Session 88 - 12th CROI

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Session 88 Poster Abstracts
Construction and Evaluation of Vaccine Strategies
Wednesday, 1:30 - 3:30 pm
Hall D

484	Electroporation Significantly Enhances Cell-mediated and Humoral Immune Responses to DNA-based HIV-1 Vaccines in Animal Models David Gardiner*^1,2, Y Huang¹, S Basu¹, D Hannaman³, A Luxembourg³, B Ellefsen³, Y Song¹, and D Ho¹ ¹Aaron Diamond AIDS Res Ctr, Rockefeller Univ, New York, NY, USA; ²Weill Med Coll, New York, NY, USA; and ³Ichor Med Systems, Inc, San Diego, CA, USA
485	Design and in vitro characterization of a DNA prime Virus-like Particle Boost HIV-1 Vaccine Targeting the Membrane-proximal Region of gp41 David Gardiner*^1,2, Y Huang², S Basu², Y Song², and D Ho² ¹Weill Med Coll, New York, NY, USA and ²Aaron Diamond AIDS Res Ctr, Rockefeller Univ, New York, NY, USA
486	Enhanced Immunity to HIV-1 Using DNA Prime / Recombinant Env Trimer Boost Joseph F Bower*¹, Y Li², R Wyatt², and T Ross¹ ¹Univ of Pittsburgh Sch of Med, PA, USA and ²Vaccine Res Ctr, NIAID, NIH, DHHS, Bethesda, MD, USA
487	Better Conservation of CD8 T- cell Response than CD4 T- cell Response across Multiple Clades of HIV-1 Raised by a Clade B DNA/MVA HIV-1 Vaccine in Macaques Rama Rao Amara*¹, S Sharma¹, P Nigam¹, and H Robinson¹ ¹Emory Univ, Atlanta, GA, USA
488	Generation of Cross-reactive Neutralizing Antibody against HIV-1 by a DNA/MVA SHIV-89.6 Vaccine Harriet Robinson*¹, D Montefiori², F Villinger¹, and R Amara¹ ¹Emory Univ, Atlanta, GA, USA and ²Duke Univ, Durham, NC, USA
489	Signature for Long-term Vaccine-mediated Control of a SHIV-89.6P Challenge Shanmugalakshmi Sadagopal*¹, R Amara¹, D Montefiori², L Wyatt³, S Staprans¹, H McClure¹, B Moss³, and H Robinson¹ ¹Yerkes Natl Primate Res Ctr, Emory Univ, Atlanta, GA, USA; ²Duke Univ Med Ctr, Durham, NC, USA; and ³NIAID, Bethesda, MD, USA
490	Virus-specific Mucosal and Systemic Immunity Induced by Nasal or Intramuscular DNA-MVA Vaccination and its Effect on SHIV Challenge Ewa Micewicz*¹, S W Wang¹, P Kozlowski¹, D Aurora¹, A Carville², K Mansfield², and A Aldovini¹ ¹Children's Hosp, Harvard Med Sch, Boston, MA, USA and ²New England Primate Res Ctr, Harvard Med Sch, Southborough, MA, USA
491	Functionally Significant Adenovirus Serotype 5 Neutralizing Antibodies Are Directed Primarily Against the Adenovirus Hexon Protein Shawn Sumida*¹, D Truitt¹, A Lemckert², R Vogels², J Custers², M Addo³, S Lockman⁴, T Peter⁴, F Peyerl¹, S Jackson¹, M Essex⁴, B Walker³, J Goudsmit², M Havenga², and D Barouch¹ ¹Beth Israel Deaconess Med Ctr and Harvard Med Sch, Boston, MA, USA; ²Crucell, Leiden, The Netherlands; ³Partners AIDS Res Ctr, Massachusetts Gen Hosp, Harvard Med Sch, Charlestown, USA; and ⁴Harvard Sch of Publ Hlth, Boston, MA, USA
492	A Novel Clostridium perfringens-based SIV Vaccine Induces Maturation of Dendritic Cells and Enables Dendritic Cell Priming of T Cells Ruth Helmus*, Y Chen, T Wehrli, and P Gupta Univ of Pittsburgh, PA, USA