Killer Cell NKG2A Expression is Unaffected by Short Term Increases in HIV-1 Viremia during Treatment Interruption Christopher M Mela*¹, M Goodier¹, C Burton¹, N Imami¹, M Nelson², B Gazzard², and F Gotch¹ ¹Imperial Coll, London, UK and ²Chelsea and Westminster Hosp, London, UK
420	Longitudinal Analysis and Modeling Identifies Changes in Innate Immunity Parameters as Predictive Correlates of CD4 Reconstitution in ART-Treated HIV-1 Infection Livio Azzoni*¹, J Chehimi¹, R June¹, M Farabaugh¹, B Thiel¹, L Zhou², and L Montaner¹ ¹Wistar Inst, Philadelphia, PA, USA and ²Univ of Pennsylvania, Philadelphia, USA
421	Retained NK and DC Subsets upon Viral Replication following Treatment Interruption in Chronically Suppressed HIV-1-infected Subjects Emmanouil Papasavvas*¹, L Azzoni¹, J Chehimi¹, B Thiel¹, M Pistilli¹, M Farabaugh¹, A Mackiewicz¹, S Creer¹, C Gallo², K Mounzer², J Ondercin², J Shull², J Kostman³, and L Montaner¹ ¹Wistar Inst, Philadelphia, PA, USA; ²Philadelphia FIGHT, PA, USA; and ³Philadelphia FIGHT, PA, USA
422	Altered NK Cell Repertoire Is Detected by Real-time PCR and Phenotypic Analysis of Exposed Uninfected Vietnamese Intravascular Drug Users S Ravet¹, D Scott-Algara², E Bonnet¹, H Trang³, L Troung³, N Nguyen⁴, E Vivier⁵, F Barré-Sinoussi², G Pancino², and Pascale Paul*¹ ¹Conception Hosp, Marseille, France; ²Pasteur Inst, Paris, France; ³Inst Pasteur, Ho Chi Minh City, Vietnam; ⁴Hosp Binh Trieu, Ho Chi Minh City, Vietnam; and ⁵Inst Natl Hlth and Res Med, Marseille, France