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Session 89
Poster Abstracts
Enhancing Immune Responses to Vaccines
Wednesday, 1:30 - 3:30 pm
Hall D
493
Plasmid Vaccines Containing Engineered IL-12 or IL-15 Drive High Levels of CD8 Antigen-Specific Effector Cells with Different Immunological Profiles
J Boyer
1
, Sandra Calarota*
1
, M Kutzler
1
, E Nietrzeba
1
, S Kumar
1
, R Parkinson
1
, V Roopchand
2
, M Sidhu
2
, M Lewis
3
, P Silvera
4
, G Pavalkis
5
, K Muthumani
1
, T Waldman
5
, and D Weiner
1
1
Univ of Pennsylvania, Philadelphia, USA;
2
Vaccines Discovery, Wyeth, Pearl River, NY, USA;
3
Bioqual, Inc, Rockville, MD, USA;
4
Southern Res Inst, Frederick, MD, USA; and
5
NCI, NIH, DHHS, Bethesda, MD, USA
494
HLA-driven Optimization of an HIV Vaccine Immunogen
V Jojic
1
, D Heckerman
1
, C Kadie
1
, C Meek
1
, C Moore
2
, M John
2
, and S Mallal
2
1
Microsoft Res, Redmond, WA, USA and
2
Royal Perth Hosp, Australia
495
Enhancing Responses to DNA Vaccination Using Plasmids for Soluble, Multimeric CD40 Ligand and Glucocorticoid-induced Tumor Necrosis Factor Receptor Ligand
G Stone
1
, S Barzee
1
, V Snarsky
1
, K Kee
1
, X F Yu
2
, and Richard Kornbluth*
1
1
Univ of California, San Diego, USA and
2
John Hopkins Sch of Hygiene & Publ Hlth, Baltimore, MD, USA
496
Novel Bacteria-derived Glycolipids and Sulfatide Analogs Are Potential HIV Vaccine Adjuvants That Act through Stimulation of CD1d-Restricted natural Killer T Cells
M Poles
1,2
, A Horowitz
1
, D Wu
3
, G W Xing
3
, Y Kinjo
4
, B Sullivan
4
, O Plettenburg
3
, M Kronenberg
4
, C H Wong
3
, D Ho
1
, and Moriya Tsuji*
1,2
1
Aaron Diamond AIDS Res Ctr, Rockefeller Univ, New York, NY, USA;
2
New York Univ Sch of Med, NY, USA;
3
The Scripps Res Inst, La Jolla, CA, USA; and
4
La Jolla Inst of Allergy and Immunology, San Diego, CA, USA